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Details on Person UniProt:P33176 KIF5B
| Class:Id | ReferenceGeneProduct:58083 |
|---|---|
| _chainChangeLog | initiator methionine:1 added on Fri February 6 2015;chain:2-963 added on Fri February 6 2015;initiator methionine:1 for 58083 removed on Fri Nov 03 2023;initiator methionine: for 58083 added on Fri Nov 03 2023;initiator methionine: for 58083 removed on Fri Aug 15 2025;initiator methionine:1 for 58083 added on Fri Aug 15 2025 |
| _displayName | UniProt:P33176 KIF5B |
| _timestamp | 2025-08-15 21:23:39 |
| chain | initiator methionine:1 chain:2-963 |
| checksum | A1FE5760C3250C8B |
| comment | FUNCTION Microtubule-dependent motor required for normal distribution of mitochondria and lysosomes. Can induce formation of neurite-like membrane protrusions in non-neuronal cells in a ZFYVE27-dependent manner (By similarity). Regulates centrosome and nuclear positioning during mitotic entry. During the G2 phase of the cell cycle in a BICD2-dependent manner, antagonizes dynein function and drives the separation of nuclei and centrosomes (PubMed:20386726). Required for anterograde axonal transportation of MAPK8IP3/JIP3 which is essential for MAPK8IP3/JIP3 function in axon elongation (By similarity). Through binding with PLEKHM2 and ARL8B, directs lysosome movement toward microtubule plus ends (Probable). Involved in NK cell-mediated cytotoxicity. Drives the polarization of cytolytic granules and microtubule-organizing centers (MTOCs) toward the immune synapse between effector NK lymphocytes and target cells (PubMed:24088571).SUBUNIT Oligomer composed of two heavy chains and two light chains. Interacts with GRIP1 and PPP1R42 (By similarity). Interacts with SYBU (PubMed:15459722). Interacts with JAKMIP1 (PubMed:17532644). Interacts with PLEKHM2 (PubMed:15905402). Interacts with ECPAS (PubMed:20682791). Interacts with ZFYVE27 (By similarity). Found in a complex with OGT, RHOT1, RHOT2 and TRAK1 (PubMed:24995978). Interacts with APP (via cytoplasmic domain) (PubMed:23011729).INTERACTION Uniformly distributed between soma and neurites in hippocampal neurons.DOMAIN Composed of three structural domains: a large globular N-terminal domain which is responsible for the motor activity of kinesin (it hydrolyzes ATP and binds microtubule), a central alpha-helical coiled coil domain that mediates the heavy chain dimerization; and a small globular C-terminal domain which interacts with other proteins (such as the kinesin light chains), vesicles and membranous organelles.SIMILARITY Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Kinesin family. Kinesin subfamily. |
| description | recommendedName: fullName evidence="16"Kinesin-1 heavy chain alternativeName: Conventional kinesin heavy chain alternativeName: Ubiquitous kinesin heavy chain shortName: UKHC |
| geneName | KIF5B KNS KNS1 |
| identifier | P33176 |
| isSequenceChanged | FALSE |
| keyword | 3D-structure Acetylation ATP-binding Coiled coil Cytoplasm Cytoskeleton Isopeptide bond Lysosome Membrane Methylation Microtubule Motor protein Nucleotide-binding Phosphoprotein Proteomics identification Reference proteome Ubl conjugation |
| modified | [InstanceEdit:9836292] Weiser, Joel, 2023-05-25 [InstanceEdit:9852000] Weiser, Joel, 2023-11-03 [InstanceEdit:9926675] Weiser, Joel, 2024-11-03 [InstanceEdit:9963647] Weiser, Joel, 2025-08-15 |
| name | KIF5B |
| referenceDatabase | [ReferenceDatabase:2] UniProt |
| referenceGene | [ReferenceDNASequence:8993113] ENSEMBL:ENSG00000170759 KIF5B [Homo sapiens] |
| secondaryIdentifier | KINH_HUMAN A0AVB2 Q5VZ85 |
| sequenceLength | 963 |
| species | [Species:48887] Homo sapiens |
| (referenceEntity) | [EntityWithAccessionedSequence:265181] KIF5B [cytosol] [Homo sapiens] [EntityWithAccessionedSequence:3878113] KIF5B [endoplasmic reticulum membrane] [Homo sapiens] [EntityWithAccessionedSequence:9020738] p-KIF5B [cytosol] [Homo sapiens] [EntityWithAccessionedSequence:9711937] KIF5B(2-575)-p-7Y-ALK(1063-1620) fusion [cytosol] [Homo sapiens] [EntityWithAccessionedSequence:9711964] KIF5B(2-575)-ALK(1063-1620) fusion [cytosol] [Homo sapiens] |
| (referenceSequence) | [ModifiedResidue:9020844] phosphorylated residue at unknown position |
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No pathways have been reviewed or authored by UniProt:P33176 KIF5B (58083)
