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Details on Person UniProt:P00338 LDHA
Class:Id
ReferenceGeneProduct:58467
_chainChangeLog
initiator methionine:1 added on Sat February 7 2015;chain:2-332 added on Sat February 7 2015;initiator methionine:1 for 58467 removed on Fri Nov 03 2023;initiator methionine: for 58467 added on Fri Nov 03 2023;initiator methionine: for 58467 removed on Fri Aug 15 2025;initiator methionine:1 for 58467 added on Fri Aug 15 2025
_displayName
UniProt:P00338 LDHA
_timestamp
2025-08-15 21:53:55
chain
initiator methionine:1 chain:2-332
checksum
401E8604CEB7F908
comment
FUNCTION Interconverts simultaneously and stereospecifically pyruvate and lactate with concomitant interconversion of NADH and NAD(+).CATALYTIC ACTIVITY (S)-lactate + NAD(+) = pyruvate + NADH + H(+)ACTIVITY REGULATION Fermentation of pyruvate to lactate is inhibited when bound to folliculin FLCN, perhaps partly by FLCN preventing binding of cofactor NADH (PubMed:34381247).PATHWAY Fermentation; pyruvate fermentation to lactate; (S)-lactate from pyruvate: step 1/1.SUBUNIT Homotetramer (PubMed:11276087). Interacts with PTEN upstream reading frame protein MP31 (PubMed:33406399). Interacts with folliculin FLCN; the interaction is direct and inhibits enzymatic activity (PubMed:34381247).INTERACTION Predominantly expressed in anaerobic tissues such as skeletal muscle and liver.PTM ISGylated.DISEASE The disease is caused by variants affecting the gene represented in this entry.SIMILARITY Belongs to the LDH/MDH superfamily. LDH family.ONLINE INFORMATION Lactate dehydrogenase entryONLINE INFORMATION Another dark horse - Issue 109 of September 2009
3D-structure Acetylation Alternative splicing Cytoplasm Direct protein sequencing Disease variant Glycogen storage disease Isopeptide bond NAD Oxidoreductase Phosphoprotein Proteomics identification Reference proteome Ubl conjugation
