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Details on Person UniProt:P11226 MBL2

Class:Id	ReferenceGeneProduct:58923
_chainChangeLog	signal peptide:1-20 added on Fri February 6 2015;chain:21-248 added on Fri February 6 2015
_displayName	UniProt:P11226 MBL2
_timestamp	2026-02-20 22:23:39
chain	signal peptide:1-20 chain:21-248
checksum	C1F2AAED46D0F774
comment	FUNCTION Calcium-dependent lectin, which acts as a pattern recognition receptor that initiates the lectin pathway of the complement system, a cascade of proteins that leads to phagocytosis and breakdown of pathogens and signaling that strengthens the adaptive immune system (PubMed:14515269, PubMed:22966085, PubMed:7634089, PubMed:9087411). Specifically recognizes and binds the mannose moiety of carbohydrates on the pathogen surface, activating the MASP1 serine protease and initiating the proteolytic cascade of the lectin complement pathway (PubMed:22966085, PubMed:2573758, PubMed:6643429, PubMed:8082295, PubMed:9087411). Upon SARS coronavirus-2/SARS-CoV-2 infection, activates the complement lectin pathway which leads to the inhibition SARS-CoV-2 infection and a reduction of the induced inflammatory response (PubMed:35102342). May bind DNA (PubMed:15145932).SUBUNIT Oligomeric complex of 3 or more homotrimers (PubMed:7634089). Interacts with MASP1 and MASP2 (PubMed:22966085, PubMed:9087411). Interacts with MEP1A and MEP1B and may inhibit their catalytic activity (PubMed:16116208). Interacts with CR1 (via Sushi 24 and Sushi 25 domains) (PubMed:23460739, PubMed:29563915).SUBUNIT (Microbial infection) Interacts with SARS coronavirus-2/SARS-CoV-2 Spike glycoprotein homotrimer; the interaction is calcium-dependent and modulated by Spike glycoprotein glycosylation state.INTERACTION Specifically binds mannose moiety of carbohydrates on the surface of pathogens.TISSUE SPECIFICITY Plasma protein produced mainly in the liver.DOMAIN The coiled-coil domain mediates trimerization.POLYMORPHISM Genetic variations in MBL2 influence susceptibility to hepatitis B virus (HBV) infection [MIM:610424].POLYMORPHISM Genetic variations in MBL2 may influence susceptibility to severe COVID-19 disease caused by SARS-CoV-2 virus infection.POLYMORPHISM Genetic variations in MBL2 are responsible for mannose-binding protein deficiency [MIM:614372]. This condition is defined as MBL2 protein level of less than 100 ng/ml, is present in about 5% of people of European descent and in about 10% of sub-Saharan Africans. Most MBL2-deficient adults appear healthy, but low levels of MBL2 are associated with increased risk of infection in toddlers, in cancer patients undergoing chemotherapy, and in organ-transplant patients receiving immunosuppressive drugs, particularly recipients of liver transplants. There is an association between low levels of MBL2 and a defect of opsonization which results in susceptibility to frequent and chronic infections (PubMed:1675710). Functional MBL2 deficiency may be associated with protection against tuberculosis caused by Mycobacterium africanum but not by Mycobacterium tuberculosis, as observed in studies on Ghanaian patients with pulmonary tuberculosis (PubMed:21695215).ONLINE INFORMATION Mannose-binding protein
description	recommendedName: fullName evidence="31"Mannose-binding protein C shortName: MBP-C alternativeName: fullName evidence="28"Collectin-1 alternativeName: MBP1 alternativeName: fullName evidence="29"Mannan-binding protein alternativeName: fullName evidence="30"Mannose-binding lectin
geneName	MBL2 COLEC1 MBL
identifier	P11226
isSequenceChanged	FALSE
keyword	3D-structure Calcium Coiled coil Collagen Complement activation lectin pathway Complement pathway Direct protein sequencing Disulfide bond Hydroxylation Immunity Innate immunity Lectin Mannose-binding Metal-binding Proteomics identification Reference proteome Repeat Secreted Signal
modified	[InstanceEdit:9836292] Weiser, Joel, 2023-05-25 [InstanceEdit:9852000] Weiser, Joel, 2023-11-03 [InstanceEdit:9926675] Weiser, Joel, 2024-11-03 [InstanceEdit:9983091] Weiser, Joel, 2026-02-20
name	MBL2
referenceDatabase	[ReferenceDatabase:2] UniProt
referenceGene	[ReferenceDNASequence:8994935] ENSEMBL:ENSG00000165471 MBL2 [Homo sapiens]
secondaryIdentifier	MBL2_HUMAN Q4VB12 Q4VB13 Q4VB14 Q5SQS3 Q86SI4 Q96KE4 Q96TF7 Q96TF8 Q96TF9
sequenceLength	248
species	[Species:48887] Homo sapiens
(referenceEntity)	[EntityWithAccessionedSequence:166674] MBL2 [extracellular region] [Homo sapiens]
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No pathways have been reviewed or authored by UniProt:P11226 MBL2 (58923)