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Details on Person UniProt:P11150 LIPC
| Class:Id | ReferenceGeneProduct:58587 |
|---|---|
| _chainChangeLog | signal peptide:1-22 added on Fri February 6 2015;chain:23-499 added on Fri February 6 2015 |
| _displayName | UniProt:P11150 LIPC |
| _timestamp | 2025-02-21 19:08:53 |
| chain | signal peptide:1-22 chain:23-499 |
| checksum | 1FC7567CAE3E514B |
| comment | FUNCTION Catalyzes the hydrolysis of triglycerides and phospholipids present in circulating plasma lipoproteins, including chylomicrons, intermediate density lipoproteins (IDL), low density lipoproteins (LDL) of large size and high density lipoproteins (HDL), releasing free fatty acids (FFA) and smaller lipoprotein particles (PubMed:12032167, PubMed:26193433, PubMed:7592706, PubMed:8798474). Also exhibits lysophospholipase activity (By similarity). Can hydrolyze both neutral lipid and phospholipid substrates but shows a greater binding affinity for neutral lipid substrates than phospholipid substrates (By similarity). In native LDL, preferentially hydrolyzes the phosphatidylcholine species containing polyunsaturated fatty acids at sn-2 position (PubMed:26193433).CATALYTIC ACTIVITY a triacylglycerol + H2O = a diacylglycerol + a fatty acid + H(+)CATALYTIC ACTIVITY a 1-acyl-sn-glycero-3-phosphocholine + H2O = sn-glycerol 3-phosphocholine + a fatty acid + H(+)CATALYTIC ACTIVITY a 1,2-diacyl-sn-glycero-3-phosphocholine + H2O = a 2-acyl-sn-glycero-3-phosphocholine + a fatty acid + H(+)CATALYTIC ACTIVITY 1,2,3-tri-(9Z-octadecenoyl)-glycerol + H2O = di-(9Z)-octadecenoylglycerol + (9Z)-octadecenoate + H(+)CATALYTIC ACTIVITY 1,2-di-(9Z-octadecenoyl)-sn-glycero-3-phosphocholine + H2O = (9Z-octadecenoyl)-sn-glycero-3-phosphocholine + (9Z)-octadecenoate + H(+)CATALYTIC ACTIVITY 1,2,3-tributanoylglycerol + H2O = dibutanoylglycerol + butanoate + H(+)CATALYTIC ACTIVITY 1,2-dihexadecanoyl-sn-glycero-3-phosphocholine + H2O = hexadecanoyl-sn-glycero-3-phosphocholine + hexadecanoate + H(+)CATALYTIC ACTIVITY 1,2-di-(9Z-octadecenoyl)-sn-glycerol + H2O = 2-(9Z-octadecenoyl)-glycerol + (9Z)-octadecenoate + H(+)CATALYTIC ACTIVITY 1,2,3-tri-(9Z-octadecenoyl)-glycerol + H2O = 2,3-di-(9Z)-octadecenoyl-sn-glycerol + (9Z)-octadecenoate + H(+)CATALYTIC ACTIVITY 1-(9Z-octadecenoyl)-sn-glycero-3-phospho-L-serine + H2O = sn-glycero-3-phospho-L-serine + (9Z)-octadecenoate + H(+)CATALYTIC ACTIVITY 1-hexadecanoyl-sn-glycero-3-phosphocholine + H2O = sn-glycerol 3-phosphocholine + hexadecanoate + H(+)CATALYTIC ACTIVITY 1,3-di-(9Z-octadecenoyl)-glycerol + H2O = 3-(9Z-octadecenoyl)-sn-glycerol + (9Z)-octadecenoate + H(+)ACTIVITY REGULATION Phospholipase A1 and triacylglycerol lipase are inhibited by sphingomyelin.BIOPHYSICOCHEMICAL PROPERTIES Homodimer.SUBCELLULAR LOCATION Genetic variations in LIPC define the high density lipoprotein cholesterol level quantitative trait locus 12 (HDLCQ12) [MIM:612797].POLYMORPHISM Genetic variations in LIPC are associated with susceptibility to type 2 diabetes mellitus (T2D) [MIM:125853].DISEASE The disease is caused by variants affecting the gene represented in this entry.SIMILARITY Belongs to the AB hydrolase superfamily. Lipase family. |
| description | recommendedName: Hepatic triacylglycerol lipase shortName: HL shortName: Hepatic lipase ecNumber evidence="8 18 21 22"3.1.1.3 alternativeName: Lipase member C alternativeName: Lysophospholipase ecNumber evidence="2"3.1.1.5 alternativeName: Phospholipase A1 ecNumber evidence="8 18 21"3.1.1.32 |
| geneName | LIPC HTGL |
| identifier | P11150 |
| isSequenceChanged | FALSE |
| keyword | Direct protein sequencing Disease variant Glycoprotein HDL Heparin-binding Hydrolase Lipid degradation Lipid metabolism Proteomics identification Reference proteome Secreted Signal |
| modified | [InstanceEdit:9836292] Weiser, Joel, 2023-05-25 [InstanceEdit:9852000] Weiser, Joel, 2023-11-03 [InstanceEdit:9917590] Weiser, Joel, 2024-08-09 [InstanceEdit:9926675] Weiser, Joel, 2024-11-03 [InstanceEdit:9939033] Weiser, Joel, 2025-02-21 |
| name | LIPC |
| referenceDatabase | [ReferenceDatabase:2] UniProt |
| referenceGene | [ReferenceDNASequence:9001874] ENSEMBL:ENSG00000166035 LIPC [Homo sapiens] |
| secondaryIdentifier | LIPC_HUMAN A2RUB4 A8K9B6 O43571 P78529 Q99465 |
| sequenceLength | 499 |
| species | [Species:48887] Homo sapiens |
| (referenceEntity) | [EntityWithAccessionedSequence:174603] LIPC [extracellular matrix] [Homo sapiens] [EntityWithAccessionedSequence:5694065] LIPC [extracellular region] [Homo sapiens] [EntityWithAccessionedSequence:6785172] LIPC [endoplasmic reticulum lumen] [Homo sapiens] |
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No pathways have been reviewed or authored by UniProt:P11150 LIPC (58587)
