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Details on Person UniProt:P01615 IGKV2D-28
| Class:Id | ReferenceGeneProduct:58329 |
|---|---|
| _chainChangeLog | chain:1- added on Fri February 6 2015;chain:1- removed on Fri November 4 2016;signal peptide:1-19 added on Fri November 4 2016;chain:20-120 added on Fri November 4 2016 |
| _displayName | UniProt:P01615 IGKV2D-28 |
| _timestamp | 2024-08-09 19:22:20 |
| chain | signal peptide:1-19 chain:20-120 |
| checksum | 0B78BEF46FFB1F97 |
| comment | FUNCTION V region of the variable domain of immunoglobulin light chains that participates in the antigen recognition (PubMed:24600447). Immunoglobulins, also known as antibodies, are membrane-bound or secreted glycoproteins produced by B lymphocytes. In the recognition phase of humoral immunity, the membrane-bound immunoglobulins serve as receptors which, upon binding of a specific antigen, trigger the clonal expansion and differentiation of B lymphocytes into immunoglobulins-secreting plasma cells. Secreted immunoglobulins mediate the effector phase of humoral immunity, which results in the elimination of bound antigens (PubMed:20176268, PubMed:22158414). The antigen binding site is formed by the variable domain of one heavy chain, together with that of its associated light chain. Thus, each immunoglobulin has two antigen binding sites with remarkable affinity for a particular antigen. The variable domains are assembled by a process called V-(D)-J rearrangement and can then be subjected to somatic hypermutations which, after exposure to antigen and selection, allow affinity maturation for a particular antigen (PubMed:17576170, PubMed:20176268).SUBUNIT Immunoglobulins are composed of two identical heavy chains and two identical light chains; disulfide-linked.SUBCELLULAR LOCATION There are several alleles. The sequence shown is that of IMGT allele IGKV2D-28*01.CAUTION For an example of a full-length immunoglobulin kappa light chain see AC P0DOX7. |
| description | recommendedName: fullName evidence="7 12"Immunoglobulin kappa variable 2D-28 alternativeName: fullName evidence="17"Ig kappa chain V-II region FR alternativeName: fullName evidence="16"Ig kappa chain V-II region GM607 alternativeName: fullName evidence="18"Ig kappa chain V-II region MIL alternativeName: fullName evidence="14 15"Ig kappa chain V-II region TEW |
| geneName | IGKV2D-28 |
| identifier | P01615 |
| isSequenceChanged | FALSE |
| keyword | Adaptive immunity Cell membrane Direct protein sequencing Disulfide bond Immunity Immunoglobulin Immunoglobulin domain Membrane Reference proteome Secreted Signal |
| modified | [InstanceEdit:9836292] Weiser, Joel, 2023-05-25 [InstanceEdit:9852000] Weiser, Joel, 2023-11-03 [InstanceEdit:9917590] Weiser, Joel, 2024-08-09 |
| name | IGKV2D-28 |
| referenceDatabase | [ReferenceDatabase:2] UniProt |
| referenceGene | [ReferenceDNASequence:8993713] ENSEMBL:ENSG00000242534 IGKV2D-28 [Homo sapiens] |
| secondaryIdentifier | KVD28_HUMAN A0A0A0MTQ6 P01616 P01617 P06309 |
| sequenceLength | 120 |
| species | [Species:48887] Homo sapiens |
| (referenceEntity) | [EntityWithAccessionedSequence:983595] Ig kappa chain V-II region FR [extracellular region] [Homo sapiens] [EntityWithAccessionedSequence:2038754] Ig kappa chain V-II region FR [plasma membrane] [Homo sapiens] |
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No pathways have been reviewed or authored by UniProt:P01615 IGKV2D-28 (58329)
