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Details on Person UniProt:P08922 ROS1

Class:IdReferenceGeneProduct:58259
_chainChangeLogsignal peptide:1-27 added on Fri February 6 2015;chain:28-2347 added on Fri February 6 2015
_displayNameUniProt:P08922 ROS1
_timestamp2025-05-21 21:20:57
chainsignal peptide:1-27
chain:28-2347
checksum98902B9A59ACB8F5
commentFUNCTION Receptor tyrosine kinase (RTK) that plays a role in epithelial cell differentiation and regionalization of the proximal epididymal epithelium. NELL2 is an endogenous ligand for ROS1. Upon endogenous stimulation by NELL2, ROS1 activates the intracellular signaling pathway and triggers epididymal epithelial differentiation and subsequent sperm maturation (By similarity). May activate several downstream signaling pathways related to cell differentiation, proliferation, growth and survival including the PI3 kinase-mTOR signaling pathway. Mediates the phosphorylation of PTPN11, an activator of this pathway. May also phosphorylate and activate the transcription factor STAT3 to control anchorage-independent cell growth. Mediates the phosphorylation and the activation of VAV3, a guanine nucleotide exchange factor regulating cell morphology. May activate other downstream signaling proteins including AKT1, MAPK1, MAPK3, IRS1 and PLCG2.CATALYTIC ACTIVITY L-tyrosyl-[protein] + ATP = O-phospho-L-tyrosyl-[protein] + ADP + H(+)ACTIVITY REGULATION Inhibited by dephosphorylation by PTPN6.SUBUNIT Interacts with PTPN6 (via SH2 1 domain); the interaction is direct and promotes ROS1 dephosphorylation (By similarity). Interacts with PTPN11; may activate the PI3 kinase-mTOR signaling pathway (PubMed:16885344). Interacts with VAV3; constitutive interaction mediating VAV3 phosphorylation (PubMed:11094073).INTERACTION Expressed in brain. Expression is increased in primary gliomas.PTM Phosphorylated. Probably autophosphorylates. Phosphorylation at Tyr-2274 is required for the interaction with PTPN6 that mediates ROS1 dephosphorylation. Phosphorylation at Tyr-2274 stimulates the kinase activity and the activation of the ERK1 signaling cascade (By similarity). Phosphorylation at Tyr-2274 and/or Tyr-2334 recruits PTPN11 (PubMed:12538861).DISEASE A chromosomal aberration involving ROS1 is found in a glioblastoma multiforme sample. An intra-chromosomal deletion del(6)(q21q21) is responsible for the formation of GOPC-ROS1 chimeric protein which is localized to the Golgi and has a constitutive receptor tyrosine kinase activity. A SLC34A2-ROS1 chimeric protein produced in non-small cell lung cancer cells also retains a constitutive kinase activity. A third type of chimeric protein CD74-ROS1 was also identified in those cells.SIMILARITY Belongs to the protein kinase superfamily. Tyr protein kinase family. Insulin receptor subfamily.
descriptionrecommendedName: Proto-oncogene tyrosine-protein kinase ROS ecNumber evidence="7 10"2.7.10.1 alternativeName: Proto-oncogene c-Ros alternativeName: Proto-oncogene c-Ros-1 alternativeName: Receptor tyrosine kinase c-ros oncogene 1 alternativeName: c-Ros receptor tyrosine kinase
geneNameROS1
MCF3
ROS
identifierP08922
isSequenceChangedFALSE
keyword3D-structure
ATP-binding
Cell membrane
Chromosomal rearrangement
Glycoprotein
Kinase
Membrane
Nucleotide-binding
Phosphoprotein
Proteomics identification
Proto-oncogene
Receptor
Reference proteome
Repeat
Signal
Transferase
Transmembrane
Transmembrane helix
Tyrosine-protein kinase
modified[InstanceEdit:9836292] Weiser, Joel, 2023-05-25
[InstanceEdit:9852000] Weiser, Joel, 2023-11-03
[InstanceEdit:9862192] Weiser, Joel, 2024-02-26
[InstanceEdit:9926675] Weiser, Joel, 2024-11-03
[InstanceEdit:9939033] Weiser, Joel, 2025-02-21
[InstanceEdit:9948485] Weiser, Joel, 2025-05-21
nameROS1
referenceDatabase[ReferenceDatabase:2] UniProt
referenceGene[ReferenceDNASequence:9003209] ENSEMBL:ENSG00000047936 ROS1 [Homo sapiens]
secondaryIdentifierROS1_HUMAN
Q15368
Q5TDB5
sequenceLength2347
species[Species:48887] Homo sapiens
(referenceEntity)[EntityWithAccessionedSequence:211420] ROS1 [plasma membrane] [Homo sapiens]
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