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Details on Person UniProt:Q92952 KCNN1
| Class:Id | ReferenceGeneProduct:57937 |
|---|---|
| _chainChangeLog | chain:1-543 added on Fri February 6 2015 |
| _displayName | UniProt:Q92952 KCNN1 |
| _timestamp | 2024-11-03 19:46:24 |
| chain | chain:1-543 |
| checksum | 13EFF47C263BCB11 |
| comment | FUNCTION Small conductance calcium-activated potassium channel that mediates the voltage-independent transmembrane transfer of potassium across the cell membrane through a constitutive interaction with calmodulin which binds the intracellular calcium allowing its opening (PubMed:17142458, PubMed:8781233, PubMed:9287325). The current is characterized by a voltage-independent activation, an intracellular calcium concentration increase-dependent activation and a single-channel conductance of about 3 picosiemens (PubMed:8781233). Also presents an inwardly rectifying current, thus reducing its already small outward conductance of potassium ions, which is particularly the case when the membrane potential displays positive values, above + 20 mV (Probable). Activation is followed by membrane hyperpolarization (By similarity). Thought to regulate neuronal excitability by contributing to the slow component of synaptic afterhyperpolarization (By similarity).CATALYTIC ACTIVITY K(+)(in) = K(+)(out)ACTIVITY REGULATION Inhibited by bee venom neurotoxin apamin (PubMed:17142458, PubMed:9287325). Inhibited by d-tubocurarine and tetraethylammonium (TEA) (PubMed:17142458, PubMed:9287325).SUBUNIT Homodimer (PubMed:20689065). Heteromultimer with KCNN2 and KCNN3 (PubMed:20689065, PubMed:9287325). The complex is composed of 4 channel subunits each of which binds to a calmodulin subunit which regulates the channel activity through calcium-binding (By similarity). Interacts with calmodulin (By similarity).SUBCELLULAR LOCATION The coiled-coil domaim mediates heteromeic assembly.SIMILARITY Belongs to the potassium channel KCNN family. KCa2.1/KCNN1 subfamily. |
| description | recommendedName: fullName evidence="13"Small conductance calcium-activated potassium channel protein 1 shortName evidence="10"SK1 shortName: SKCa 1 shortName: SKCa1 shortName evidence="11"hSK1 alternativeName: KCa2.1 |
| geneName | KCNN1 SK |
| identifier | Q92952 |
| isSequenceChanged | FALSE |
| keyword | Alternative splicing Calmodulin-binding Cytoplasm Ion channel Ion transport Membrane Proteomics identification Reference proteome Transmembrane Transmembrane helix Transport |
| modified | [InstanceEdit:9836292] Weiser, Joel, 2023-05-25 [InstanceEdit:9852000] Weiser, Joel, 2023-11-03 [InstanceEdit:9917590] Weiser, Joel, 2024-08-09 [InstanceEdit:9926675] Weiser, Joel, 2024-11-03 |
| name | KCNN1 |
| referenceDatabase | [ReferenceDatabase:2] UniProt |
| referenceGene | [ReferenceDNASequence:8991343] ENSEMBL:ENSG00000105642 KCNN1 [Homo sapiens] |
| secondaryIdentifier | KCNN1_HUMAN Q5KR10 Q6DJU4 |
| sequenceLength | 543 |
| species | [Species:48887] Homo sapiens |
| (isoformParent) | [ReferenceIsoform:234218] UniProt:Q92952-2 KCNN1 [Homo sapiens] [ReferenceIsoform:412523] UniProt:Q92952-1 KCNN1 [Homo sapiens] |
| (referenceEntity) | [EntityWithAccessionedSequence:977494] KCNN1 [plasma membrane] [Homo sapiens] |
| [Change default viewing format] | |
No pathways have been reviewed or authored by UniProt:Q92952 KCNN1 (57937)
