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Details on Person UniProt:Q9UJU2 LEF1

Class:Id	ReferenceGeneProduct:58487
_chainChangeLog	chain:1-399 added on Sat February 7 2015
_displayName	UniProt:Q9UJU2 LEF1
_timestamp	2026-02-20 21:40:57
chain	chain:1-399
checksum	D480D440698EEFE3
comment	FUNCTION Transcription factor that binds DNA in a sequence-specific manner (PubMed:2010090). Participates in the Wnt signaling pathway (By similarity). Activates transcription of target genes in the presence of CTNNB1 and EP300 (By similarity). PIAG antagonizes both Wnt-dependent and Wnt-independent activation by LEF1 (By similarity). TLE1, TLE2, TLE3 and TLE4 repress transactivation mediated by LEF1 and CTNNB1 (PubMed:11266540). Regulates T-cell receptor alpha enhancer function (PubMed:19653274). Required for IL17A expressing gamma-delta T-cell maturation and development, via binding to regulator loci of BLK to modulate expression (By similarity). Acts as a positive regulator of odontoblast differentiation during mesenchymal tooth germ formation, expression is repressed during the bell stage by MSX1-mediated inhibition of CTNNB1 signaling (By similarity). May play a role in hair cell differentiation and follicle morphogenesis (By similarity).FUNCTION Transcriptionally activates MYC and CCND1 expression and enhances proliferation of pancreatic tumor cells.FUNCTION Lacks the CTNNB1 interaction domain and may therefore be an antagonist for Wnt signaling.FUNCTION Transcriptionally activates the fibronectin promoter, binds to and represses transcription from the E-cadherin promoter in a CTNNB1-independent manner, and is involved in reducing cellular aggregation and increasing cell migration of pancreatic cancer cells.SUBUNIT Binds the armadillo repeat of CTNNB1 and forms a stable complex. Interacts with EP300, TLE1 and PIASG (By similarity). Binds ALYREF/THOC4, MDFI and MDFIC. Interacts with NLK. Interacts with DAZAP2 (PubMed:19304756).INTERACTION Found in nuclear bodies upon PIASG binding.ALTERNATIVE PRODUCTS Additional isoforms seem to exist.TISSUE SPECIFICITY Detected in thymus. Not detected in normal colon, but highly expressed in colon cancer biopsies and colon cancer cell lines. Expressed in several pancreatic tumors and weakly expressed in normal pancreatic tissue. Isoforms 1 and 5 are detected in several pancreatic cell lines.DOMAIN Proline-rich and acidic regions are implicated in the activation functions of RNA polymerase II transcription factors.PTM Phosphorylated at Thr-155 and/or Ser-166 by NLK. Phosphorylation by NLK at these sites represses LEF1-mediated transcriptional activation of target genes of the canonical Wnt signaling pathway.DISEASE The disease is caused by variants affecting the gene represented in this entry.MISCELLANEOUS Produced by alternative promoter usage.MISCELLANEOUS Produced by alternative splicing of isoform 1. May be produced at very low levels due to a premature stop codon in the mRNA, leading to nonsense-mediated mRNA decay.MISCELLANEOUS Produced by alternative promoter usage. Acts as a dominant negative mutant.MISCELLANEOUS Produced by alternative splicing of isoform 3.MISCELLANEOUS Produced by alternative splicing of isoform 1.MISCELLANEOUS Produced by alternative splicing of isoform 1.SIMILARITY Belongs to the TCF/LEF family.
description	recommendedName: fullName evidence="25"Lymphoid enhancer-binding factor 1 shortName evidence="18"LEF-1 alternativeName: T cell-specific transcription factor 1-alpha shortName evidence="25"TCF1-alpha
geneName	LEF1
identifier	Q9UJU2
isSequenceChanged	FALSE
keyword	Activator Alternative promoter usage Alternative splicing Direct protein sequencing Disease variant DNA-binding Ectodermal dysplasia Isopeptide bond Nucleus Phosphoprotein Proteomics identification Reference proteome Transcription Transcription regulation Ubl conjugation Wnt signaling pathway
modified	[InstanceEdit:9836292] Weiser, Joel, 2023-05-25 [InstanceEdit:9852000] Weiser, Joel, 2023-11-03 [InstanceEdit:9862192] Weiser, Joel, 2024-02-26 [InstanceEdit:9926675] Weiser, Joel, 2024-11-03 [InstanceEdit:9983091] Weiser, Joel, 2026-02-20
name	LEF1
referenceDatabase	[ReferenceDatabase:2] UniProt
referenceGene	[ReferenceDNASequence:8996681] ENSEMBL:ENSG00000138795 LEF1 [Homo sapiens]
secondaryIdentifier	LEF1_HUMAN B4DG38 B7Z8E2 E9PDK3 Q3ZCU4 Q9HAZ0
sequenceLength	399
species	[Species:48887] Homo sapiens
(isoformParent)	[ReferenceIsoform:149598] UniProt:Q9UJU2-2 LEF1 [Homo sapiens] [ReferenceIsoform:149599] UniProt:Q9UJU2-3 LEF1 [Homo sapiens] [ReferenceIsoform:149600] UniProt:Q9UJU2-4 LEF1 [Homo sapiens] [ReferenceIsoform:415421] UniProt:Q9UJU2-1 LEF1 [Homo sapiens] [ReferenceIsoform:8975192] UniProt:Q9UJU2-5 LEF1 [Homo sapiens] [ReferenceIsoform:8975193] UniProt:Q9UJU2-6 LEF1 [Homo sapiens] [ReferenceIsoform:8975194] UniProt:Q9UJU2-7 LEF1 [Homo sapiens]
(referenceEntity)	[EntityWithAccessionedSequence:3214972] LEF1 [nucleoplasm] [Homo sapiens] [EntityWithAccessionedSequence:3214975] polySUMO2-K27,K269-LEF1 [nucleoplasm] [Homo sapiens] [EntityWithAccessionedSequence:4411389] pT155,S166-LEF1 [nucleoplasm] [Homo sapiens] [EntityWithAccessionedSequence:5368477] polySUMO2-K25,K267-LEF1 [nucleoplasm] [Homo sapiens]
(referenceSequence)	[GroupModifiedResidue:3214934] sumoylated lysine (polySUMO2 [nucleoplasm]) at 27 [GroupModifiedResidue:3214971] sumoylated lysine (polySUMO2 [nucleoplasm]) at 269 [ModifiedResidue:4411369] O-phospho-L-threonine at 155 [ModifiedResidue:4411385] O-phospho-L-serine at 166 [GroupModifiedResidue:5368473] sumoylated lysine (polySUMO2 [nucleoplasm]) at 25 [GroupModifiedResidue:5368478] sumoylated lysine (polySUMO2 [nucleoplasm]) at 267
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No pathways have been reviewed or authored by UniProt:Q9UJU2 LEF1 (58487)