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Details on Person UniProt:P24723 PRKCH
| Class:Id | ReferenceGeneProduct:58209 |
|---|---|
| _chainChangeLog | chain:1-683 added on Fri February 6 2015 |
| _displayName | UniProt:P24723 PRKCH |
| _timestamp | 2025-02-21 19:49:20 |
| chain | chain:1-683 |
| checksum | 0A29806CE31912F2 |
| comment | FUNCTION Calcium-independent, phospholipid- and diacylglycerol (DAG)-dependent serine/threonine-protein kinase that is involved in the regulation of cell differentiation in keratinocytes and pre-B cell receptor, mediates regulation of epithelial tight junction integrity and foam cell formation, and is required for glioblastoma proliferation and apoptosis prevention in MCF-7 cells. In keratinocytes, binds and activates the tyrosine kinase FYN, which in turn blocks epidermal growth factor receptor (EGFR) signaling and leads to keratinocyte growth arrest and differentiation. Associates with the cyclin CCNE1-CDK2-CDKN1B complex and inhibits CDK2 kinase activity, leading to RB1 dephosphorylation and thereby G1 arrest in keratinocytes. In association with RALA activates actin depolymerization, which is necessary for keratinocyte differentiation. In the pre-B cell receptor signaling, functions downstream of BLNK by up-regulating IRF4, which in turn activates L chain gene rearrangement. Regulates epithelial tight junctions (TJs) by phosphorylating occludin (OCLN) on threonine residues, which is necessary for the assembly and maintenance of TJs. In association with PLD2 and via TLR4 signaling, is involved in lipopolysaccharide (LPS)-induced RGS2 down-regulation and foam cell formation. Upon PMA stimulation, mediates glioblastoma cell proliferation by activating the mTOR pathway, the PI3K/AKT pathway and the ERK1-dependent phosphorylation of ELK1. Involved in the protection of glioblastoma cells from irradiation-induced apoptosis by preventing caspase-9 activation. In camptothecin-treated MCF-7 cells, regulates NF-kappa-B upstream signaling by activating IKBKB, and confers protection against DNA damage-induced apoptosis. Promotes oncogenic functions of ATF2 in the nucleus while blocking its apoptotic function at mitochondria. Phosphorylates ATF2 which promotes its nuclear retention and transcriptional activity and negatively regulates its mitochondrial localization.CATALYTIC ACTIVITY L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+)CATALYTIC ACTIVITY L-threonyl-[protein] + ATP = O-phospho-L-threonyl-[protein] + ADP + H(+)ACTIVITY REGULATION Novel PKCs (PRKCD, PRKCE, PRKCH and PRKCQ) are calcium-insensitive, but activated by diacylglycerol (DAG) and phosphatidylserine. Three specific sites; Thr-513 (activation loop of the kinase domain), Thr-656 (turn motif) and Ser-675 (hydrophobic region), need to be phosphorylated for its full activation. Inhibited by PRKCH upstream open reading frame 2 (PubMed:34593629).SUBUNIT Interacts with FYN (By similarity). Interacts with RALA (By similarity). Interacts with DGKQ (PubMed:15632189). Interacts with PRKCH upstream open reading frame 2; the interaction leads to inhibition of kinase activity (PubMed:34593629).INTERACTION Most abundant in lung, less in heart and skin.INDUCTION By stress conditions caused by amino acid starvation (at protein level).DOMAIN The C1 domain, containing the phorbol ester/DAG-type region 1 (C1A) and 2 (C1B), is the diacylglycerol sensor and the C2 domain is a non-calcium binding domain.DISEASE Disease susceptibility is associated with variants affecting the gene represented in this entry.SIMILARITY Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. PKC subfamily. |
| description | recommendedName: Protein kinase C eta type ecNumber evidence="24"2.7.11.13 alternativeName: PKC-L alternativeName: nPKC-eta |
| geneName | PRKCH PKCL PRKCL |
| identifier | P24723 |
| isSequenceChanged | FALSE |
| keyword | 3D-structure Alternative splicing ATP-binding Cytoplasm Differentiation Kinase Metal-binding Nucleotide-binding Phosphoprotein Proteomics identification Reference proteome Repeat Serine/threonine-protein kinase Transferase Zinc Zinc-finger |
| modified | [InstanceEdit:9836292] Weiser, Joel, 2023-05-25 [InstanceEdit:9852000] Weiser, Joel, 2023-11-03 [InstanceEdit:9926675] Weiser, Joel, 2024-11-03 [InstanceEdit:9939033] Weiser, Joel, 2025-02-21 |
| name | PRKCH |
| referenceDatabase | [ReferenceDatabase:2] UniProt |
| referenceGene | [ReferenceDNASequence:8993708] ENSEMBL:ENSG00000027075 PRKCH [Homo sapiens] |
| secondaryIdentifier | KPCL_HUMAN B4DJN5 Q16246 Q8NE03 |
| sequenceLength | 683 |
| species | [Species:48887] Homo sapiens |
| (isoformParent) | [ReferenceIsoform:8971988] UniProt:P24723-1 PRKCH [Homo sapiens] [ReferenceIsoform:8971989] UniProt:P24723-2 PRKCH [Homo sapiens] |
| (referenceEntity) | [EntityWithAccessionedSequence:58208] PRKCH [cytosol] [Homo sapiens] [EntityWithAccessionedSequence:9750060] p-PRKCH [cytosol] [Homo sapiens] |
| (referenceSequence) | [ModifiedResidue:9750049] O-phospho-L-serine at 32 [ModifiedResidue:9750052] O-phospho-L-serine at 28 [ModifiedResidue:9750073] L-serine residue at 28 |
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No pathways have been reviewed or authored by UniProt:P24723 PRKCH (58209)
