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Details on Person UniProt:P33908 MAN1A1
| Class:Id | ReferenceGeneProduct:58863 |
|---|---|
| _chainChangeLog | chain:1-653 added on Sat February 7 2015 |
| _displayName | UniProt:P33908 MAN1A1 |
| _timestamp | 2025-02-21 18:48:38 |
| chain | chain:1-653 |
| checksum | 9B164926636D8554 |
| comment | FUNCTION Involved in the maturation of Asn-linked oligosaccharides. Progressively trim alpha-1,2-linked mannose residues from Man(9)GlcNAc(2) to produce Man(5)GlcNAc(2).CATALYTIC ACTIVITY N(4)-(alpha-D-Man-(1->2)-alpha-D-Man-(1->2)-alpha-D-Man-(1->3)-[alpha-D-Man-(1->2)-alpha-D-Man-(1->3)-[alpha-D-Man-(1->2)-alpha-D-Man-(1->6)]-alpha-D-Man-(1->6)]-beta-D-Man-(1->4)-beta-D-GlcNAc-(1->4)-beta-D-GlcNAc)-L-asparaginyl-[protein] (N-glucan mannose isomer 9A1,2,3B1,2,3) + 4 H2O = N(4)-(alpha-D-Man-(1->3)-[alpha-D-Man-(1->3)-[alpha-D-Man-(1->6)]-alpha-D-Man-(1->6)]-beta-D-Man-(1->4)-beta-D-GlcNAc-(1->4)-beta-D-GlcNAc)-L-asparaginyl-[protein] (N-glucan mannose isomer 5A1,2) + 4 beta-D-mannoseCATALYTIC ACTIVITY N(4)-(alpha-D-Man-(1->2)-alpha-D-Man-(1->2)-alpha-D-Man-(1->3)-[alpha-D-Man-(1->3)-[alpha-D-Man-(1->2)-alpha-D-Man-(1->6)]-alpha-D-Man-(1->6)]-beta-D-Man-(1->4)-beta-D-GlcNAc-(1->4)-beta-D-GlcNAc)-L-asparaginyl-[protein] (N-glucan mannose isomer 8A1,2,3B1,3) + 3 H2O = N(4)-(alpha-D-Man-(1->3)-[alpha-D-Man-(1->3)-[alpha-D-Man-(1->6)]-alpha-D-Man-(1->6)]-beta-D-Man-(1->4)-beta-D-GlcNAc-(1->4)-beta-D-GlcNAc)-L-asparaginyl-[protein] (N-glucan mannose isomer 5A1,2) + 3 beta-D-mannoseCOFACTOR Inhibited by both 1-deoxymannojirimycin and kifunensine.PATHWAY Protein modification; protein glycosylation.INTERACTION Belongs to the glycosyl hydrolase 47 family. |
| description | recommendedName: Mannosyl-oligosaccharide 1,2-alpha-mannosidase IA ecNumber evidence="2"3.2.1.113 alternativeName: Man(9)-alpha-mannosidase shortName: Man9-mannosidase alternativeName: Mannosidase alpha class 1A member 1 alternativeName: Processing alpha-1,2-mannosidase IA shortName: Alpha-1,2-mannosidase IA |
| geneName | MAN1A1 |
| identifier | P33908 |
| isSequenceChanged | FALSE |
| keyword | Alternative splicing Calcium Disulfide bond Glycoprotein Glycosidase Golgi apparatus Hydrolase Membrane Proteomics identification Reference proteome Signal-anchor Transmembrane Transmembrane helix |
| modified | [InstanceEdit:9836292] Weiser, Joel, 2023-05-25 [InstanceEdit:9852000] Weiser, Joel, 2023-11-03 [InstanceEdit:9926675] Weiser, Joel, 2024-11-03 [InstanceEdit:9939033] Weiser, Joel, 2025-02-21 |
| name | MAN1A1 |
| referenceDatabase | [ReferenceDatabase:2] UniProt |
| referenceGene | [ReferenceDNASequence:8990822] ENSEMBL:ENSG00000111885 MAN1A1 [Homo sapiens] |
| secondaryIdentifier | MA1A1_HUMAN E7EU32 Q6P052 Q9NU44 Q9UJI3 |
| sequenceLength | 653 |
| species | [Species:48887] Homo sapiens |
| (isoformParent) | [ReferenceIsoform:8974347] UniProt:P33908-1 MAN1A1 [Homo sapiens] [ReferenceIsoform:8974348] UniProt:P33908-2 MAN1A1 [Homo sapiens] |
| (referenceEntity) | [EntityWithAccessionedSequence:548897] MAN1A1 [endoplasmic reticulum membrane] [Homo sapiens] [EntityWithAccessionedSequence:964767] MAN1A1 [Golgi membrane] [Homo sapiens] [EntityWithAccessionedSequence:8847488] MAN1A1 [transport vesicle] [Homo sapiens] |
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No pathways have been reviewed or authored by UniProt:P33908 MAN1A1 (58863)
