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Details on Person UniProt:P40926 MDH2
| Class:Id | ReferenceGeneProduct:59107 |
|---|---|
| _chainChangeLog | transit peptide:1-24 added on Sat February 7 2015;chain:25-338 added on Sat February 7 2015 |
| _displayName | UniProt:P40926 MDH2 |
| _timestamp | 2025-02-21 19:09:13 |
| chain | transit peptide:1-24 chain:25-338 |
| checksum | AAB9F5E5B2FBC8CA |
| comment | CATALYTIC ACTIVITY (S)-malate + NAD(+) = oxaloacetate + NADH + H(+)ACTIVITY REGULATION Enzyme activity is enhanced by acetylation.SUBUNIT Homodimer.SUBCELLULAR LOCATION Acetylation is enhanced by up to 67% after treatment either with trichostin A (TSA) or with nicotinamide (NAM) with the appearance of tri- and tetraacetylations. Glucose also increases acetylation by about 60%.DISEASE The disease is caused by variants affecting the gene represented in this entry.SIMILARITY Belongs to the LDH/MDH superfamily. MDH type 1 family.ONLINE INFORMATION Malate dehydrogenase entry |
| description | recommendedName: Malate dehydrogenase, mitochondrial ecNumber evidence="9"1.1.1.37 |
| geneName | MDH2 |
| identifier | P40926 |
| isSequenceChanged | FALSE |
| keyword | 3D-structure Acetylation Alternative splicing Disease variant Epilepsy Glycoprotein Mitochondrion NAD Oxidoreductase Phosphoprotein Proteomics identification Reference proteome Transit peptide Tricarboxylic acid cycle |
| modified | [InstanceEdit:9836292] Weiser, Joel, 2023-05-25 [InstanceEdit:9852000] Weiser, Joel, 2023-11-03 [InstanceEdit:9926675] Weiser, Joel, 2024-11-03 [InstanceEdit:9939033] Weiser, Joel, 2025-02-21 |
| name | MDH2 |
| referenceDatabase | [ReferenceDatabase:2] UniProt |
| referenceGene | [ReferenceDNASequence:8957869] ENSEMBL:ENSG00000146701 MDH2 [Homo sapiens] |
| secondaryIdentifier | MDHM_HUMAN A8K414 B2RE78 B4DE44 E9PDB2 O43682 |
| sequenceLength | 338 |
| species | [Species:48887] Homo sapiens |
| (isoformParent) | [ReferenceIsoform:8977096] UniProt:P40926-1 MDH2 [Homo sapiens] [ReferenceIsoform:8977097] UniProt:P40926-2 MDH2 [Homo sapiens] |
| (referenceEntity) | [EntityWithAccessionedSequence:70977] MDH2 [mitochondrial matrix] [Homo sapiens] [EntityWithAccessionedSequence:8958608] MDH2 [extracellular region] [Homo sapiens] |
| (referenceSequence) | [ModifiedResidue:9854237] palmitoylated-L-cysteine at 138 |
| [Change default viewing format] | |
No pathways have been reviewed or authored by UniProt:P40926 MDH2 (59107)
