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Details on Person UniProt:O75838 CIB2

Class:Id	ReferenceGeneProduct:58089
_chainChangeLog	chain:1-187 added on Sat February 7 2015
_displayName	UniProt:O75838 CIB2
_timestamp	2026-02-20 21:38:16
chain	chain:1-187
checksum	D51F6C25AD381BEF
comment	FUNCTION Calcium- and integrin-binding protein that plays a role in intracellular calcium homeostasis (By similarity). Acts as an auxiliary subunit of the sensory mechanoelectrical transduction (MET) channel in hair cells (By similarity). Essential for mechanoelectrical transduction (MET) currents in auditory hair cells and thereby required for hearing (By similarity). Regulates the function of hair cell mechanotransduction by controlling the distribution of transmembrane channel-like proteins TMC1 and TMC2, and by regulating the function of the MET channels in hair cells (By similarity). Required for the maintenance of auditory hair cell stereocilia bundle morphology and function and for hair-cell survival in the cochlea (By similarity). Critical for proper photoreceptor cell maintenance and function (By similarity). Plays a role in intracellular calcium homeostasis by decreasing ATP-induced calcium release (PubMed:23023331, PubMed:26173970, PubMed:26426422).SUBUNIT Monomer (PubMed:31636333). Homodimer (PubMed:23023331). Interacts with WHRN and MYO7A (PubMed:23023331, PubMed:26426422). Interacts with ITGA2B (via C-terminus cytoplasmic tail region); the interactions are stabilized/increased in a calcium and magnesium-dependent manner (PubMed:22779914). Interacts with ITGA7 (via C-terminus cytoplasmic tail region); the interactions are stabilized/increased in a calcium and magnesium-dependent manner (PubMed:22779914). Interacts with TMC1 (PubMed:28663585, PubMed:34089643). Interacts with TMC2 (PubMed:28663585).INTERACTION Colocalizes with ITGA7 at the myotendinous junctions (MTJ) and at the neuromuscular junctions (NMJ) (By similarity). Located mainly in stereocilia and at the apical surface of hair cells of the cochlea (By similarity). Localizes in the cuticular plate along and at the tip of the stereocilia of vestibular sensory hair cells (PubMed:26173970, PubMed:26426422).ALTERNATIVE PRODUCTS Widely expressed (PubMed:23023331).MASS SPECTROMETRY The disease is caused by variants affecting the gene represented in this entry.DISEASE The disease is caused by variants affecting the gene represented in this entry.MISCELLANEOUS The binding of either calcium or magnesium significantly increases the structural stability of the protein in comparison to apo-CIB (calcium- and magnesium-free form) (PubMed:22779914).
description	recommendedName: Calcium and integrin-binding family member 2 alternativeName: Kinase-interacting protein 2 shortName: KIP 2
geneName	CIB2 KIP2
identifier	O75838
isSequenceChanged	FALSE
keyword	3D-structure Alternative splicing Calcium Cell membrane Cell projection Cilium Cytoplasm Deafness Disease variant Magnesium Membrane Metal-binding Non-syndromic deafness Proteomics identification Reference proteome Repeat Retinitis pigmentosa Usher syndrome
modified	[InstanceEdit:9836292] Weiser, Joel, 2023-05-25 [InstanceEdit:9852000] Weiser, Joel, 2023-11-03 [InstanceEdit:9862192] Weiser, Joel, 2024-02-26 [InstanceEdit:9926675] Weiser, Joel, 2024-11-03 [InstanceEdit:9963647] Weiser, Joel, 2025-08-15 [InstanceEdit:9983091] Weiser, Joel, 2026-02-20
name	CIB2
referenceDatabase	[ReferenceDatabase:2] UniProt
referenceGene	[ReferenceDNASequence:8993531] ENSEMBL:ENSG00000136425 CIB2 [Homo sapiens]
secondaryIdentifier	CIB2_HUMAN B4DDF0 H0YM71 Q05BT6
sequenceLength	187
species	[Species:48887] Homo sapiens
(isoformParent)	[ReferenceIsoform:8965520] UniProt:O75838-1 CIB2 [Homo sapiens] [ReferenceIsoform:8965521] UniProt:O75838-2 CIB2 [Homo sapiens] [ReferenceIsoform:8965522] UniProt:O75838-3 CIB2 [Homo sapiens] [ReferenceIsoform:8965523] UniProt:O75838-4 CIB2 [Homo sapiens]
(referenceEntity)	[EntityWithAccessionedSequence:9658866] CIB2 [cytosol] [Homo sapiens]
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No pathways have been reviewed or authored by UniProt:O75838 CIB2 (58089)