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Details on Person UniProt:P07195 LDHB
| Class:Id | ReferenceGeneProduct:58469 |
|---|---|
| _chainChangeLog | initiator methionine:1 added on Fri February 6 2015;chain:2-334 added on Fri February 6 2015;initiator methionine:1 for 58469 removed on Fri Nov 03 2023;initiator methionine: for 58469 added on Fri Nov 03 2023;initiator methionine: for 58469 removed on Fri Aug 15 2025;initiator methionine:1 for 58469 added on Fri Aug 15 2025 |
| _displayName | UniProt:P07195 LDHB |
| _timestamp | 2025-08-15 21:16:19 |
| chain | initiator methionine:1 chain:2-334 |
| checksum | 3AD605DEED0D54A2 |
| comment | FUNCTION Interconverts simultaneously and stereospecifically pyruvate and lactate with concomitant interconversion of NADH and NAD(+).CATALYTIC ACTIVITY (S)-lactate + NAD(+) = pyruvate + NADH + H(+)PATHWAY Fermentation; pyruvate fermentation to lactate; (S)-lactate from pyruvate: step 1/1.SUBUNIT Homotetramer (PubMed:11276087). Interacts with PTEN upstream reading frame protein MP31; the interaction leads to inhibition of mitochondrial lactate dehydrogenase activity, preventing conversion of lactate to pyruvate in mitochondria (PubMed:33406399).INTERACTION Predominantly expressed in aerobic tissues such as cardiac muscle.DISEASE The disease is caused by variants affecting the gene represented in this entry.SIMILARITY Belongs to the LDH/MDH superfamily. LDH family.ONLINE INFORMATION Lactate dehydrogenase entryONLINE INFORMATION Another dark horse - Issue 109 of September 2009 |
| description | recommendedName: L-lactate dehydrogenase B chain shortName: LDH-B ecNumber evidence="4 8"1.1.1.27 alternativeName: LDH heart subunit shortName evidence="16"LDH-H alternativeName: Renal carcinoma antigen NY-REN-46 |
| geneName | LDHB |
| identifier | P07195 |
| isSequenceChanged | FALSE |
| keyword | 3D-structure Acetylation Cytoplasm Direct protein sequencing Disease variant Membrane Mitochondrion Mitochondrion inner membrane NAD Oxidoreductase Phosphoprotein Proteomics identification Reference proteome |
| modified | [InstanceEdit:9836292] Weiser, Joel, 2023-05-25 [InstanceEdit:9852000] Weiser, Joel, 2023-11-03 [InstanceEdit:9909836] Weiser, Joel, 2024-05-14 [InstanceEdit:9926675] Weiser, Joel, 2024-11-03 [InstanceEdit:9939033] Weiser, Joel, 2025-02-21 [InstanceEdit:9963647] Weiser, Joel, 2025-08-15 |
| name | LDHB |
| referenceDatabase | [ReferenceDatabase:2] UniProt |
| referenceGene | [ReferenceDNASequence:8957943] ENSEMBL:ENSG00000111716 LDHB [Homo sapiens] |
| secondaryIdentifier | LDHB_HUMAN |
| sequenceLength | 334 |
| species | [Species:48887] Homo sapiens |
| (referenceEntity) | [EntityWithAccessionedSequence:70503] LDHB [cytosol] [Homo sapiens] [EntityWithAccessionedSequence:8958228] LDHB [extracellular region] [Homo sapiens] |
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No pathways have been reviewed or authored by UniProt:P07195 LDHB (58469)
