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Details on Person UniProt:P18428 LBP
| Class:Id | ReferenceGeneProduct:58427 |
|---|---|
| _chainChangeLog | signal peptide:1-25 added on Fri February 6 2015;chain:26-481 added on Fri February 6 2015 |
| _displayName | UniProt:P18428 LBP |
| _timestamp | 2024-11-03 20:15:05 |
| chain | signal peptide:1-25 chain:26-481 |
| checksum | 5A0E4B9E5E604C72 |
| comment | FUNCTION Plays a role in the innate immune response. Binds to the lipid A moiety of bacterial lipopolysaccharides (LPS), a glycolipid present in the outer membrane of all Gram-negative bacteria (PubMed:24120359, PubMed:7517398). Acts as an affinity enhancer for CD14, facilitating its association with LPS. Promotes the release of cytokines in response to bacterial lipopolysaccharide (PubMed:24120359, PubMed:7517398).SUBUNIT When bound to LPS, interacts (via C-terminus) with soluble and membrane-bound CD14.INTERACTION Membrane-associated in polymorphonuclear Leukocytes (PMN) granules.TISSUE SPECIFICITY Detected in blood serum (at protein level).SIMILARITY Belongs to the BPI/LBP/Plunc superfamily. BPI/LBP family. |
| description | recommendedName: Lipopolysaccharide-binding protein shortName: LBP |
| geneName | LBP |
| identifier | P18428 |
| isSequenceChanged | FALSE |
| keyword | Antibiotic Antimicrobial Direct protein sequencing Disulfide bond Glycoprotein Immunity Innate immunity Lipid transport Membrane Proteomics identification Reference proteome Secreted Signal Transport |
| modified | [InstanceEdit:9836292] Weiser, Joel, 2023-05-25 [InstanceEdit:9852000] Weiser, Joel, 2023-11-03 [InstanceEdit:9917590] Weiser, Joel, 2024-08-09 [InstanceEdit:9926675] Weiser, Joel, 2024-11-03 |
| name | LBP |
| referenceDatabase | [ReferenceDatabase:2] UniProt |
| referenceGene | [ReferenceDNASequence:6790039] ENSEMBL:ENSG00000129988 LBP [Homo sapiens] |
| secondaryIdentifier | LBP_HUMAN B2R938 O43438 Q92672 Q9H403 Q9UD66 |
| sequenceLength | 481 |
| species | [Species:48887] Homo sapiens |
| (referenceEntity) | [EntityWithAccessionedSequence:166010] LBP [extracellular region] [Homo sapiens] |
| [Change default viewing format] | |
No pathways have been reviewed or authored by UniProt:P18428 LBP (58427)
