Query author contributions in Reactome
Reactome depends on collaboration between our curation team and outside experts to assemble and peer-review its pathway modules. The integration of ORCID within Reactome enables us to meet a key challenge with authoring, curating and reviewing biological information by incentivizing and crediting the external experts that contribute their expertise and time to the Reactome curation process. More information is available at ORCID and Reactome.
If you have an ORCID ID that is not listed on this page, please forward this information to us and we will update your Reactome pathway records.
Details on Person UniProt:P01717 IGLV3-25
| Class:Id | ReferenceGeneProduct:58805 |
|---|---|
| _chainChangeLog | chain:1- added on Fri February 6 2015;chain:1- removed on Fri November 4 2016;signal peptide:1-19 added on Fri November 4 2016;chain:20-112 added on Fri November 4 2016 |
| _displayName | UniProt:P01717 IGLV3-25 |
| _timestamp | 2024-11-03 20:10:39 |
| chain | signal peptide:1-19 chain:20-112 |
| checksum | 16134DD8DC7BC16A |
| comment | FUNCTION V region of the variable domain of immunoglobulin light chains that participates in the antigen recognition (PubMed:24600447). Immunoglobulins, also known as antibodies, are membrane-bound or secreted glycoproteins produced by B lymphocytes. In the recognition phase of humoral immunity, the membrane-bound immunoglobulins serve as receptors which, upon binding of a specific antigen, trigger the clonal expansion and differentiation of B lymphocytes into immunoglobulins-secreting plasma cells. Secreted immunoglobulins mediate the effector phase of humoral immunity, which results in the elimination of bound antigens (PubMed:20176268, PubMed:22158414). The antigen binding site is formed by the variable domain of one heavy chain, together with that of its associated light chain. Thus, each immunoglobulin has two antigen binding sites with remarkable affinity for a particular antigen. The variable domains are assembled by a process called V-(D)-J rearrangement and can then be subjected to somatic hypermutations which, after exposure to antigen and selection, allow affinity maturation for a particular antigen (PubMed:17576170, PubMed:20176268).SUBUNIT Immunoglobulins are composed of two identical heavy chains and two identical light chains; disulfide-linked.SUBCELLULAR LOCATION There are several alleles. The sequence shown is that of IMGT allele IGLV3-25*03.CAUTION For an example of a full-length immunoglobulin lambda light chain see AC P0DOX8. |
| description | recommendedName: fullName evidence="4 9"Immunoglobulin lambda variable 3-25 alternativeName: fullName evidence="11"Ig lambda chain V-IV region Hil |
| geneName | IGLV3-25 |
| identifier | P01717 |
| isSequenceChanged | FALSE |
| keyword | Adaptive immunity Cell membrane Direct protein sequencing Disulfide bond Immunity Immunoglobulin Immunoglobulin domain Membrane Proteomics identification Reference proteome Secreted Signal |
| modified | [InstanceEdit:9836292] Weiser, Joel, 2023-05-25 [InstanceEdit:9852000] Weiser, Joel, 2023-11-03 [InstanceEdit:9917590] Weiser, Joel, 2024-08-09 [InstanceEdit:9926675] Weiser, Joel, 2024-11-03 |
| name | IGLV3-25 |
| referenceDatabase | [ReferenceDatabase:2] UniProt |
| referenceGene | [ReferenceDNASequence:9004790] ENSEMBL:ENSG00000211659 IGLV3-25 [Homo sapiens] |
| secondaryIdentifier | LV325_HUMAN A0A075B6J4 |
| sequenceLength | 112 |
| species | [Species:48887] Homo sapiens |
| (referenceEntity) | [EntityWithAccessionedSequence:983575] Ig lambda chain V-IV region Hil [extracellular region] [Homo sapiens] [EntityWithAccessionedSequence:2038770] Ig lambda chain V-IV region Hil [plasma membrane] [Homo sapiens] |
| [Change default viewing format] | |
No pathways have been reviewed or authored by UniProt:P01717 IGLV3-25 (58805)
