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Details on Person UniProt:Q8WXD0 RXFP2
| Class:Id | ReferenceGeneProduct:58541 |
|---|---|
| _chainChangeLog | chain:1-754 added on Fri February 6 2015 |
| _displayName | UniProt:Q8WXD0 RXFP2 |
| _timestamp | 2023-11-03 15:52:05 |
| chain | chain:1-754 |
| checksum | 2088ECD204C6A6C5 |
| comment | FUNCTION Receptor for relaxin. The activity of this receptor is mediated by G proteins leading to stimulation of adenylate cyclase and an increase of cAMP. May also be a receptor for Leydig insulin-like peptide (INSL3).SUBCELLULAR LOCATION Expressed mainly in the brain, kidney, muscle, testis, thyroid, uterus, peripheral blood cells and bone marrow.DISEASE The disease is caused by variants affecting the gene represented in this entry.SIMILARITY Belongs to the G-protein coupled receptor 1 family.CAUTION It is uncertain whether Met-1 or Met-18 is the initiator. |
| description | recommendedName: Relaxin receptor 2 alternativeName: G-protein coupled receptor 106 alternativeName: G-protein coupled receptor affecting testicular descent alternativeName: Leucine-rich repeat-containing G-protein coupled receptor 8 alternativeName: Relaxin family peptide receptor 2 |
| geneName | RXFP2 GPR106 GREAT LGR8 |
| identifier | Q8WXD0 |
| isSequenceChanged | FALSE |
| keyword | 3D-structure Alternative splicing Cell membrane Disease variant Disulfide bond G-protein coupled receptor Glycoprotein Leucine-rich repeat Membrane Receptor Reference proteome Repeat Transducer Transmembrane Transmembrane helix |
| modified | [InstanceEdit:9836292] Weiser, Joel, 2023-05-25 [InstanceEdit:9852000] Weiser, Joel, 2023-11-03 |
| name | RXFP2 |
| referenceDatabase | [ReferenceDatabase:2] UniProt |
| referenceGene | [ReferenceDNASequence:8997975] ENSEMBL:ENSG00000133105 RXFP2 [Homo sapiens] |
| secondaryIdentifier | RXFP2_HUMAN B1ALE9 Q3KU23 |
| sequenceLength | 754 |
| species | [Species:48887] Homo sapiens |
| (isoformParent) | [ReferenceIsoform:8968512] UniProt:Q8WXD0-1 RXFP2 [Homo sapiens] [ReferenceIsoform:8968513] UniProt:Q8WXD0-2 RXFP2 [Homo sapiens] |
| (referenceEntity) | [EntityWithAccessionedSequence:444844] RXFP2 [plasma membrane] [Homo sapiens] |
| [Change default viewing format] | |
No pathways have been reviewed or authored by UniProt:Q8WXD0 RXFP2 (58541)
