Query author contributions in Reactome
Reactome depends on collaboration between our curation team and outside experts to assemble and peer-review its pathway modules. The integration of ORCID within Reactome enables us to meet a key challenge with authoring, curating and reviewing biological information by incentivizing and crediting the external experts that contribute their expertise and time to the Reactome curation process. More information is available at ORCID and Reactome.
If you have an ORCID ID that is not listed on this page, please forward this information to us and we will update your Reactome pathway records.
Details on Person UniProt:P16233 PNLIP
| Class:Id | ReferenceGeneProduct:58591 |
|---|---|
| _chainChangeLog | signal peptide:1-16 added on Sat February 7 2015;chain:17-465 added on Sat February 7 2015 |
| _displayName | UniProt:P16233 PNLIP |
| _timestamp | 2026-02-20 23:07:13 |
| chain | signal peptide:1-16 chain:17-465 |
| checksum | 2BC49CC7F0E2DF52 |
| comment | FUNCTION Plays an important role in fat metabolism. It preferentially splits the esters of long-chain fatty acids at positions 1 and 3, producing mainly 2-monoacylglycerol and free fatty acids, and shows considerably higher activity against insoluble emulsified substrates than against soluble ones.CATALYTIC ACTIVITY a triacylglycerol + H2O = a diacylglycerol + a fatty acid + H(+)CATALYTIC ACTIVITY 1,2,3-tributanoylglycerol + H2O = dibutanoylglycerol + butanoate + H(+)CATALYTIC ACTIVITY 1,2,3-tri-(9Z-octadecenoyl)-glycerol + H2O = di-(9Z)-octadecenoylglycerol + (9Z)-octadecenoate + H(+)CATALYTIC ACTIVITY all-trans-retinyl hexadecanoate + H2O = all-trans-retinol + hexadecanoate + H(+)CATALYTIC ACTIVITY 1,2-di-(9Z-octadecenoyl)-glycerol + H2O = (9Z-octadecenoyl)-glycerol + (9Z)-octadecenoate + H(+)ACTIVITY REGULATION Inhibited by bile salts, is reactivated by (pro)colipase/CLPS.BIOPHYSICOCHEMICAL PROPERTIES Optimum pH is 7.SUBUNIT Forms a 1:1 stoichiometric complex with (pro)colipase/CLPS.INTERACTION The disease is caused by variants affecting the gene represented in this entry.SIMILARITY Belongs to the AB hydrolase superfamily. Lipase family.ONLINE INFORMATION Pancreatic lipase entry |
| description | recommendedName: fullName evidence="7"Pancreatic triacylglycerol lipase shortName: PL shortName: PTL shortName: Pancreatic lipase ecNumber evidence="2"3.1.1.3 |
| geneName | PNLIP |
| identifier | P16233 |
| isSequenceChanged | FALSE |
| keyword | 3D-structure Calcium Disease variant Disulfide bond Glycoprotein Hydrolase Lipid degradation Lipid metabolism Metal-binding Proteomics identification Reference proteome Secreted Signal |
| modified | [InstanceEdit:9836292] Weiser, Joel, 2023-05-25 [InstanceEdit:9852000] Weiser, Joel, 2023-11-03 [InstanceEdit:9926675] Weiser, Joel, 2024-11-03 [InstanceEdit:9939033] Weiser, Joel, 2025-02-21 [InstanceEdit:9983091] Weiser, Joel, 2026-02-20 |
| name | PNLIP |
| referenceDatabase | [ReferenceDatabase:2] UniProt |
| referenceGene | [ReferenceDNASequence:9001875] ENSEMBL:ENSG00000175535 PNLIP [Homo sapiens] |
| secondaryIdentifier | LIPP_HUMAN Q5VSQ2 |
| sequenceLength | 465 |
| species | [Species:48887] Homo sapiens |
| (referenceEntity) | [EntityWithAccessionedSequence:192419] PNLIP [extracellular region] [Homo sapiens] [EntityWithAccessionedSequence:9922845] PNLIP [zymogen granule] [Homo sapiens] |
| [Change default viewing format] | |
No pathways have been reviewed or authored by UniProt:P16233 PNLIP (58591)
