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Details on Person UniProt:Q9H2S1 KCNN2
| Class:Id | ReferenceGeneProduct:57939 |
|---|---|
| _chainChangeLog | chain:1-579 added on Fri February 6 2015 |
| _displayName | UniProt:Q9H2S1 KCNN2 |
| _timestamp | 2024-11-03 19:46:24 |
| chain | chain:1-579 |
| checksum | 2ED87FE13C106183 |
| comment | FUNCTION Small conductance calcium-activated potassium channel that mediates the voltage-independent transmembrane transfer of potassium across the cell membrane through a constitutive interaction with calmodulin which binds the intracellular calcium allowing its opening (PubMed:10991935, PubMed:33242881, PubMed:9287325). The current is characterized by a voltage-independent activation, an intracellular calcium concentration increase-dependent activation and a single-channel conductance of about 3 picosiemens (PubMed:10991935). Also presents an inwardly rectifying current, thus reducing its already small outward conductance of potassium ions, which is particularly the case when the membrane potential displays positive values, above + 20 mV (PubMed:10991935). The inward rectification could be due to a blockade of the outward current by intracellular divalent cations such as calcium and magnesium and could also be due to an intrinsic property of the channel pore, independent of intracellular divalent ions. There are three positively charged amino acids in the S6 transmembrane domain, close to the pore, that collectively control the conductance and rectification through an electrostatic mechanism. Additionally, electrostatic contributions from these residues also play an important role in determining the intrinsic open probability of the channel in the absence of calcium, affecting the apparent calcium affinity for activation. Forms an heteromeric complex with calmodulin, which is constitutively associated in a calcium-independent manner. Channel opening is triggered when calcium binds the calmodulin resulting in a rotary movement leading to the formation of the dimeric complex to open the gate (By similarity). Plays a role in the repolarization phase of cardiac action potential (PubMed:13679367).CATALYTIC ACTIVITY K(+)(in) = K(+)(out)ACTIVITY REGULATION Inhibited by bee venom neurotoxin apamin (PubMed:10991935, PubMed:9287325). Inhibited by UCL 1684 and tetraethylammonium (TEA) (By similarity).SUBUNIT Homodimer (PubMed:20689065). Heteromultimer with KCNN1 and KCNN3 (PubMed:20689065, PubMed:9287325). The complex is composed of 4 channel subunits each of which binds to a calmodulin subunit which regulates the channel activity through calcium-binding (By similarity). Interacts (via N-terminal domain) with MPP2 (By similarity).INTERACTION Expressed in atrial myocytes (at protein level) (PubMed:13679367). Widely expressed.DOMAIN The coiled-coil domaim mediates heteromeic assembly.DOMAIN The calmodulin-binding domain (CaMBD) forms an elongated dimer with a calmodulin molecule bound at each end; each calmodulin wraps around three alpha-helices, two from one CaMBD subunit and one from the other.DISEASE The disease may be caused by variants affecting the gene represented in this entry.DISEASE The disease is caused by variants affecting the gene represented in this entry.SIMILARITY Belongs to the potassium channel KCNN family. KCa2.2/KCNN2 subfamily. |
| description | recommendedName: fullName evidence="13"Small conductance calcium-activated potassium channel protein 2 shortName: SK2 shortName: SKCa 2 shortName: SKCa2 alternativeName: KCa2.2 |
| geneName | KCNN2 |
| identifier | Q9H2S1 |
| isSequenceChanged | FALSE |
| keyword | 3D-structure Alternative splicing Calmodulin-binding Cytoplasm Disease variant Dystonia Intellectual disability Ion channel Ion transport Membrane Phosphoprotein Proteomics identification Reference proteome Transmembrane Transmembrane helix Transport |
| modified | [InstanceEdit:9836292] Weiser, Joel, 2023-05-25 [InstanceEdit:9852000] Weiser, Joel, 2023-11-03 [InstanceEdit:9917590] Weiser, Joel, 2024-08-09 [InstanceEdit:9926675] Weiser, Joel, 2024-11-03 |
| name | KCNN2 |
| referenceDatabase | [ReferenceDatabase:2] UniProt |
| referenceGene | [ReferenceDNASequence:8988461] ENSEMBL:ENSG00000080709 KCNN2 [Homo sapiens] |
| secondaryIdentifier | KCNN2_HUMAN A6NF94 Q0VFZ4 Q6PJI0 Q6X2Y2 |
| sequenceLength | 579 |
| species | [Species:48887] Homo sapiens |
| (isoformParent) | [ReferenceIsoform:8968334] UniProt:Q9H2S1-1 KCNN2 [Homo sapiens] [ReferenceIsoform:8968335] UniProt:Q9H2S1-2 KCNN2 [Homo sapiens] |
| (referenceEntity) | [EntityWithAccessionedSequence:977492] KCNN2 [plasma membrane] [Homo sapiens] |
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No pathways have been reviewed or authored by UniProt:Q9H2S1 KCNN2 (57939)
