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Details on Person UniProt:P23919 DTYMK
| Class:Id | ReferenceGeneProduct:58271 |
|---|---|
| _chainChangeLog | initiator methionine:1 added on Sat February 7 2015;chain:2-212 added on Sat February 7 2015;initiator methionine:1 for 58271 removed on Fri Nov 03 2023;initiator methionine: for 58271 added on Fri Nov 03 2023;initiator methionine: for 58271 removed on Fri Aug 15 2025;initiator methionine:1 for 58271 added on Fri Aug 15 2025 |
| _displayName | UniProt:P23919 DTYMK |
| _timestamp | 2025-08-15 21:08:20 |
| chain | initiator methionine:1 chain:2-212 |
| checksum | A52876625B3621B1 |
| comment | FUNCTION Catalyzes the phosphorylation of thymidine monophosphate (dTMP) to thymidine diphosphate (dTDP), the immediate precursor for the DNA building block dTTP, with ATP as the preferred phosphoryl donor in the presence of Mg(2+).CATALYTIC ACTIVITY dTMP + ATP = dTDP + ADPCOFACTOR Pyrimidine metabolism; dTTP biosynthesis.SUBUNIT Homodimer.ALTERNATIVE PRODUCTS The levels of dTMP kinase mRNA and its enzymatic activity fluctuate during the cell cycle, peaking at the S phase.DISEASE The disease is caused by variants affecting the gene represented in this entry.SIMILARITY Belongs to the thymidylate kinase family. |
| description | recommendedName: Thymidylate kinase ecNumber evidence="1 3 5 6 10"2.7.4.9 alternativeName: dTMP kinase |
| geneName | DTYMK CDC8 TMPK TYMK |
| identifier | P23919 |
| isSequenceChanged | FALSE |
| keyword | 3D-structure Acetylation Alternative splicing ATP-binding Disease variant Intellectual disability Kinase Neurodegeneration Nucleotide biosynthesis Nucleotide-binding Proteomics identification Reference proteome Transferase |
| modified | [InstanceEdit:9836292] Weiser, Joel, 2023-05-25 [InstanceEdit:9852000] Weiser, Joel, 2023-11-03 [InstanceEdit:9926675] Weiser, Joel, 2024-11-03 [InstanceEdit:9939033] Weiser, Joel, 2025-02-21 [InstanceEdit:9963647] Weiser, Joel, 2025-08-15 |
| name | DTYMK |
| referenceDatabase | [ReferenceDatabase:2] UniProt |
| referenceGene | [ReferenceDNASequence:8995507] ENSEMBL:ENSG00000168393 DTYMK [Homo sapiens] |
| secondaryIdentifier | KTHY_HUMAN B7ZW70 Q6FGX1 Q9BUX4 |
| sequenceLength | 212 |
| species | [Species:48887] Homo sapiens |
| (isoformParent) | [ReferenceIsoform:8976069] UniProt:P23919-1 DTYMK [Homo sapiens] [ReferenceIsoform:8976070] UniProt:P23919-2 DTYMK [Homo sapiens] |
| (referenceEntity) | [EntityWithAccessionedSequence:73496] DTYMK [cytosol] [Homo sapiens] |
| [Change default viewing format] | |
No pathways have been reviewed or authored by UniProt:P23919 DTYMK (58271)
