Query author contributions in Reactome
Reactome depends on collaboration between our curation team and outside experts to assemble and peer-review its pathway modules. The integration of ORCID within Reactome enables us to meet a key challenge with authoring, curating and reviewing biological information by incentivizing and crediting the external experts that contribute their expertise and time to the Reactome curation process. More information is available at ORCID and Reactome.
If you have an ORCID ID that is not listed on this page, please forward this information to us and we will update your Reactome pathway records.
Details on Person UniProt:P01699 IGLV1-44
| Class:Id | ReferenceGeneProduct:58755 |
|---|---|
| _chainChangeLog | chain:1- added on Fri February 6 2015;chain:1- removed on Fri November 4 2016;signal peptide:1-19 added on Fri November 4 2016;chain:20-117 added on Fri November 4 2016 |
| _displayName | UniProt:P01699 IGLV1-44 |
| _timestamp | 2024-11-03 20:01:43 |
| chain | signal peptide:1-19 chain:20-117 |
| checksum | 5302215AD2E70E7C |
| comment | FUNCTION V region of the variable domain of immunoglobulin light chains that participates in the antigen recognition (PubMed:24600447). Immunoglobulins, also known as antibodies, are membrane-bound or secreted glycoproteins produced by B lymphocytes. In the recognition phase of humoral immunity, the membrane-bound immunoglobulins serve as receptors which, upon binding of a specific antigen, trigger the clonal expansion and differentiation of B lymphocytes into immunoglobulins-secreting plasma cells. Secreted immunoglobulins mediate the effector phase of humoral immunity, which results in the elimination of bound antigens (PubMed:20176268, PubMed:22158414). The antigen binding site is formed by the variable domain of one heavy chain, together with that of its associated light chain. Thus, each immunoglobulin has two antigen binding sites with remarkable affinity for a particular antigen. The variable domains are assembled by a process called V-(D)-J rearrangement and can then be subjected to somatic hypermutations which, after exposure to antigen and selection, allow affinity maturation for a particular antigen (PubMed:17576170, PubMed:20176268).SUBUNIT Immunoglobulins are composed of two identical heavy chains and two identical light chains; disulfide-linked.SUBCELLULAR LOCATION There are several alleles. The sequence shown is that of IMGT allele IGLV1-44*01.CAUTION For an example of a full-length immunoglobulin lambda light chain see AC P0DOX8. |
| description | recommendedName: fullName evidence="6 11"Immunoglobulin lambda variable 1-44 alternativeName: fullName evidence="13"Ig lambda chain V-I region MEM alternativeName: fullName evidence="14"Ig lambda chain V-I region VOR |
| geneName | IGLV1-44 |
| identifier | P01699 |
| isSequenceChanged | FALSE |
| keyword | Adaptive immunity Cell membrane Direct protein sequencing Disulfide bond Immunity Immunoglobulin Immunoglobulin domain Membrane Proteomics identification Pyrrolidone carboxylic acid Reference proteome Secreted Signal |
| modified | [InstanceEdit:84067] Schmidt, EE, 2003-12-18 04:29:09 [InstanceEdit:143527] Schmidt, EE, 2004-11-12 07:45:10 [InstanceEdit:217385] Schmidt, EE, 2008-03-27 06:23:53 [InstanceEdit:354386] Schmidt, EE, 2008-06-18 04:45:12 [InstanceEdit:384350] Kanapin, AA, 2008-11-26 14:00:39 [InstanceEdit:392885] Kanapin, AA, 2009-03-09 12:07:18 [InstanceEdit:400710] Schmidt, EE, 2009-03-25 05:33:35 [InstanceEdit:423310] Kanapin, AA [InstanceEdit:435478] Kanapin, AA [InstanceEdit:435871] Kanapin, AA [InstanceEdit:447347] Kanapin, AA [InstanceEdit:525883] Kanapin, AA [InstanceEdit:613449] Kanapin, AA [InstanceEdit:797602] Kanapin, AA [InstanceEdit:937368] Yung, CK [InstanceEdit:1042053] Yung, CK [InstanceEdit:1220657] Yung, CK [InstanceEdit:1300696] Yung, CK [InstanceEdit:1301627] Yung, CK [InstanceEdit:1551960] Weiser, JD [InstanceEdit:1995863] Weiser, JD [InstanceEdit:2132304] Weiser, JD [InstanceEdit:2265580] Weiser, JD [InstanceEdit:5433710] Weiser, JD [InstanceEdit:5618415] Weiser, JD [InstanceEdit:5634237] Weiser, JD [InstanceEdit:5673015] Weiser, JD [InstanceEdit:5691543] Weiser, JD [InstanceEdit:6791590] Weiser, JD [InstanceEdit:6807888] Weiser, JD [InstanceEdit:8856987] Weiser, JD [InstanceEdit:8869714] Weiser, JD [InstanceEdit:8934940] Weiser, JD [InstanceEdit:8944791] Weiser, JD [InstanceEdit:8964659] Weiser, JD [InstanceEdit:8987656] Weiser, JD [InstanceEdit:9037114] Weiser, JD [InstanceEdit:9637257] Weiser, JD [InstanceEdit:9657908] Weiser, JD [InstanceEdit:9676415] Weiser, JD [InstanceEdit:9715482] Weiser, JD [InstanceEdit:9750299] Weiser, JD [InstanceEdit:9852000] Weiser, Joel, 2023-11-03 [InstanceEdit:9917590] Weiser, Joel, 2024-08-09 [InstanceEdit:9926675] Weiser, Joel, 2024-11-03 |
| name | IGLV1-44 |
| referenceDatabase | [ReferenceDatabase:2] UniProt |
| referenceGene | [ReferenceDNASequence:9000139] ENSEMBL:ENSG00000211651 IGLV1-44 [Homo sapiens] |
| secondaryIdentifier | LV144_HUMAN A0A0B4J1U1 A0A0G2JQC2 A0A0U1RVH6 P06887 |
| sequenceLength | 117 |
| species | [Species:48887] Homo sapiens |
| (referenceEntity) | [EntityWithAccessionedSequence:983543] Ig lambda chain V-I region VOR [extracellular region] [Homo sapiens] [EntityWithAccessionedSequence:2038756] Ig lambda chain V-I region VOR [plasma membrane] [Homo sapiens] |
| [Change default viewing format] | |
No pathways have been reviewed or authored by UniProt:P01699 IGLV1-44 (58755)
