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Details on Person UniProt:Q9Y5Q3 MAFB
| Class:Id | ReferenceGeneProduct:58939 |
|---|---|
| _chainChangeLog | chain:1-323 added on Fri February 6 2015 |
| _displayName | UniProt:Q9Y5Q3 MAFB |
| _timestamp | 2026-02-20 21:31:44 |
| chain | chain:1-323 |
| checksum | A0F3C09F8936CB16 |
| comment | FUNCTION Acts as a transcriptional activator or repressor (PubMed:27181683). Plays a pivotal role in regulating lineage-specific hematopoiesis by repressing ETS1-mediated transcription of erythroid-specific genes in myeloid cells. Required for monocytic, macrophage, osteoclast, podocyte and islet beta cell differentiation. Involved in renal tubule survival and F4/80 maturation. Activates the insulin and glucagon promoters. Together with PAX6, transactivates weakly the glucagon gene promoter through the G1 element. SUMO modification controls its transcriptional activity and ability to specify macrophage fate. Binds element G1 on the glucagon promoter (By similarity). Involved either as an oncogene or as a tumor suppressor, depending on the cell context. Required for the transcriptional activation of HOXB3 in the rhombomere r5 in the hindbrain (By similarity).SUBUNIT Homodimer or heterodimer with other bHLH-Zip transcription factors. Binds DNA as a homodimer or a heterodimer. Forms homodimers and heterodimers with FOS, FOSB and FOSL2, but not with JUN proteins (JUN, JUNB and JUND). Interacts with PAX6; the interaction is direct. Interacts with ETS1 and LRP1 (By similarity). Interacts with the intracellular cytoplasmic domain of LRP1 (LRPICD); the interaction results in a moderate reduction of MAFB transcriptional potential.SUBCELLULAR LOCATION Ubiquitous.DOMAIN The leucine-zipper domain is involved in the interaction with LRPICD.PTM Phosphorylated by GSK3 and MAPK13 on serine and threonine residues.PTM Sumoylated. Sumoylation on Lys-32 and Lys-297 stimulates its transcriptional repression activity and promotes macrophage differentiation from myeloid progenitors (By similarity).DISEASE The disease is caused by variants affecting the gene represented in this entry.DISEASE The disease is caused by variants affecting the gene represented in this entry.SIMILARITY Belongs to the bZIP family. Maf subfamily. |
| description | recommendedName: Transcription factor MafB shortName: Maf-B alternativeName: V-maf musculoaponeurotic fibrosarcoma oncogene homolog B |
| geneName | MAFB KRML |
| identifier | Q9Y5Q3 |
| isSequenceChanged | FALSE |
| keyword | Activator Disease variant DNA-binding Isopeptide bond Nucleus Proteomics identification Proto-oncogene Reference proteome Repressor Transcription Transcription regulation Tumor suppressor Ubl conjugation |
| modified | [InstanceEdit:9836292] Weiser, Joel, 2023-05-25 [InstanceEdit:9852000] Weiser, Joel, 2023-11-03 [InstanceEdit:9926675] Weiser, Joel, 2024-11-03 [InstanceEdit:9983091] Weiser, Joel, 2026-02-20 |
| name | MAFB |
| referenceDatabase | [ReferenceDatabase:2] UniProt |
| referenceGene | [ReferenceDNASequence:8990824] ENSEMBL:ENSG00000204103 MAFB [Homo sapiens] |
| secondaryIdentifier | MAFB_HUMAN B3KNE1 Q9H1F1 |
| sequenceLength | 323 |
| species | [Species:48887] Homo sapiens |
| (referenceEntity) | [EntityWithAccessionedSequence:3788667] MAFB [nucleoplasm] [Homo sapiens] [EntityWithAccessionedSequence:3788674] monoSUMO1-K32,297-MAFB [nucleoplasm] [Homo sapiens] |
| (referenceSequence) | [GroupModifiedResidue:3788672] sumoylated lysine (monoSUMO1 [nucleoplasm]) at 32 [GroupModifiedResidue:3788676] sumoylated lysine (monoSUMO1 [nucleoplasm]) at 297 |
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No pathways have been reviewed or authored by UniProt:Q9Y5Q3 MAFB (58939)
