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Details on Person UniProt:P04432 IGKV1D-39

Class:Id	ReferenceGeneProduct:58323
_chainChangeLog	signal peptide:1-22 added on Fri February 6 2015;chain:23-129 added on Fri February 6 2015;chain:23-129 removed on Fri November 4 2016;chain:23-117 added on Fri November 4 2016
_displayName	UniProt:P04432 IGKV1D-39
_timestamp	2024-08-09 19:22:20
chain	signal peptide:1-22 chain:23-117
checksum	ED1DC5B0055AB9D4
comment	FUNCTION V region of the variable domain of immunoglobulin light chains that participates in the antigen recognition (PubMed:24600447). Immunoglobulins, also known as antibodies, are membrane-bound or secreted glycoproteins produced by B lymphocytes. In the recognition phase of humoral immunity, the membrane-bound immunoglobulins serve as receptors which, upon binding of a specific antigen, trigger the clonal expansion and differentiation of B lymphocytes into immunoglobulins-secreting plasma cells. Secreted immunoglobulins mediate the effector phase of humoral immunity, which results in the elimination of bound antigens (PubMed:20176268, PubMed:22158414). The antigen binding site is formed by the variable domain of one heavy chain, together with that of its associated light chain. Thus, each immunoglobulin has two antigen binding sites with remarkable affinity for a particular antigen. The variable domains are assembled by a process called V-(D)-J rearrangement and can then be subjected to somatic hypermutations which, after exposure to antigen and selection, allow affinity maturation for a particular antigen (PubMed:17576170, PubMed:20176268).SUBUNIT Immunoglobulins are composed of two identical heavy chains and two identical light chains; disulfide-linked.SUBCELLULAR LOCATION There are several alleles. The sequence shown is that of IMGT allele IGKV1D-39*01.CAUTION For an example of a full-length immunoglobulin kappa light chain see AC P0DOX7.SEQUENCE CAUTION Chimeric DNA. A chimeric DNA corresponding to regions V and J of immunoglobulin kappa light chain.
description	recommendedName: fullName evidence="4 9"Immunoglobulin kappa variable 1D-39 alternativeName: fullName evidence="11"Ig kappa chain V-I region Daudi
geneName	IGKV1D-39
identifier	P04432
isSequenceChanged	FALSE
keyword	Adaptive immunity Cell membrane Disulfide bond Immunity Immunoglobulin Immunoglobulin domain Membrane Reference proteome Secreted Signal
modified	[InstanceEdit:9836292] Weiser, Joel, 2023-05-25 [InstanceEdit:9852000] Weiser, Joel, 2023-11-03 [InstanceEdit:9917590] Weiser, Joel, 2024-08-09
name	IGKV1D-39
referenceDatabase	[ReferenceDatabase:2] UniProt
referenceGene	[ReferenceDNASequence:8992540] ENSEMBL:ENSG00000251546 IGKV1D-39 [Homo sapiens]
secondaryIdentifier	KVD39_HUMAN
sequenceLength	117
species	[Species:48887] Homo sapiens
(referenceEntity)	[EntityWithAccessionedSequence:983551] Ig kappa chain V-I region Daudi [extracellular region] [Homo sapiens] [EntityWithAccessionedSequence:2038768] Ig kappa chain V-I region Daudi [plasma membrane] [Homo sapiens]
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No pathways have been reviewed or authored by UniProt:P04432 IGKV1D-39 (58323)