Query author contributions in Reactome
Reactome depends on collaboration between our curation team and outside experts to assemble and peer-review its pathway modules. The integration of ORCID within Reactome enables us to meet a key challenge with authoring, curating and reviewing biological information by incentivizing and crediting the external experts that contribute their expertise and time to the Reactome curation process. More information is available at ORCID and Reactome.
If you have an ORCID ID that is not listed on this page, please forward this information to us and we will update your Reactome pathway records.
Details on Person UniProt:O43561 LAT
| Class:Id | ReferenceGeneProduct:58417 |
|---|---|
| _chainChangeLog | chain:1-262 added on Fri February 6 2015 |
| _displayName | UniProt:O43561 LAT |
| _timestamp | 2024-11-03 20:01:36 |
| chain | chain:1-262 |
| checksum | BCD80AE7DCA64153 |
| comment | FUNCTION Required for TCR (T-cell antigen receptor)- and pre-TCR-mediated signaling, both in mature T-cells and during their development (PubMed:23514740, PubMed:25907557). Involved in FCGR3 (low affinity immunoglobulin gamma Fc region receptor III)-mediated signaling in natural killer cells and FCER1 (high affinity immunoglobulin epsilon receptor)-mediated signaling in mast cells. Couples activation of these receptors and their associated kinases with distal intracellular events such as mobilization of intracellular calcium stores, PKC activation, MAPK activation or cytoskeletal reorganization through the recruitment of PLCG1, GRB2, GRAP2, and other signaling molecules.SUBUNIT When phosphorylated, interacts directly with the PIK3R1 subunit of phosphoinositide 3-kinase and the SH2 domains of GRB2, GRAP, GRAP2, PLCG1 and PLCG2. Interacts indirectly with CBL, SOS, VAV, and LCP2. Interacts with SHB, SKAP2 and CLNK (By similarity). Interacts with FCGR1A. Interacts with GRB2, PLCG1 and THEMIS upon TCR activation in thymocytes (By similarity). Interacts with THEMIS2 (By similarity).SUBUNIT (Microbial infection) Interacts with herpes virus 1/HHV-1 protein US3; this interaction prevents the interaction between LAT and TRAF6.INTERACTION Present in lipid rafts.ALTERNATIVE PRODUCTS Expressed in thymus, T-cells, NK cells, mast cells and, at lower levels, in spleen. Present in T-cells but not B-cells (at protein level).PTM Phosphorylated on tyrosines by ZAP70 upon TCR activation, or by SYK upon other immunoreceptor activation; which leads to the recruitment of multiple signaling molecules. Is one of the most prominently tyrosine-phosphorylated proteins detected following TCR engagement. May be dephosphorylated by PTPRJ. Phosphorylated by ITK leading to the recruitment of VAV1 to LAT-containing complexes.PTM Palmitoylation of Cys-26 and Cys-29 is required for raft targeting and efficient phosphorylation.PTM 'Lys-63'-linked ubiquitinated by TRAF6.DISEASE The disease is caused by variants affecting the gene represented in this entry.MISCELLANEOUS Engagement of killer inhibitory receptors (KIR) disrupts the interaction of PLCG1 with LAT and blocks target cell-induced activation of PLC, maybe by inducing the dephosphorylation of LAT. |
| description | recommendedName: Linker for activation of T-cells family member 1 alternativeName: 36 kDa phosphotyrosine adapter protein shortName: pp36 alternativeName: p36-38 |
| geneName | LAT |
| identifier | O43561 |
| isSequenceChanged | FALSE |
| keyword | Adaptive immunity Alternative splicing Cell membrane Direct protein sequencing Immunity Lipoprotein Mast cell degranulation Membrane Palmitate Phosphoprotein Proteomics identification Reference proteome Signal-anchor Transmembrane Transmembrane helix Ubl conjugation |
| modified | [InstanceEdit:9836292] Weiser, Joel, 2023-05-25 [InstanceEdit:9852000] Weiser, Joel, 2023-11-03 [InstanceEdit:9917590] Weiser, Joel, 2024-08-09 [InstanceEdit:9926675] Weiser, Joel, 2024-11-03 |
| name | LAT |
| referenceDatabase | [ReferenceDatabase:2] UniProt |
| referenceGene | [ReferenceDNASequence:9003618] ENSEMBL:ENSG00000213658 LAT [Homo sapiens] |
| secondaryIdentifier | LAT_HUMAN B7WPI0 C7C5T6 G5E9K3 O43919 |
| sequenceLength | 262 |
| species | [Species:48887] Homo sapiens |
| (isoformParent) | [ReferenceIsoform:149573] UniProt:O43561-2 LAT [Homo sapiens] [ReferenceIsoform:401540] UniProt:O43561-1 LAT [Homo sapiens] [ReferenceIsoform:8969729] UniProt:O43561-3 LAT [Homo sapiens] [ReferenceIsoform:8969730] UniProt:O43561-4 LAT [Homo sapiens] [ReferenceIsoform:8969731] UniProt:O43561-5 LAT [Homo sapiens] |
| (referenceEntity) | [EntityWithAccessionedSequence:202322] LAT [plasma membrane] [Homo sapiens] [EntityWithAccessionedSequence:202364] p-5Y-LAT [plasma membrane] [Homo sapiens] [EntityWithAccessionedSequence:434829] p-Y200,Y220-LAT [plasma membrane] [Homo sapiens] |
| (referenceSequence) | [ModifiedResidue:202242] O4'-phospho-L-tyrosine at 161 [ModifiedResidue:202286] O4'-phospho-L-tyrosine at 255 [ModifiedResidue:202351] O4'-phospho-L-tyrosine at 220 [ModifiedResidue:202363] O4'-phospho-L-tyrosine at 200 [ModifiedResidue:2396546] O4'-phospho-L-tyrosine at 156 |
| [Change default viewing format] | |
No pathways have been reviewed or authored by UniProt:O43561 LAT (58417)
