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Details on Person UniProt:Q14596 NBR1
| Class:Id | ReferenceGeneProduct:58861 |
|---|---|
| _chainChangeLog | chain:1-966 added on Sat February 7 2015 |
| _displayName | UniProt:Q14596 NBR1 |
| _timestamp | 2026-02-20 22:46:15 |
| chain | chain:1-966 |
| checksum | 6A057E67947838EF |
| comment | FUNCTION Ubiquitin-binding autophagy adapter that participates in different processes including host defense or intracellular homeostasis (PubMed:24692539, PubMed:33577621). Possesses a double function during the selective autophagy by acting as a shuttle bringing ubiquitinated proteins to autophagosomes and also by participating in the formation of protein aggregates (PubMed:24879152, PubMed:34471133, PubMed:38169523). Plays a role in the regulation of the innate immune response by modulating type I interferon production and targeting ubiquitinated IRF3 for autophagic degradation (PubMed:35914352). In response to oxidative stress, promotes an increase in SQSTM1 levels, phosphorylation, and body formation by preventing its autophagic degradation (By similarity). In turn, activates the KEAP1-NRF2/NFE2L2 antioxidant pathway (By similarity). Also plays non-autophagy role by mediating the shuttle of IL-12 to late endosome for subsequent secretion (By similarity).SUBUNIT Homooligomer and heterooligomer. Interacts with TRIM55 (By similarity). Interacts with titin/TTN (By similarity). Interacts with RNF29, USP8, MAP1LC3A, MAP1LC3B, MAP1LC3C, GABARAP, GABARAPL1 and GABARAPL2 (PubMed:19250911). Binds to ubiquitin and ubiquitinated proteins (PubMed:24692539). Interacts with SQSTM1 (PubMed:19250911). Interacts with TAX1BP1 (PubMed:33226137, PubMed:34471133). Interacts with IRF3; this interaction mediates autophagic degradation of IRF3 (PubMed:35914352). Interacts with IL12A and IL12B (By similarity). Interacts with SRBD1; this interaction clears SRBD1 through the autophagic-lysosomal pathway (PubMed:38169523).SUBUNIT (Microbial infection) Interacts with Influenza A virus protein PB1; this interaction promotes NBR1-mediated selective autophagic degradation of MAVS.INTERACTION In cardiac muscles localizes to the sarcomeric M line (By similarity). Is targeted to lysosomes for degradation (PubMed:19250911).ALTERNATIVE PRODUCTS Upon viral infection.DOMAIN The PB1 domain mediates interaction with SQSTM1.PTM (Microbial infection) Cleaved by S.pyogenes SpeB protease; leading to its degradation (PubMed:24331465). Degradation by SpeB prevents autophagy, promoting to S.pyogenes intracellular replication (PubMed:24331465).PTM Phosphorylated by GSK3A; this phosphorylation inhibits NBR1 involvement in the formation of ubiquitinated protein aggregates.CAUTION Was originally thought to be the ovarian carcinoma antigen CA125. |
| description | recommendedName: Next to BRCA1 gene 1 protein alternativeName: Cell migration-inducing gene 19 protein alternativeName: Membrane component chromosome 17 surface marker 2 alternativeName: Neighbor of BRCA1 gene 1 protein alternativeName: Protein 1A1-3B |
| geneName | NBR1 1A13B KIAA0049 M17S2 MIG19 |
| identifier | Q14596 |
| isSequenceChanged | FALSE |
| keyword | 3D-structure Alternative splicing Cytoplasm Cytoplasmic vesicle Host-virus interaction Lysosome Metal-binding Phosphoprotein Proteomics identification Reference proteome Ubl conjugation Zinc Zinc-finger |
| modified | [InstanceEdit:9836292] Weiser, Joel, 2023-05-25 [InstanceEdit:9852000] Weiser, Joel, 2023-11-03 [InstanceEdit:9917590] Weiser, Joel, 2024-08-09 [InstanceEdit:9926675] Weiser, Joel, 2024-11-03 [InstanceEdit:9948485] Weiser, Joel, 2025-05-21 [InstanceEdit:9983091] Weiser, Joel, 2026-02-20 |
| name | NBR1 |
| referenceDatabase | [ReferenceDatabase:2] UniProt |
| referenceGene | [ReferenceDNASequence:8993171] ENSEMBL:ENSG00000188554 NBR1 [Homo sapiens] |
| secondaryIdentifier | NBR1_HUMAN Q13173 Q15026 Q5J7Q8 Q96GB6 Q9NRF7 |
| sequenceLength | 966 |
| species | [Species:48887] Homo sapiens |
| (isoformParent) | [ReferenceIsoform:149980] UniProt:Q14596-2 NBR1 [Homo sapiens] [ReferenceIsoform:405728] UniProt:Q14596-1 NBR1 [Homo sapiens] |
| (referenceEntity) | [EntityWithAccessionedSequence:9665177] NBR1 [peroxisomal membrane] [Homo sapiens] [EntityWithAccessionedSequence:9665180] NBR1 [cytosol] [Homo sapiens] |
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No pathways have been reviewed or authored by UniProt:Q14596 NBR1 (58861)
