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Details on Person UniProt:Q16787 LAMA3
| Class:Id | ReferenceGeneProduct:58613 |
|---|---|
| _chainChangeLog | signal peptide:1-35 added on Fri February 6 2015;chain:36-3333 added on Fri February 6 2015 |
| _displayName | UniProt:Q16787 LAMA3 |
| _timestamp | 2024-11-03 20:19:46 |
| chain | signal peptide:1-35 chain:36-3333 |
| checksum | 6F99AF4D4B99FCB0 |
| comment | FUNCTION Binding to cells via a high affinity receptor, laminin is thought to mediate the attachment, migration and organization of cells into tissues during embryonic development by interacting with other extracellular matrix components.FUNCTION Laminin-5 is thought to be involved in (1) cell adhesion via integrin alpha-3/beta-1 in focal adhesion and integrin alpha-6/beta-4 in hemidesmosomes, (2) signal transduction via tyrosine phosphorylation of pp125-FAK and p80, (3) differentiation of keratinocytes.SUBUNIT Laminin is a complex glycoprotein, consisting of three different polypeptide chains (alpha, beta, gamma), which are bound to each other by disulfide bonds into a cross-shaped molecule comprising one long and three short arms with globules at each end. Alpha-3 is a subunit of laminin-5 (laminin-332 or epiligrin/kalinin/nicein), laminin-6 (laminin-311 or K-laminin) and laminin-7 (laminin-321 or KS-laminin).SUBCELLULAR LOCATION Major component.ALTERNATIVE PRODUCTS Skin; respiratory, urinary, and digestive epithelia and in other specialized tissues with prominent secretory or protective functions. Epithelial basement membrane, and epithelial cell tongue that migrates into a wound bed. A differential and focal expression of the subunit alpha-3 is observed in the CNS.INDUCTION Laminin-5 is up-regulated in wound sites of human skin.DOMAIN The alpha-helical domains I and II are thought to interact with other laminin chains to form a coiled coil structure.DOMAIN Domain G is globular.DISEASE The disease is caused by variants affecting the gene represented in this entry.DISEASE The disease is caused by variants affecting the gene represented in this entry.DISEASE The disease is caused by variants affecting the gene represented in this entry. |
| description | recommendedName: Laminin subunit alpha-3 alternativeName: Epiligrin 170 kDa subunit shortName: E170 alternativeName: Epiligrin subunit alpha alternativeName: Kalinin subunit alpha alternativeName: Laminin-5 subunit alpha alternativeName: Laminin-6 subunit alpha alternativeName: Laminin-7 subunit alpha alternativeName: Nicein subunit alpha |
| geneName | LAMA3 LAMNA |
| identifier | Q16787 |
| isSequenceChanged | FALSE |
| keyword | Alternative splicing Basement membrane Cell adhesion Coiled coil Disease variant Disulfide bond Epidermolysis bullosa Extracellular matrix Glycoprotein Laminin EGF-like domain Proteomics identification Reference proteome Repeat Secreted Signal |
| modified | [InstanceEdit:9836292] Weiser, Joel, 2023-05-25 [InstanceEdit:9852000] Weiser, Joel, 2023-11-03 [InstanceEdit:9926675] Weiser, Joel, 2024-11-03 |
| name | LAMA3 |
| referenceDatabase | [ReferenceDatabase:2] UniProt |
| referenceGene | [ReferenceDNASequence:8960273] ENSEMBL:ENSG00000053747 LAMA3 [Homo sapiens] |
| secondaryIdentifier | LAMA3_HUMAN B0YJ33 Q13679 Q13680 Q6VU67 Q6VU68 Q6VU69 Q76E14 Q96TG0 |
| sequenceLength | 3333 |
| species | [Species:48887] Homo sapiens |
| (isoformParent) | [ReferenceIsoform:149733] UniProt:Q16787-2 LAMA3 [Homo sapiens] [ReferenceIsoform:405937] UniProt:Q16787-1 LAMA3 [Homo sapiens] [ReferenceIsoform:8967911] UniProt:Q16787-3 LAMA3 [Homo sapiens] [ReferenceIsoform:8967912] UniProt:Q16787-4 LAMA3 [Homo sapiens] |
| (referenceEntity) | [EntityWithAccessionedSequence:445991] LAMA3 [extracellular region] [Homo sapiens] [EntityWithAccessionedSequence:2533899] LAMA3(36-?) [extracellular region] [Homo sapiens] [EntityWithAccessionedSequence:2533924] LAMA3(?-3333) [extracellular region] [Homo sapiens] |
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No pathways have been reviewed or authored by UniProt:Q16787 LAMA3 (58613)
