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Details on Person UniProt:O60476 MAN1A2
| Class:Id | ReferenceGeneProduct:58865 |
|---|---|
| _chainChangeLog | initiator methionine:1 added on Fri February 6 2015;chain:2-641 added on Fri February 6 2015;initiator methionine:1 for 58865 removed on Fri Nov 03 2023;initiator methionine: for 58865 added on Fri Nov 03 2023;initiator methionine: for 58865 removed on Fri Aug 15 2025;initiator methionine:1 for 58865 added on Fri Aug 15 2025 |
| _displayName | UniProt:O60476 MAN1A2 |
| _timestamp | 2025-08-15 21:01:05 |
| chain | initiator methionine:1 chain:2-641 |
| checksum | 19DA691A9C4B0ED3 |
| comment | FUNCTION Involved in the maturation of Asn-linked oligosaccharides. Progressively trim alpha-1,2-linked mannose residues from Man(9)GlcNAc(2) to produce Man(5)GlcNAc(2).CATALYTIC ACTIVITY N(4)-(alpha-D-Man-(1->2)-alpha-D-Man-(1->2)-alpha-D-Man-(1->3)-[alpha-D-Man-(1->2)-alpha-D-Man-(1->3)-[alpha-D-Man-(1->2)-alpha-D-Man-(1->6)]-alpha-D-Man-(1->6)]-beta-D-Man-(1->4)-beta-D-GlcNAc-(1->4)-beta-D-GlcNAc)-L-asparaginyl-[protein] (N-glucan mannose isomer 9A1,2,3B1,2,3) + 4 H2O = N(4)-(alpha-D-Man-(1->3)-[alpha-D-Man-(1->3)-[alpha-D-Man-(1->6)]-alpha-D-Man-(1->6)]-beta-D-Man-(1->4)-beta-D-GlcNAc-(1->4)-beta-D-GlcNAc)-L-asparaginyl-[protein] (N-glucan mannose isomer 5A1,2) + 4 beta-D-mannoseCATALYTIC ACTIVITY N(4)-(alpha-D-Man-(1->2)-alpha-D-Man-(1->2)-alpha-D-Man-(1->3)-[alpha-D-Man-(1->3)-[alpha-D-Man-(1->2)-alpha-D-Man-(1->6)]-alpha-D-Man-(1->6)]-beta-D-Man-(1->4)-beta-D-GlcNAc-(1->4)-beta-D-GlcNAc)-L-asparaginyl-[protein] (N-glucan mannose isomer 8A1,2,3B1,3) + 3 H2O = N(4)-(alpha-D-Man-(1->3)-[alpha-D-Man-(1->3)-[alpha-D-Man-(1->6)]-alpha-D-Man-(1->6)]-beta-D-Man-(1->4)-beta-D-GlcNAc-(1->4)-beta-D-GlcNAc)-L-asparaginyl-[protein] (N-glucan mannose isomer 5A1,2) + 3 beta-D-mannoseCOFACTOR Inhibited by both 1-deoxymannojirimycin and kifunensine.PATHWAY Protein modification; protein glycosylation.SUBCELLULAR LOCATION Highest levels of expression in placenta and testis.SIMILARITY Belongs to the glycosyl hydrolase 47 family. |
| description | recommendedName: Mannosyl-oligosaccharide 1,2-alpha-mannosidase IB ecNumber evidence="2"3.2.1.113 alternativeName: Mannosidase alpha class 1A member 2 alternativeName: Processing alpha-1,2-mannosidase IB shortName: Alpha-1,2-mannosidase IB |
| geneName | MAN1A2 MAN1B |
| identifier | O60476 |
| isSequenceChanged | FALSE |
| keyword | Acetylation Calcium Disulfide bond Glycoprotein Glycosidase Golgi apparatus Hydrolase Membrane Metal-binding Proteomics identification Reference proteome Signal-anchor Transmembrane Transmembrane helix |
| modified | [InstanceEdit:9836292] Weiser, Joel, 2023-05-25 [InstanceEdit:9852000] Weiser, Joel, 2023-11-03 [InstanceEdit:9926675] Weiser, Joel, 2024-11-03 [InstanceEdit:9939033] Weiser, Joel, 2025-02-21 [InstanceEdit:9963647] Weiser, Joel, 2025-08-15 |
| name | MAN1A2 |
| referenceDatabase | [ReferenceDatabase:2] UniProt |
| referenceGene | [ReferenceDNASequence:8962217] ENSEMBL:ENSG00000198162 MAN1A2 [Homo sapiens] |
| secondaryIdentifier | MA1A2_HUMAN Q9H510 |
| sequenceLength | 641 |
| species | [Species:48887] Homo sapiens |
| (referenceEntity) | [EntityWithAccessionedSequence:964747] MAN1A2 [Golgi membrane] [Homo sapiens] [EntityWithAccessionedSequence:8847486] MAN1A2 [transport vesicle] [Homo sapiens] |
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No pathways have been reviewed or authored by UniProt:O60476 MAN1A2 (58865)
