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Details on Person UniProt:P21108 PRPS1L1
| Class:Id | ReferenceGeneProduct:58227 |
|---|---|
| _chainChangeLog | initiator methionine:1 added on Fri February 6 2015;chain:2-318 added on Fri February 6 2015;initiator methionine:1 for 58227 removed on Fri Nov 03 2023;initiator methionine: for 58227 added on Fri Nov 03 2023;initiator methionine: for 58227 removed on Fri Aug 15 2025;initiator methionine:1 for 58227 added on Fri Aug 15 2025 |
| _displayName | UniProt:P21108 PRPS1L1 |
| _timestamp | 2025-08-15 22:11:07 |
| chain | initiator methionine:1 chain:2-318 |
| checksum | 6A4EDC798FB3B296 |
| comment | FUNCTION Catalyzes the synthesis of phosphoribosylpyrophosphate (PRPP) that is essential for nucleotide synthesis.CATALYTIC ACTIVITY D-ribose 5-phosphate + ATP = 5-phospho-alpha-D-ribose 1-diphosphate + AMP + H(+)COFACTOR Activated by magnesium and inorganic phosphate.PATHWAY Metabolic intermediate biosynthesis; 5-phospho-alpha-D-ribose 1-diphosphate biosynthesis; 5-phospho-alpha-D-ribose 1-diphosphate from D-ribose 5-phosphate (route I): step 1/1.SUBUNIT Homodimer. The active form is probably a hexamer composed of 3 homodimers (By similarity).TISSUE SPECIFICITY Testis.SIMILARITY Belongs to the ribose-phosphate pyrophosphokinase family.CAUTION According to PubMed:2168892, this sequence initiates from a non-AUG codon; N-terminal ACG codon did serve as a start codon. |
| description | recommendedName: Ribose-phosphate pyrophosphokinase 3 ecNumber: 2.7.6.1 alternativeName: Phosphoribosyl pyrophosphate synthase 1-like 1 shortName: PRPS1-like 1 alternativeName: Phosphoribosyl pyrophosphate synthase III shortName: PRS-III |
| geneName | PRPS1L1 PRPS3 PRPSL |
| identifier | P21108 |
| isSequenceChanged | FALSE |
| keyword | ATP-binding Direct protein sequencing Kinase Magnesium Metal-binding Nucleotide biosynthesis Nucleotide-binding Proteomics identification Reference proteome Transferase |
| modified | [InstanceEdit:9836292] Weiser, Joel, 2023-05-25 [InstanceEdit:9852000] Weiser, Joel, 2023-11-03 [InstanceEdit:9926675] Weiser, Joel, 2024-11-03 [InstanceEdit:9939033] Weiser, Joel, 2025-02-21 [InstanceEdit:9963647] Weiser, Joel, 2025-08-15 |
| name | PRPS1L1 |
| referenceDatabase | [ReferenceDatabase:2] UniProt |
| referenceGene | [ReferenceDNASequence:9016018] ENSEMBL:ENSG00000229937 PRPS1L1 [Homo sapiens] |
| secondaryIdentifier | PRPS3_HUMAN Q6P5P6 |
| sequenceLength | 318 |
| species | [Species:48887] Homo sapiens |
| (referenceEntity) | [EntityWithAccessionedSequence:58226] PRPS1L1 [cytosol] [Homo sapiens] |
| [Change default viewing format] | |
No pathways have been reviewed or authored by UniProt:P21108 PRPS1L1 (58227)
