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Details on Person UniProt:P46020 PHKA1
| Class:Id | ReferenceGeneProduct:58187 |
|---|---|
| _chainChangeLog | chain:1-1223 added on Fri February 6 2015 |
| _displayName | UniProt:P46020 PHKA1 |
| _timestamp | 2024-11-03 19:46:38 |
| chain | chain:1-1223 |
| checksum | 48511719C0BFE40F |
| comment | FUNCTION Phosphorylase b kinase catalyzes the phosphorylation of serine in certain substrates, including troponin I. The alpha chain may bind calmodulin.ACTIVITY REGULATION By phosphorylation of various serine residues. Allosteric regulation by calcium.PATHWAY Glycan biosynthesis; glycogen metabolism.SUBUNIT Hexadecamer of 4 heterotetramers, each composed of alpha, beta, gamma, and delta subunits. Alpha (PHKA1 or PHKA2) and beta (PHKB) are regulatory subunits, gamma (PHKG1 or PHKG2) is the catalytic subunit, and delta is calmodulin.INTERACTION Muscle specific. Isoform 1 is predominant in vastus lateralis muscle. Isoform 2 predominates slightly in heart, and it predominates clearly in the other tissues tested.PTM Although the final Cys may be farnesylated, the terminal tripeptide is probably not removed, and the C-terminus is not methylated.DISEASE The disease is caused by variants affecting the gene represented in this entry.SIMILARITY Belongs to the phosphorylase b kinase regulatory chain family. |
| description | recommendedName: Phosphorylase b kinase regulatory subunit alpha, skeletal muscle isoform shortName: Phosphorylase kinase alpha M subunit |
| geneName | PHKA1 PHKA |
| identifier | P46020 |
| isSequenceChanged | FALSE |
| keyword | 3D-structure Alternative splicing Calmodulin-binding Carbohydrate metabolism Cell membrane Disease variant Glycogen metabolism Glycogen storage disease Lipoprotein Membrane Muscle protein Phosphoprotein Prenylation Proteomics identification Reference proteome |
| modified | [InstanceEdit:9836292] Weiser, Joel, 2023-05-25 [InstanceEdit:9852000] Weiser, Joel, 2023-11-03 [InstanceEdit:9917590] Weiser, Joel, 2024-08-09 [InstanceEdit:9926675] Weiser, Joel, 2024-11-03 |
| name | PHKA1 |
| referenceDatabase | [ReferenceDatabase:2] UniProt |
| referenceGene | [ReferenceDNASequence:8996669] ENSEMBL:ENSG00000067177 PHKA1 [Homo sapiens] |
| secondaryIdentifier | KPB1_HUMAN B7ZL05 B7ZL07 Q2M3D7 |
| sequenceLength | 1223 |
| species | [Species:48887] Homo sapiens |
| (isoformParent) | [ReferenceIsoform:149461] UniProt:P46020-2 PHKA1 [Homo sapiens] [ReferenceIsoform:404085] UniProt:P46020-1 PHKA1 [Homo sapiens] [ReferenceIsoform:8973839] UniProt:P46020-3 PHKA1 [Homo sapiens] |
| (referenceEntity) | [EntityWithAccessionedSequence:71516] PHKA1 [cytosol] [Homo sapiens] |
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No pathways have been reviewed or authored by UniProt:P46020 PHKA1 (58187)
