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Details on Person UniProt:O75610 LEFTY1
| Class:Id | ReferenceGeneProduct:58525 |
|---|---|
| _chainChangeLog | signal peptide:1-21 added on Fri February 6 2015;propeptide:22-76 added on Fri February 6 2015;chain:77-366 added on Fri February 6 2015 |
| _displayName | UniProt:O75610 LEFTY1 |
| _timestamp | 2024-08-09 19:02:46 |
| chain | signal peptide:1-21 propeptide:22-76 chain:77-366 |
| checksum | BCF900C71ED9AA2A |
| comment | FUNCTION Required for left-right axis determination as a regulator of LEFTY2 and NODAL.SUBCELLULAR LOCATION The processing of the protein may also occur at the second R-X-X-R site located at AA 132-135. Processing appears to be regulated in a cell-type specific manner.SIMILARITY Belongs to the TGF-beta family. |
| description | recommendedName: Left-right determination factor 1 alternativeName: Left-right determination factor B alternativeName: Protein lefty-1 alternativeName: Protein lefty-B |
| geneName | LEFTY1 LEFTB LEFTYB UNQ278/PRO317 |
| identifier | O75610 |
| isSequenceChanged | FALSE |
| keyword | Cytokine Developmental protein Disulfide bond Glycoprotein Growth factor Proteomics identification Reference proteome Secreted Signal |
| modified | [InstanceEdit:9836292] Weiser, Joel, 2023-05-25 [InstanceEdit:9852000] Weiser, Joel, 2023-11-03 [InstanceEdit:9917590] Weiser, Joel, 2024-08-09 |
| name | LEFTY1 |
| referenceDatabase | [ReferenceDatabase:2] UniProt |
| referenceGene | [ReferenceDNASequence:8989037] ENSEMBL:ENSG00000243709 LEFTY1 [Homo sapiens] |
| secondaryIdentifier | LFTY1_HUMAN B2R7U0 Q53H67 Q5TE94 |
| sequenceLength | 366 |
| species | [Species:48887] Homo sapiens |
| (referenceEntity) | [EntityWithAccessionedSequence:1181326] LEFTY1 [extracellular region] [Homo sapiens] |
| [Change default viewing format] | |
No pathways have been reviewed or authored by UniProt:O75610 LEFTY1 (58525)
