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Details on Person UniProt:P17540 CKMT2
| Class:Id | ReferenceGeneProduct:57949 |
|---|---|
| _chainChangeLog | transit peptide:1-39 added on Sat February 7 2015;chain:40-419 added on Sat February 7 2015 |
| _displayName | UniProt:P17540 CKMT2 |
| _timestamp | 2025-02-21 19:49:14 |
| chain | transit peptide:1-39 chain:40-419 |
| checksum | 0CAF000074D99B6F |
| comment | FUNCTION Reversibly catalyzes the transfer of phosphate between ATP and various phosphogens (e.g. creatine phosphate). Creatine kinase isoenzymes play a central role in energy transduction in tissues with large, fluctuating energy demands, such as skeletal muscle, heart, brain and spermatozoa.CATALYTIC ACTIVITY creatine + ATP = N-phosphocreatine + ADP + H(+)SUBUNIT Exists as an octamer composed of four CKMT2 homodimers.INTERACTION Sarcomere-specific. Found only in heart and skeletal muscles.MISCELLANEOUS Mitochondrial creatine kinase binds cardiolipin.SIMILARITY Belongs to the ATP:guanido phosphotransferase family. |
| description | recommendedName: Creatine kinase S-type, mitochondrial ecNumber: 2.7.3.2 alternativeName: Basic-type mitochondrial creatine kinase shortName: Mib-CK alternativeName: Sarcomeric mitochondrial creatine kinase shortName: S-MtCK |
| geneName | CKMT2 |
| identifier | P17540 |
| isSequenceChanged | FALSE |
| keyword | 3D-structure ATP-binding Direct protein sequencing Kinase Membrane Mitochondrion Mitochondrion inner membrane Nucleotide-binding Phosphoprotein Proteomics identification Reference proteome Transferase Transit peptide |
| modified | [InstanceEdit:9836292] Weiser, Joel, 2023-05-25 [InstanceEdit:9852000] Weiser, Joel, 2023-11-03 [InstanceEdit:9926675] Weiser, Joel, 2024-11-03 [InstanceEdit:9939033] Weiser, Joel, 2025-02-21 |
| name | CKMT2 |
| referenceDatabase | [ReferenceDatabase:2] UniProt |
| referenceGene | [ReferenceDNASequence:8994885] ENSEMBL:ENSG00000131730 CKMT2 [Homo sapiens] |
| secondaryIdentifier | KCRS_HUMAN Q6ICS8 Q8N1E1 |
| sequenceLength | 419 |
| species | [Species:48887] Homo sapiens |
| (referenceEntity) | [EntityWithAccessionedSequence:200325] CKMT2 [mitochondrial inner membrane] [Homo sapiens] |
| [Change default viewing format] | |
No pathways have been reviewed or authored by UniProt:P17540 CKMT2 (57949)
