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Details on Person UniProt:O00139 KIF2A
| Class:Id | ReferenceGeneProduct:58077 |
|---|---|
| _chainChangeLog | chain:1-706 added on Fri February 6 2015 |
| _displayName | UniProt:O00139 KIF2A |
| _timestamp | 2025-08-15 21:23:37 |
| chain | chain:1-706 |
| checksum | A407D84B6BD04ACF |
| comment | FUNCTION Plus end-directed microtubule-dependent motor required for normal brain development. May regulate microtubule dynamics during axonal growth. Required for normal progression through mitosis. Required for normal congress of chromosomes at the metaphase plate. Required for normal spindle dynamics during mitosis. Promotes spindle turnover. Implicated in formation of bipolar mitotic spindles. Has microtubule depolymerization activity.SUBUNIT Interacts with AURKA and PLK1 (PubMed:19351716). Interacts with PSRC1 (PubMed:18411309). Interacts with MCRS1; the interaction enhances recruitment of KIF2A to the minus ends of spindle microtubules which promotes chromosome alignment (PubMed:30785839).INTERACTION Localized to the spindle microtubules and spindle poles from prophase to metaphase. Efficient targeting to spindle microtubules and spindle poles requires the kinase activity of PLK1. Recruited to mitotic spindles by interaction with PSRC1.ALTERNATIVE PRODUCTS The disease is caused by variants affecting the gene represented in this entry.MISCELLANEOUS HeLa cells lacking KIF2A show asymmetric or monopolar mitotic spindles. Osteosarcoma cells (U2OS) lacking KIF2A or KIF2B show disorganised or monopolar mitotic spindles.SIMILARITY Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Kinesin family. MCAK/KIF2 subfamily.SEQUENCE CAUTION Truncated N-terminus. |
| description | recommendedName: Kinesin-like protein KIF2A alternativeName: Kinesin-2 shortName: hK2 |
| geneName | KIF2A KIF2 KNS2 |
| identifier | O00139 |
| isSequenceChanged | FALSE |
| keyword | 3D-structure Acetylation Alternative splicing ATP-binding Cell cycle Cell division Coiled coil Cytoplasm Cytoskeleton Developmental protein Differentiation Disease variant Lissencephaly Microtubule Mitosis Motor protein Neurogenesis Nucleotide-binding Phosphoprotein Proteomics identification Reference proteome |
| modified | [InstanceEdit:9836292] Weiser, Joel, 2023-05-25 [InstanceEdit:9852000] Weiser, Joel, 2023-11-03 [InstanceEdit:9926675] Weiser, Joel, 2024-11-03 [InstanceEdit:9963647] Weiser, Joel, 2025-08-15 |
| name | KIF2A |
| referenceDatabase | [ReferenceDatabase:2] UniProt |
| referenceGene | [ReferenceDNASequence:8993703] ENSEMBL:ENSG00000068796 KIF2A [Homo sapiens] |
| secondaryIdentifier | KIF2A_HUMAN A5YM42 A5YM54 B4DY54 D3DW97 E9PB70 Q7Z5I3 Q8N5Q7 |
| sequenceLength | 706 |
| species | [Species:48887] Homo sapiens |
| (isoformParent) | [ReferenceIsoform:234379] UniProt:O00139-3 KIF2A [Homo sapiens] [ReferenceIsoform:234380] UniProt:O00139-2 KIF2A [Homo sapiens] [ReferenceIsoform:234381] UniProt:O00139-4 KIF2A [Homo sapiens] [ReferenceIsoform:401081] UniProt:O00139-1 KIF2A [Homo sapiens] [ReferenceIsoform:8967030] UniProt:O00139-5 KIF2A [Homo sapiens] |
| (referenceEntity) | [EntityWithAccessionedSequence:376232] KIF2A [cytosol] [Homo sapiens] |
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No pathways have been reviewed or authored by UniProt:O00139 KIF2A (58077)
