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Details on Person UniProt:Q92504 SLC39A7
| Class:Id | ReferenceGeneProduct:57987 |
|---|---|
| _chainChangeLog | chain:1-469 added on Fri February 6 2015 |
| _displayName | UniProt:Q92504 SLC39A7 |
| _timestamp | 2025-02-21 18:51:25 |
| chain | chain:1-469 |
| checksum | 6504A1EF5AA6A5B9 |
| comment | FUNCTION Transports Zn(2+) from the endoplasmic reticulum (ER)/Golgi apparatus to the cytosol, playing an essential role in the regulation of cytosolic zinc levels (PubMed:14525538, PubMed:15705588, PubMed:28205653, PubMed:29980658). Acts as a gatekeeper of zinc release from intracellular stores, requiring post-translational activation by phosphorylation, resulting in activation of multiple downstream pathways leading to cell growth and proliferation (PubMed:22317921, PubMed:28205653, PubMed:29980658). Has an essential role in B cell development and is required for proper B cell receptor signaling (PubMed:30718914). Plays an important role in maintaining intestinal epithelial homeostasis and skin dermis development by regulating ER function (By similarity). Controls cell signaling pathways involved in glucose metabolism in skeletal muscle (By similarity). Has a protective role against ER stress in different biological contexts (PubMed:29980658, PubMed:30237509). Mediates Zn(2+)-induced ferroptosis (PubMed:33608508).CATALYTIC ACTIVITY Zn(2+)(in) = Zn(2+)(out)ACTIVITY REGULATION Phosphorylation activates zinc transport activity.SUBUNIT Homodimer.INTERACTION Widely expressed.INDUCTION Down-regulated by Zn(+2).PTM Rapidly phosphorylated by CK2 following Zn(2+) treatment. This phosphorylation is required for efficient cytosolic Zn(2+) release.PTM Methylation at some His residue by METTL9 leads to reduced zinc-binding.DISEASE The disease is caused by variants affecting the gene represented in this entry.SIMILARITY Belongs to the ZIP transporter (TC 2.A.5) family. KE4/Catsup subfamily. |
| description | recommendedName: Zinc transporter SLC39A7 alternativeName: fullName evidence="16"Histidine-rich membrane protein Ke4 alternativeName: Really interesting new gene 5 protein alternativeName: Solute carrier family 39 member 7 alternativeName: fullName evidence="17"Zrt-, Irt-like protein 7 shortName evidence="17"ZIP7 |
| geneName | SLC39A7 HKE4 RING5 |
| identifier | Q92504 |
| isSequenceChanged | FALSE |
| keyword | 3D-structure Disease variant Endoplasmic reticulum Golgi apparatus Ion transport Membrane Methylation Phosphoprotein Proteomics identification Reference proteome Transmembrane Transmembrane helix Transport Zinc Zinc transport |
| modified | [InstanceEdit:84067] Schmidt, EE, 2003-12-18 04:29:09 [InstanceEdit:143527] Schmidt, EE, 2004-11-12 07:45:10 [InstanceEdit:217385] Schmidt, EE, 2008-03-27 06:23:53 [InstanceEdit:354386] Schmidt, EE, 2008-06-18 04:45:12 [InstanceEdit:384350] Kanapin, AA, 2008-11-26 14:00:39 [InstanceEdit:392885] Kanapin, AA, 2009-03-09 12:07:18 [InstanceEdit:400710] Schmidt, EE, 2009-03-25 05:33:35 [InstanceEdit:423310] Kanapin, AA [InstanceEdit:435478] Kanapin, AA [InstanceEdit:435871] Kanapin, AA [InstanceEdit:447347] Kanapin, AA [InstanceEdit:525883] Kanapin, AA [InstanceEdit:613449] Kanapin, AA [InstanceEdit:797602] Kanapin, AA [InstanceEdit:937368] Yung, CK [InstanceEdit:1042053] Yung, CK [InstanceEdit:1220657] Yung, CK [InstanceEdit:1300696] Yung, CK [InstanceEdit:1301627] Yung, CK [InstanceEdit:1551960] Weiser, JD [InstanceEdit:1995863] Weiser, JD [InstanceEdit:2132304] Weiser, JD [InstanceEdit:2265580] Weiser, JD [InstanceEdit:5083144] Weiser, JD [InstanceEdit:5433710] Weiser, JD [InstanceEdit:5618415] Weiser, JD [InstanceEdit:5634237] Weiser, JD [InstanceEdit:5673015] Weiser, JD [InstanceEdit:8944791] Weiser, JD [InstanceEdit:8964659] Weiser, JD [InstanceEdit:8987656] Weiser, JD [InstanceEdit:9037114] Weiser, JD [InstanceEdit:9637257] Weiser, JD [InstanceEdit:9676415] Weiser, JD [InstanceEdit:9715482] Weiser, JD [InstanceEdit:9750299] Weiser, JD [InstanceEdit:9819394] Weiser, Joel [InstanceEdit:9834092] Weiser, Joel [InstanceEdit:9852000] Weiser, Joel, 2023-11-03 [InstanceEdit:9862192] Weiser, Joel, 2024-02-26 [InstanceEdit:9917590] Weiser, Joel, 2024-08-09 [InstanceEdit:9926675] Weiser, Joel, 2024-11-03 [InstanceEdit:9939033] Weiser, Joel, 2025-02-21 |
| name | SLC39A7 |
| referenceDatabase | [ReferenceDatabase:2] UniProt |
| referenceGene | [ReferenceDNASequence:8996861] ENSEMBL:ENSG00000112473 SLC39A7 [Homo sapiens] |
| secondaryIdentifier | S39A7_HUMAN B0UXF6 Q5STP8 Q9UIQ0 |
| sequenceLength | 469 |
| species | [Species:48887] Homo sapiens |
| (referenceEntity) | [EntityWithAccessionedSequence:442363] SLC39A7 [endoplasmic reticulum membrane] [Homo sapiens] |
| [Change default viewing format] | |
No pathways have been reviewed or authored by UniProt:Q92504 SLC39A7 (57987)
