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Details on Person UniProt:Q99661 KIF2C
| Class:Id | ReferenceGeneProduct:58017 |
|---|---|
| _chainChangeLog | initiator methionine:1 added on Fri February 6 2015;chain:2-725 added on Fri February 6 2015;initiator methionine:1 for 58017 removed on Fri Nov 03 2023;initiator methionine: for 58017 added on Fri Nov 03 2023;initiator methionine: for 58017 removed on Fri Aug 15 2025;initiator methionine:1 for 58017 added on Fri Aug 15 2025 |
| _displayName | UniProt:Q99661 KIF2C |
| _timestamp | 2025-08-15 21:23:39 |
| chain | initiator methionine:1 chain:2-725 |
| checksum | 5BDECC133AB4B55C |
| comment | FUNCTION In complex with KIF18B, constitutes the major microtubule plus-end depolymerizing activity in mitotic cells (PubMed:21820309). Regulates the turnover of microtubules at the kinetochore and functions in chromosome segregation during mitosis (PubMed:19060894). Plays a role in chromosome congression and is required for the lateral to end-on conversion of the chromosome-microtubule attachment (PubMed:23891108).SUBUNIT Interacts with CENPH. Interacts with MTUS2/TIP150; the interaction is direct. Interacts with MAPRE1; the interaction is direct, regulated by phosphorylation and is probably required for targeting to growing microtubule plus ends. Interacts with KIF18B at microtubule tips; this interaction increases the affinity of both partners for microtubule plus ends and is required for robust microtubule depolymerization. Phosphorylation by AURKA or AURKB strongly reduces KIF18B-binding.INTERACTION Associates with the microtubule network at the growing distal tip (the plus-end) of microtubules, probably through interaction with MTUS2/TIP150 and MAPRE1 (By similarity). Association with microtubule plus ends is also mediated by interaction with KIF18B. Centromeric localization requires the presence of BUB1 and SGO2.ALTERNATIVE PRODUCTS Expressed at high levels in thymus and testis, at low levels in small intestine, the mucosal lining of colon, and placenta, and at very low levels in spleen and ovary; expression is not detected in prostate, peripheral blood Leukocytes, heart, brain, lung, liver, skeletal muscle, kidney or pancreas. Isoform 2 is testis-specific.DEVELOPMENTAL STAGE Isoform 2 is expressed in fetal testis.DOMAIN The microtubule tip localization signal (MtLS) motif; mediates interaction with MAPRE1 and targeting to the growing microtubule plus ends.PTM Phosphorylation by AURKB, regulates association with centromeres and kinetochores and the microtubule depolymerization activity.PTM Ubiquitinated.SIMILARITY Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Kinesin family. MCAK/KIF2 subfamily. |
| description | recommendedName: Kinesin-like protein KIF2C alternativeName: Kinesin-like protein 6 alternativeName: Mitotic centromere-associated kinesin shortName: MCAK |
| geneName | KIF2C KNSL6 |
| identifier | Q99661 |
| isSequenceChanged | FALSE |
| keyword | 3D-structure Acetylation Alternative splicing ATP-binding Cell cycle Cell division Centromere Chromosome Chromosome partition Coiled coil Cytoplasm Cytoskeleton Kinetochore Microtubule Mitosis Nucleotide-binding Nucleus Phosphoprotein Proteomics identification Reference proteome Ubl conjugation |
| modified | [InstanceEdit:9836292] Weiser, Joel, 2023-05-25 [InstanceEdit:9852000] Weiser, Joel, 2023-11-03 [InstanceEdit:9926675] Weiser, Joel, 2024-11-03 [InstanceEdit:9963647] Weiser, Joel, 2025-08-15 |
| name | KIF2C |
| referenceDatabase | [ReferenceDatabase:2] UniProt |
| referenceGene | [ReferenceDNASequence:8997228] ENSEMBL:ENSG00000142945 KIF2C [Homo sapiens] |
| secondaryIdentifier | KIF2C_HUMAN B3ITR9 Q5JR88 Q6ICU1 Q96C18 Q96HB8 Q9BWV8 |
| sequenceLength | 725 |
| species | [Species:48887] Homo sapiens |
| (isoformParent) | [ReferenceIsoform:149323] UniProt:Q99661-2 KIF2C [Homo sapiens] [ReferenceIsoform:413159] UniProt:Q99661-1 KIF2C [Homo sapiens] |
| (referenceEntity) | [EntityWithAccessionedSequence:376256] KIF2C [cytosol] [Homo sapiens] |
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No pathways have been reviewed or authored by UniProt:Q99661 KIF2C (58017)
