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Details on Person UniProt:Q9UPN3-2 MACF1
| Class:Id | ReferenceIsoform:58925 |
|---|---|
| _chainChangeLog | chain:1-7388 added on Fri February 6 2015 |
| _displayName | UniProt:Q9UPN3-2 MACF1 |
| _timestamp | 2026-05-15 21:12:51 |
| chain | chain:1-7388 |
| checksum | B044DC183C048416 |
| comment | FUNCTION F-actin-binding protein which plays a role in cross-linking actin to other cytoskeletal proteins and also binds to microtubules (PubMed:15265687, PubMed:20937854). Plays an important role in ERBB2-dependent stabilization of microtubules at the cell cortex (PubMed:20937854). Acts as a positive regulator of Wnt receptor signaling pathway and is involved in the translocation of AXIN1 and its associated complex (composed of APC, CTNNB1 and GSK3B) from the cytoplasm to the cell membrane (By similarity). Has actin-regulated ATPase activity and is essential for controlling focal adhesions (FAs) assembly and dynamics (By similarity). Interaction with CAMSAP3 at the minus ends of non-centrosomal microtubules tethers microtubules minus-ends to actin filaments, regulating focal adhesion size and cell migration (PubMed:27693509). May play role in delivery of transport vesicles containing GPI-linked proteins from the trans-Golgi network through its interaction with GOLGA4 (PubMed:15265687). Plays a key role in wound healing and epidermal cell migration (By similarity). Required for efficient upward migration of bulge cells in response to wounding and this function is primarily rooted in its ability to coordinate microtubule dynamics and polarize hair follicle stem cells (By similarity). As a regulator of actin and microtubule arrangement and stabilization, it plays an essential role in neurite outgrowth, branching and spine formation during brain development (By similarity).SUBUNIT Isoform 2: Interacts with MAPRE1, CLASP1, CLASP2, AXIN1 and LRP6 (By similarity). Isoform 2: Found in a complex composed of MACF1, APC, AXIN1, CTNNB1 and GSK3B (By similarity). Isoform 2: Interacts with GOLGA4 (PubMed:15265687). Isoform 2: Interacts with CAMSAP3 (PubMed:27693509, PubMed:27802168).INTERACTION The phosphorylated form is found in the cytoplasm while the non-phosphorylated form associates with the microtubules (By similarity). Localizes to the tips of microtubules (PubMed:27693509). Associated with the minus-end of microtubules via interaction with CAMSAP3 (PubMed:27693509). APC controls its localization to the cell membrane which is critical for its function in microtubule stabilization (PubMed:20937854).SUBCELLULAR LOCATION Localizes to the tips of microtubules.ALTERNATIVE PRODUCTS Isoform 2: Ubiquitously expressed. Isoform 1: Expressed in cell lines NCI-H460, A-549 and HaCaT. Isoform 4: Expressed in heart, lung, pituitary and placenta, not found in brain, kidney, liver, pancreas or skeletal muscle.DOMAIN The C-terminal tail is required for phosphorylation by GSK3B and for microtubule-binding.PTM Phosphorylated on serine residues in the C-terminal tail by GSK3B. Phosphorylation inhibits microtubule-binding and this plays a critical role in bulge stem cell migration and skin wound repair. Wnt-signaling can repress phosphorylation (By similarity).DISEASE The disease is caused by variants affecting the gene represented in this entry.SIMILARITY Belongs to the plakin or cytolinker family. |
| description | recommendedName: fullName evidence="24"Microtubule-actin cross-linking factor 1, isoforms 1/2/3/4/5 alternativeName: 620 kDa actin-binding protein shortName: ABP620 alternativeName: fullName evidence="22"Actin cross-linking family protein 7 alternativeName: fullName evidence="18"Macrophin-1 alternativeName: Trabeculin-alpha |
| geneName | MACF1 ABP620 ACF7 KIAA0465 KIAA0754 KIAA1251 |
| identifier | Q9UPN3 |
| isoformParent | |
| isSequenceChanged | FALSE |
| keyword | 3D-structure Acetylation Actin-binding Alternative splicing Calcium Cell membrane Cell projection Cytoplasm Cytoskeleton Disease variant Golgi apparatus Leucine-rich repeat Lissencephaly Membrane Metal-binding Microtubule Phosphoprotein Proteomics identification Reference proteome Repeat SH3 domain Wnt signaling pathway |
| modified | [InstanceEdit:9836292] Weiser, Joel, 2023-05-25 [InstanceEdit:9852000] Weiser, Joel, 2023-11-03 [InstanceEdit:9862192] Weiser, Joel, 2024-02-26 [InstanceEdit:9909836] Weiser, Joel, 2024-05-14 [InstanceEdit:9917590] Weiser, Joel, 2024-08-09 [InstanceEdit:9926675] Weiser, Joel, 2024-11-03 [InstanceEdit:9939033] Weiser, Joel, 2025-02-21 [InstanceEdit:9948485] Weiser, Joel, 2025-05-21 [InstanceEdit:9963647] Weiser, Joel, 2025-08-15 [InstanceEdit:9970787] Weiser, Joel, 2025-10-31 [InstanceEdit:9983091] Weiser, Joel, 2026-02-20 [InstanceEdit:9989145] Weiser, Joel, 2026-05-15 |
| name | MACF1 |
| referenceDatabase | [ReferenceDatabase:2] UniProt |
| referenceGene | [ReferenceDNASequence:8958029] ENSEMBL:ENSG00000127603 MACF1 [Homo sapiens] |
| secondaryIdentifier | MACF1_HUMAN B1ALC5 E9PJT0 O75053 Q5VW20 Q8WXY1 Q8WXY2 Q96PK2 Q9H540 Q9UKP0 Q9ULG9 |
| sequenceLength | 7388 |
| species | [Species:48887] Homo sapiens |
| variantIdentifier | Q9UPN3-2 |
| [Change default viewing format] | |
No pathways have been reviewed or authored by UniProt:Q9UPN3-2 MACF1 (58925)
