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Details on Person UniProt:Q99538 LGMN

Class:Id	ReferenceGeneProduct:58529
_chainChangeLog	signal peptide:1-17 added on Fri February 6 2015;chain:18-323 added on Fri February 6 2015;propeptide:324-433 added on Fri February 6 2015
_displayName	UniProt:Q99538 LGMN
_timestamp	2024-11-03 20:01:38
chain	signal peptide:1-17 chain:18-323 propeptide:324-433
checksum	081AD2D0D584E72A
comment	FUNCTION Has a strict specificity for hydrolysis of asparaginyl bonds (PubMed:23776206). Can also cleave aspartyl bonds slowly, especially under acidic conditions (PubMed:23776206). Involved in the processing of proteins for MHC class II antigen presentation in the lysosomal/endosomal system (PubMed:9872320). Also involved in MHC class I antigen presentation in cross-presenting dendritic cells by mediating cleavage and maturation of Perforin-2 (MPEG1), thereby promoting antigen translocation in the cytosol (By similarity). Required for normal lysosomal protein degradation in renal proximal tubules (By similarity). Required for normal degradation of internalized EGFR (By similarity). Plays a role in the regulation of cell proliferation via its role in EGFR degradation (By similarity).CATALYTIC ACTIVITY Hydrolysis of proteins and small molecule substrates at -Asn-\|-Xaa- bonds.ACTIVITY REGULATION Inhibited by CST6.BIOPHYSICOCHEMICAL PROPERTIES Optimum pH is 5.5 for the free enzyme, and pH 6 in the presence of bound integrins.SUBUNIT Homodimer before autocatalytic removal of the propeptide (PubMed:23776206). Monomer after autocatalytic processing (PubMed:23776206). May interact with integrins (PubMed:23776206).INTERACTION Ubiquitous. Particularly abundant in kidney, heart and placenta.DOMAIN In the zymogen form, the uncleaved propeptide blocks access to the active site.PTM Activated by autocatalytic processing at pH 4.SIMILARITY Belongs to the peptidase C13 family.
description	recommendedName: fullName evidence="11"Legumain ecNumber evidence="5 8"3.4.22.34 alternativeName: fullName evidence="12"Asparaginyl endopeptidase shortName evidence="12"AEP alternativeName: fullName evidence="10"Protease, cysteine 1
geneName	LGMN PRSC1
identifier	Q99538
isSequenceChanged	FALSE
keyword	3D-structure Alternative splicing Direct protein sequencing Disulfide bond Glycoprotein Hydrolase Lysosome Protease Proteomics identification Reference proteome Signal Thiol protease Zymogen
modified	[InstanceEdit:9836292] Weiser, Joel, 2023-05-25 [InstanceEdit:9852000] Weiser, Joel, 2023-11-03 [InstanceEdit:9862192] Weiser, Joel, 2024-02-26 [InstanceEdit:9926675] Weiser, Joel, 2024-11-03
name	LGMN
referenceDatabase	[ReferenceDatabase:2] UniProt
referenceGene	[ReferenceDNASequence:8960117] ENSEMBL:ENSG00000100600 LGMN [Homo sapiens]
secondaryIdentifier	LGMN_HUMAN O00123 Q86TV2 Q86TV3 Q9BTY1
sequenceLength	433
species	[Species:48887] Homo sapiens
(isoformParent)	[ReferenceIsoform:8977904] UniProt:Q99538-1 LGMN [Homo sapiens] [ReferenceIsoform:8977905] UniProt:Q99538-2 LGMN [Homo sapiens] [ReferenceIsoform:8977906] UniProt:Q99538-3 LGMN [Homo sapiens]
(referenceEntity)	[EntityWithAccessionedSequence:350135] LGMN [lysosomal lumen] [Homo sapiens] [EntityWithAccessionedSequence:8942384] LGMN [endolysosome lumen] [Homo sapiens] [EntityWithAccessionedSequence:8960664] LGMN [extracellular region] [Homo sapiens]
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No pathways have been reviewed or authored by UniProt:Q99538 LGMN (58529)