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Details on Person UniProt:P01042 KNG1

Class:Id	ReferenceGeneProduct:58181
_chainChangeLog	signal peptide:1-18 added on Sat February 7 2015;chain:19-644 added on Sat February 7 2015;chain:19-380 added on Sat February 7 2015;peptide:376-389 added on Sat February 7 2015;peptide:380-389 added on Sat February 7 2015;peptide:381-389 added on Sat February 7 2015;chain:390-644 added on Sat February 7 2015;peptide:431-434 added on Sat February 7 2015
_displayName	UniProt:P01042 KNG1
_timestamp	2025-05-21 21:50:09
chain	signal peptide:1-18 chain:19-644 chain:19-380 peptide:376-389 peptide:380-389 peptide:381-389 chain:390-644 peptide:431-434
checksum	3132B4DF2954C24E
comment	FUNCTION Kininogens are inhibitors of thiol proteases. HMW-kininogen plays an important role in blood coagulation by helping to position optimally prekallikrein and factor XI next to factor XII; HMW-kininogen inhibits the thrombin- and plasmin-induced aggregation of thrombocytes. LMW-kininogen inhibits the aggregation of thrombocytes. LMW-kininogen is in contrast to HMW-kininogen not involved in blood clotting.FUNCTION The active peptide bradykinin is a potent vasodilatator that is released from HMW-kininogen shows a variety of physiological effects: (A) influence in smooth muscle contraction, (B) induction of hypotension, (C) natriuresis and diuresis, (D) decrease in blood glucose level, (E) it is a mediator of inflammation and causes (E1) increase in vascular permeability, (E2) stimulation of nociceptors (4E3) release of other mediators of inflammation (e.g. prostaglandins), (F) it has a cardioprotective effect (directly via bradykinin action, indirectly via endothelium-derived relaxing factor action).SUBUNIT Interacts (high molecular weight kininogen) (via amino acids 402-532) with triafestin-1 and triafestin-2, anticoagulant proteins from Triatoma infestans (PubMed:17645545). Interacts (high molecular weight kininogen) (via amino acids 402-532) with short form salivary protein D7R1, an anticoagulant protein from Anopheles stephensi (PubMed:17645545). Interacts (high molecular weight kininogen) (via amino acids 421-466 and 459-513) with haemaphysalin, an anticoagulant protein from Haemaphysalis longicornis (PubMed:15711755, PubMed:16169873).INTERACTION Secreted in plasma. T-kinin is detected in malignant ovarian, colon and breast carcinomas, but not in benign tumors.PTM Bradykinin is inactivated by ACE, which removes the dipeptide Arg-Phe from its C-terminus.PTM Bradykinin is released from kininogen by plasma kallikrein.PTM Hydroxylation of Pro-383 occurs prior to the release of bradykinin.PTM Phosphorylated by FAM20C in the extracellular medium.PTM N- and O-glycosylated. O-glycosylated with core 1 or possibly core 8 glycans.PTM (Microbial infection) Bradykinin is generated upon proteolytic cleavage by S.pyogenes SpeB to produce hypotension during septic shock.POLYMORPHISM The T-kinin peptide is missing residues 378 to 380, probably as a result of a naturally occurring variant. The complete sequence of the T-kinin peptide is therefore ISRPPGFSPFR. This peptide is associated with malignant tumors but not with benign ones.DISEASE The disease is caused by variants affecting the gene represented in this entry.DISEASE The disease is caused by variants affecting the gene represented in this entry.ONLINE INFORMATION High molecular weight kininogen entry
description	recommendedName: Kininogen-1 alternativeName: Alpha-2-thiol proteinase inhibitor alternativeName: Fitzgerald factor alternativeName: High molecular weight kininogen shortName: HMWK alternativeName: Williams-Fitzgerald-Flaujeac factor component recommendedName: Kininogen-1 heavy chain /component component recommendedName: T-kinin alternativeName: Ile-Ser-Bradykinin /component component recommendedName: fullName evidence="34"Bradykinin alternativeName: Kallidin I /component component recommendedName: Lysyl-bradykinin alternativeName: Kallidin II /component component recommendedName: Kininogen-1 light chain /component component recommendedName: Low molecular weight growth-promoting factor /component
geneName	KNG1 BDK KNG
identifier	P01042
isSequenceChanged	FALSE
keyword	3D-structure Alternative splicing Blood coagulation Direct protein sequencing Disease variant Disulfide bond Glycoprotein Hemostasis Hydroxylation Inflammatory response Phosphoprotein Protease inhibitor Proteomics identification Pyrrolidone carboxylic acid Reference proteome Repeat Secreted Signal Thiol protease inhibitor Vasoactive Vasodilator
modified	[InstanceEdit:9836292] Weiser, Joel, 2023-05-25 [InstanceEdit:9852000] Weiser, Joel, 2023-11-03 [InstanceEdit:9926675] Weiser, Joel, 2024-11-03 [InstanceEdit:9939033] Weiser, Joel, 2025-02-21 [InstanceEdit:9948485] Weiser, Joel, 2025-05-21
name	KNG1
referenceDatabase	[ReferenceDatabase:2] UniProt
referenceGene	[ReferenceDNASequence:8958004] ENSEMBL:ENSG00000113889 KNG1 [Homo sapiens]
secondaryIdentifier	KNG1_HUMAN A8K474 B2RCR2 C9JEX1 P01043 Q53EQ0 Q6PAU9 Q7M4P1
sequenceLength	644
species	[Species:48887] Homo sapiens
(isoformParent)	[ReferenceIsoform:149451] UniProt:P01042-2 KNG1 [Homo sapiens] [ReferenceIsoform:402240] UniProt:P01042-1 KNG1 [Homo sapiens] [ReferenceIsoform:8965665] UniProt:P01042-3 KNG1 [Homo sapiens]
(referenceEntity)	[EntityWithAccessionedSequence:139864] KNG1(19-644) [platelet alpha granule lumen] [Homo sapiens] [EntityWithAccessionedSequence:158125] KNG1(19-644) [extracellular region] [Homo sapiens] [EntityWithAccessionedSequence:158245] KNG1(19-380) [plasma membrane] [Homo sapiens] [EntityWithAccessionedSequence:158269] KNG1(19-644) [plasma membrane] [Homo sapiens] [EntityWithAccessionedSequence:158279] KNG1(390-644) [plasma membrane] [Homo sapiens] [EntityWithAccessionedSequence:158344] Bradykinin [extracellular region] [Homo sapiens] [EntityWithAccessionedSequence:8956767] KNG1 [endoplasmic reticulum lumen] [Homo sapiens] [EntityWithAccessionedSequence:8956939] p-KNG1 [endoplasmic reticulum lumen] [Homo sapiens] [EntityWithAccessionedSequence:9970719] des-Arg9-bradykinin [extracellular region] [Homo sapiens]
(referenceSequence)	[ModifiedResidue:8956893] phosphorylated residue at unknown position
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No pathways have been reviewed or authored by UniProt:P01042 KNG1 (58181)