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Details on Person UniProt:Q9P0G3 KLK14
| Class:Id | ReferenceGeneProduct:58165 |
|---|---|
| _chainChangeLog | signal peptide:1-34 added on Fri February 6 2015;propeptide:35-40 added on Fri February 6 2015;chain:41-267 added on Fri February 6 2015;signal peptide:1-34 for 58165 removed on Fri Feb 20 2026;propeptide:35-40 for 58165 removed on Fri Feb 20 2026;chain:41-267 for 58165 removed on Fri Feb 20 2026;signal peptide:1-18 for 58165 added on Fri Feb 20 2026;propeptide:19-24 for 58165 added on Fri Feb 20 2026;chain:25-251 for 58165 added on Fri Feb 20 2026 |
| _displayName | UniProt:Q9P0G3 KLK14 |
| _timestamp | 2026-05-15 20:13:26 |
| chain | signal peptide:1-18 propeptide:19-24 chain:25-251 |
| checksum | 9087953BAFA7ED25 |
| comment | FUNCTION Serine-type endopeptidase with a dual trypsin-like and chymotrypsin-like substrate specificity. May activate/inactivate the proteinase-activated receptors F2R, F2RL1 and F2RL3 and other kallikreins including KLK1, KLK3, KLK5 and KLK11. May function in seminal clot liquefaction through direct cleavage of the semenogelin SEMG1 and SEMG2 and activation of KLK3. May function through desmoglein DSG1 cleavage in epidermal desquamation a process by which the most superficial corneocytes are shed from the skin surface. May be involved in several aspects of tumor progression including growth, invasion and angiogenesis.ACTIVITY REGULATION Inhibited by SERPINA1, SERPINC1, SERPINE1, SERPINF2, aprotinin, soybean, trypsin inhibitor and leupeptin. Inhibited by serine protease inhibitor SPINK5. Has an autoproteolytic activity which may have a regulatory effect. Activated by citrate and inhibited by zinc and to a lower extent by manganese.BIOPHYSICOCHEMICAL PROPERTIES Has a higher catalytic efficiency for the trypsin-like enzyme substrates S-2288, S-2222 and S-2302 compared to S-2586 a chymotrypsin-like enzyme substrate. Has a lower catalytic activity compared to trypsin towards S-2288, S-2222 and S-2302. Cleaves preferentially after Arg residues.SUBCELLULAR LOCATION Highly expressed in CNS, bone marrow and fetal liver. Also expressed in breast, thyroid, kidney, colon, pancreas, spleen, prostate, uterus, small intestine, placenta and skeletal muscle. Among 40 tissues tested, the highest expression is detected in skin followed by breast and prostate (at protein level). Expressed in stratum corneum by sweat ducts and sweat glands and detected in sweat (at protein level).INDUCTION Up-regulated by steroid hormone.PTM Proteolytic cleavage of the activation peptide produces the active enzyme.SIMILARITY Belongs to the peptidase S1 family. Kallikrein subfamily.SEQUENCE CAUTION Extended N-terminus.SEQUENCE CAUTION Extended N-terminus.SEQUENCE CAUTION Extended N-terminus. |
| description | recommendedName: Kallikrein-14 shortName: hK14 ecNumber evidence="8"3.4.21.- alternativeName: Kallikrein-like protein 6 shortName: KLK-L6 |
| geneName | KLK14 KLKL6 |
| identifier | Q9P0G3 |
| isSequenceChanged | FALSE |
| keyword | Autocatalytic cleavage Direct protein sequencing Disulfide bond Hydrolase Protease Proteomics identification Reference proteome Secreted Serine protease Signal Zymogen |
| modified | [InstanceEdit:9836292] Weiser, Joel, 2023-05-25 [InstanceEdit:9852000] Weiser, Joel, 2023-11-03 [InstanceEdit:9926675] Weiser, Joel, 2024-11-03 [InstanceEdit:9983091] Weiser, Joel, 2026-02-20 [InstanceEdit:9989145] Weiser, Joel, 2026-05-15 |
| name | KLK14 |
| referenceDatabase | [ReferenceDatabase:2] UniProt |
| referenceGene | [ReferenceDNASequence:9001237] ENSEMBL:ENSG00000129437 KLK14 [Homo sapiens] |
| secondaryIdentifier | KLK14_HUMAN A0A1R3UHJ7 A7UNK5 Q1RMZ2 Q6B089 |
| sequenceLength | 251 |
| species | [Species:48887] Homo sapiens |
| (referenceEntity) | [EntityWithAccessionedSequence:5694595] KLK14 [extracellular region] [Homo sapiens] |
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No pathways have been reviewed or authored by UniProt:Q9P0G3 KLK14 (58165)
