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Details on Person UniProt:Q13094 LCP2
| Class:Id | ReferenceGeneProduct:58463 |
|---|---|
| _chainChangeLog | chain:1-533 added on Fri February 6 2015 |
| _displayName | UniProt:Q13094 LCP2 |
| _timestamp | 2025-05-21 21:30:58 |
| chain | chain:1-533 |
| checksum | C5D22F31D36200C8 |
| comment | FUNCTION Adapter protein primarily involved in signaling pathways within T-cells, as well as other immune cells such as platelets, mast cells, and natural killer (NK) cells (PubMed:11313406, PubMed:33159816). Plays a crucial role for transducing signal from the T-cell receptor (TCR) after antigen recognition leading to T-cell activation. Mechanistically, once phosphorylated by the kinase ZAP70, mediates interactions with the guanine-nucleotide exchange factor VAV1, the adapter protein NCK and the kinase ITK (PubMed:8673706, PubMed:8702662). In turn, stimulates the activation of PKC-theta/PRKCQ and NF-kappa-B transcriptional activity in response to CD3 and CD28 costimulation (PubMed:11313406). Also plays an essential role in AGER-induced signaling pathways including p38 MAPK and ERK1/2 activation leading to cytokine release and pro-inflammatory responses (PubMed:33436632).SUBUNIT Interacts with SLA. Interacts with CBLB (By similarity). Interacts with GRB2 (PubMed:7706237). Interacts with SHB (PubMed:12084069). Interacts with PRAM1 (PubMed:11301322). Interacts (via SH2 domain) with CD6 (via tyrosine phosphorylated C-terminus) (PubMed:16914752, PubMed:24584089). Interacts with FYB1 and the phosphorylated form of FYB2 (PubMed:27335501). Interacts with 14-3-3 adapter/YWHAZ; this phosphorylation leads to YWHAZ proteolytic degradation (PubMed:33159816). Interacts with VAV1; this interaction plays a role in TCR-mediated cytokine production (PubMed:15144186). Interacts with AGER; this interaction plays an important role in AGER-mediated pro-inflammatory responses and cytokine release (PubMed:33436632).INTERACTION Highly expressed in spleen, thymus and peripheral blood leukocytes. Highly expressed also in T-cell and monocytic cell lines, expressed at lower level in B-cell lines. Not detected in fibroblast or neuroblastoma cell lines.DOMAIN The SH2 domain mediates interaction with phosphorylated CD6 (PubMed:16914752). The SH2 domain mediates interaction with SHB (PubMed:12084069).DOMAIN Possesses an N-terminal acidic domain containing three tyrosine phosphorylation motifs, a central proline-rich region, and a C-terminal SH2 domain.PTM Phosphorylated after T-cell receptor activation by ZAP70, ITK and TXK, which leads to the up-regulation of Th1 preferred cytokine IL-2. SYK-dependent phosphorylation is required for recruitment of PI3K signaling components.DISEASE The disease is caused by variants affecting the gene represented in this entry. |
| description | recommendedName: Lymphocyte cytosolic protein 2 alternativeName: SH2 domain-containing leukocyte protein of 76 kDa alternativeName: SLP-76 tyrosine phosphoprotein shortName: SLP76 |
| geneName | LCP2 |
| identifier | Q13094 |
| isSequenceChanged | FALSE |
| keyword | 3D-structure Cytoplasm Direct protein sequencing Phosphoprotein Proteomics identification Reference proteome SH2 domain |
| modified | [InstanceEdit:9836292] Weiser, Joel, 2023-05-25 [InstanceEdit:9852000] Weiser, Joel, 2023-11-03 [InstanceEdit:9926675] Weiser, Joel, 2024-11-03 [InstanceEdit:9939033] Weiser, Joel, 2025-02-21 [InstanceEdit:9948485] Weiser, Joel, 2025-05-21 |
| name | LCP2 |
| referenceDatabase | [ReferenceDatabase:2] UniProt |
| referenceGene | [ReferenceDNASequence:8993715] ENSEMBL:ENSG00000043462 LCP2 [Homo sapiens] |
| secondaryIdentifier | LCP2_HUMAN A8KA25 Q53XV4 |
| sequenceLength | 533 |
| species | [Species:48887] Homo sapiens |
| (referenceEntity) | [EntityWithAccessionedSequence:202175] p-Y113,128,145-LCP2 [cytosol] [Homo sapiens] [EntityWithAccessionedSequence:202306] LCP2 [cytosol] [Homo sapiens] [EntityWithAccessionedSequence:430149] p-Y113,Y128,Y145-LCP2 [plasma membrane] [Homo sapiens] |
| (referenceSequence) | [ModifiedResidue:202342] O4'-phospho-L-tyrosine at 113 [ModifiedResidue:202382] O4'-phospho-L-tyrosine at 145 [ModifiedResidue:202399] O4'-phospho-L-tyrosine at 128 |
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No pathways have been reviewed or authored by UniProt:Q13094 LCP2 (58463)
