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Details on Person UniProt:P80748 IGLV3-21

Class:Id	ReferenceGeneProduct:58799
_chainChangeLog	chain:1- added on Sat February 7 2015;chain:1- removed on Fri November 4 2016;signal peptide:1-17 added on Fri November 4 2016;chain:18-117 added on Fri November 4 2016
_displayName	UniProt:P80748 IGLV3-21
_timestamp	2024-11-03 19:57:07
chain	signal peptide:1-17 chain:18-117
checksum	B678ABFF5F22FDED
comment	FUNCTION V region of the variable domain of immunoglobulin light chains that participates in the antigen recognition (PubMed:24600447). Immunoglobulins, also known as antibodies, are membrane-bound or secreted glycoproteins produced by B lymphocytes. In the recognition phase of humoral immunity, the membrane-bound immunoglobulins serve as receptors which, upon binding of a specific antigen, trigger the clonal expansion and differentiation of B lymphocytes into immunoglobulins-secreting plasma cells. Secreted immunoglobulins mediate the effector phase of humoral immunity, which results in the elimination of bound antigens (PubMed:20176268, PubMed:22158414). The antigen binding site is formed by the variable domain of one heavy chain, together with that of its associated light chain. Thus, each immunoglobulin has two antigen binding sites with remarkable affinity for a particular antigen. The variable domains are assembled by a process called V-(D)-J rearrangement and can then be subjected to somatic hypermutations which, after exposure to antigen and selection, allow affinity maturation for a particular antigen (PubMed:17576170, PubMed:20176268).SUBUNIT Immunoglobulins are composed of two identical heavy chains and two identical light chains; disulfide-linked.SUBCELLULAR LOCATION There are several alleles. The sequence shown is that of IMGT allele IGLV3-21*02.CAUTION For an example of a full-length immunoglobulin lambda light chain see AC P0DOX8.
description	recommendedName: fullName evidence="4 9"Immunoglobulin lambda variable 3-21 alternativeName: fullName evidence="11"Ig lambda chain V-III region LOI alternativeName: fullName evidence="12"Ig lambda chain V-V region DEL alternativeName: fullName evidence="13"Ig lambda chain V-VII region MOT
geneName	IGLV3-21
identifier	P80748
isSequenceChanged	FALSE
keyword	Adaptive immunity Cell membrane Direct protein sequencing Disulfide bond Immunity Immunoglobulin Immunoglobulin domain Membrane Proteomics identification Reference proteome Secreted Signal
modified	[InstanceEdit:9836292] Weiser, Joel, 2023-05-25 [InstanceEdit:9852000] Weiser, Joel, 2023-11-03 [InstanceEdit:9917590] Weiser, Joel, 2024-08-09 [InstanceEdit:9926675] Weiser, Joel, 2024-11-03
name	IGLV3-21
referenceDatabase	[ReferenceDatabase:2] UniProt
referenceGene	[ReferenceDNASequence:8988486] ENSEMBL:ENSG00000211662 IGLV3-21 [Homo sapiens]
secondaryIdentifier	LV321_HUMAN A0A075B6J7 P01719 P01720
sequenceLength	117
species	[Species:48887] Homo sapiens
(referenceEntity)	[EntityWithAccessionedSequence:983652] Ig lambda chain V-III region LOI [extracellular region] [Homo sapiens] [EntityWithAccessionedSequence:2038758] Ig lambda chain V-III region LOI [plasma membrane] [Homo sapiens]
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No pathways have been reviewed or authored by UniProt:P80748 IGLV3-21 (58799)