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Details on Person UniProt:P25391 LAMA1
| Class:Id | ReferenceGeneProduct:58609 |
|---|---|
| _chainChangeLog | signal peptide:1-17 added on Sat February 7 2015;chain:18-3075 added on Sat February 7 2015 |
| _displayName | UniProt:P25391 LAMA1 |
| _timestamp | 2026-02-20 21:50:30 |
| chain | signal peptide:1-17 chain:18-3075 |
| checksum | 941167F8FE534745 |
| comment | FUNCTION Binding to cells via a high affinity receptor, laminin is thought to mediate the attachment, migration and organization of cells into tissues during embryonic development by interacting with other extracellular matrix components. As a ligand for alpha-dystroglycan, it is involved in a number of processes including epithelium branching morphogenesis, down-regulation of apoptotic signals in muscle via the activation of PI3K/AKT signaling, and activation of RAC1 signaling. As a subunit of laminin-1 (also known as laminin-111 or EHS laminin), it is involved in the stimulation of agrin-induced receptor clustering through a MuSK-independent pathway.SUBUNIT Laminin is a complex glycoprotein, consisting of three different polypeptide chains (alpha, beta, gamma), which are bound to each other by disulfide bonds into a cross-shaped molecule comprising one long and three short arms with globules at each end. Alpha-1 is a subunit of laminin-1 (laminin-111 or EHS laminin) and laminin-3 (laminin-121 or S-laminin). Interacts with alpha-dystroglycan; the interaction is required for a number of processes including epithelium branching morphogenesis, and down-regulation of apoptotic signals in muscle via the activation of PI3K/AKT signaling.INTERACTION The alpha-helical domains I and II are thought to interact with other laminin chains to form a coiled coil structure.DOMAIN Domains VI, IV and G are globular.PTM Tyrosine phosphorylated by PKDCC/VLK.DISEASE The disease is caused by variants affecting the gene represented in this entry. |
| description | recommendedName: Laminin subunit alpha-1 alternativeName: Laminin A chain alternativeName: Laminin-1 subunit alpha alternativeName: Laminin-3 subunit alpha alternativeName: S-laminin subunit alpha shortName: S-LAM alpha |
| geneName | LAMA1 LAMA |
| identifier | P25391 |
| isSequenceChanged | FALSE |
| keyword | Basement membrane Cell adhesion Coiled coil Disulfide bond Extracellular matrix Glycoprotein Laminin EGF-like domain Phosphoprotein Proteomics identification Reference proteome Repeat Secreted Signal |
| modified | [InstanceEdit:9836292] Weiser, Joel, 2023-05-25 [InstanceEdit:9852000] Weiser, Joel, 2023-11-03 [InstanceEdit:9926675] Weiser, Joel, 2024-11-03 [InstanceEdit:9983091] Weiser, Joel, 2026-02-20 |
| name | LAMA1 |
| referenceDatabase | [ReferenceDatabase:2] UniProt |
| referenceGene | [ReferenceDNASequence:8998398] ENSEMBL:ENSG00000101680 LAMA1 [Homo sapiens] |
| secondaryIdentifier | LAMA1_HUMAN |
| sequenceLength | 3075 |
| species | [Species:48887] Homo sapiens |
| (referenceEntity) | [EntityWithAccessionedSequence:201602] LAMA1 [cytosol] [Homo sapiens] [EntityWithAccessionedSequence:215953] LAMA1 [extracellular region] [Homo sapiens] [EntityWithAccessionedSequence:2533886] LAMA1(18-?) [extracellular region] [Homo sapiens] [EntityWithAccessionedSequence:2533888] LAMA1(?-3075) [extracellular region] [Homo sapiens] |
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No pathways have been reviewed or authored by UniProt:P25391 LAMA1 (58609)
