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Details on Person UniProt:Q99558 MAP3K14
| Class:Id | ReferenceGeneProduct:58907 |
|---|---|
| _chainChangeLog | chain:1-947 added on Fri February 6 2015 |
| _displayName | UniProt:Q99558 MAP3K14 |
| _timestamp | 2025-02-21 18:38:33 |
| chain | chain:1-947 |
| checksum | C9D10F67FF7F48AC |
| comment | FUNCTION Lymphotoxin beta-activated kinase which seems to be exclusively involved in the activation of NF-kappa-B and its transcriptional activity. Phosphorylates CHUK/IKKA, thereby promoting proteolytic processing of NFKB2/P100, which leads to NF-kappa-B activation via the non-canonical pathway (PubMed:25406581, PubMed:29230214). Has an essential role in the non-canonical NF-kappa-B signaling that regulates genes encoding molecules involved in B-cell survival, lymphoid organogenesis, and immune response (PubMed:25406581). Could act in a receptor-selective manner.CATALYTIC ACTIVITY L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+)CATALYTIC ACTIVITY L-threonyl-[protein] + ATP = O-phospho-L-threonyl-[protein] + ADP + H(+)SUBUNIT Interacts with TRAF2, TRAF5, TRAF6, IKKA and NFKB2/P100 (By similarity). Interacts with TRAF3 and PELI3. Interacts with NIBP; the interaction is direct. Interacts with ARRB1 and ARRB2. Interacts with GRB10. Interacts with ZFP91. Interacts with NLRP12; this interaction promotes proteasomal degradation of MAP3K14. Directly interacts with DDX3X (PubMed:30341167). Interacts (via C-terminus and kinase domain) with PPPC3A (via N-terminus) and PPP3CB (By similarity).INTERACTION Weakly expressed in testis, small intestine, spleen, thymus, peripheral blood leukocytes, prostate, ovary and colon.PTM Autophosphorylated. Phosphorylation at Thr-559 is required to activate its kinase activity and 'Lys-63'-linked polyubiquitination. Phosphorylated by CHUK/IKKA leading to MAP3K14 destabilization.PTM Ubiquitinated. Undergoes both 'Lys-48'- and 'Lys-63'-linked polyubiquitination. 'Lys-48'-linked polyubiquitination leads to its degradation by the proteasome, while 'Lys-63'-linked polyubiquitination stabilizes and activates it.DISEASE The disease is caused by variants affecting the gene represented in this entry.SIMILARITY Belongs to the protein kinase superfamily. STE Ser/Thr protein kinase family. MAP kinase kinase kinase subfamily. |
| description | recommendedName: fullName evidence="22"Mitogen-activated protein kinase kinase kinase 14 ecNumber: 2.7.11.25 alternativeName: fullName evidence="19"NF-kappa-beta-inducing kinase shortName evidence="22"HsNIK alternativeName: fullName evidence="20"Serine/threonine-protein kinase NIK |
| geneName | MAP3K14 NIK |
| identifier | Q99558 |
| isSequenceChanged | FALSE |
| keyword | 3D-structure ATP-binding Cytoplasm Disease variant Kinase Nucleotide-binding Phosphoprotein Proteomics identification Reference proteome Serine/threonine-protein kinase Transferase Ubl conjugation |
| modified | [InstanceEdit:9836292] Weiser, Joel, 2023-05-25 [InstanceEdit:9852000] Weiser, Joel, 2023-11-03 [InstanceEdit:9909836] Weiser, Joel, 2024-05-14 [InstanceEdit:9926675] Weiser, Joel, 2024-11-03 [InstanceEdit:9939033] Weiser, Joel, 2025-02-21 |
| name | MAP3K14 |
| referenceDatabase | [ReferenceDatabase:2] UniProt |
| referenceGene | [ReferenceDNASequence:9002450] ENSEMBL:ENSG00000006062 MAP3K14 [Homo sapiens] |
| secondaryIdentifier | M3K14_HUMAN A8K2D8 D3DX67 Q8IYN1 |
| sequenceLength | 947 |
| species | [Species:48887] Homo sapiens |
| (referenceEntity) | [EntityWithAccessionedSequence:168187] p-MAP3K14 [cytosol] [Homo sapiens] [EntityWithAccessionedSequence:168189] MAP3K14 [cytosol] [Homo sapiens] [EntityWithAccessionedSequence:5607646] Active NIK [cytosol] [Homo sapiens] [EntityWithAccessionedSequence:5668525] K48polyUb-NIK [cytosol] [Homo sapiens] [EntityWithAccessionedSequence:5668531] p-T559-MAP3K14 [cytosol] [Homo sapiens] |
| (referenceSequence) | [ModifiedResidue:168368] phosphorylated residue at unknown position [ModifiedResidue:5668523] O-phospho-L-threonine at 559 [GroupModifiedResidue:5668538] ubiquitinylated lysine (K48polyUb [cytosol]) at unknown position |
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No pathways have been reviewed or authored by UniProt:Q99558 MAP3K14 (58907)
