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Details on Person UniProt:P48729 CSNK1A1
| Class:Id | ReferenceGeneProduct:57867 |
|---|---|
| _chainChangeLog | initiator methionine:1 added on Sat February 7 2015;chain:2-337 added on Sat February 7 2015;initiator methionine:1 for 57867 removed on Fri Nov 03 2023;initiator methionine: for 57867 added on Fri Nov 03 2023;initiator methionine: for 57867 removed on Fri Aug 15 2025;initiator methionine:1 for 57867 added on Fri Aug 15 2025 |
| _displayName | UniProt:P48729 CSNK1A1 |
| _timestamp | 2025-08-15 21:53:44 |
| chain | initiator methionine:1 chain:2-337 |
| checksum | 1B2085AE33CAFAC2 |
| comment | FUNCTION Casein kinases are operationally defined by their preferential utilization of acidic proteins such as caseins as substrates (PubMed:11955436, PubMed:1409656, PubMed:18305108, PubMed:23902688). It can phosphorylate a large number of proteins (PubMed:11955436, PubMed:1409656, PubMed:18305108, PubMed:23902688). Participates in Wnt signaling (PubMed:11955436). Phosphorylates CTNNB1 at 'Ser-45' (PubMed:11955436). May phosphorylate PER1 and PER2 (By similarity). May play a role in segregating chromosomes during mitosis (PubMed:1409656). May play a role in keratin cytoskeleton disassembly and thereby, it may regulate epithelial cell migration (PubMed:23902688). Acts as a positive regulator of mTORC1 and mTORC2 signaling in response to nutrients by mediating phosphorylation of DEPTOR inhibitor (PubMed:22017875, PubMed:22017877). Acts as an inhibitor of NLRP3 inflammasome assembly by mediating phosphorylation of NLRP3 (By similarity).CATALYTIC ACTIVITY L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+)CATALYTIC ACTIVITY L-threonyl-[protein] + ATP = O-phospho-L-threonyl-[protein] + ADP + H(+)SUBUNIT Interacts with the Axin complex (PubMed:11955436). Interacts with TUT1, leading to TUT1 phosphorylation (PubMed:1409656). Interacts with FAM83A, FAM83B, FAM83C, FAM83D, FAM83E, FAM83F, FAM83G and FAM83H (via DUF1669) (PubMed:29789297, PubMed:31338967). Interaction with FAM83H recruits CSNK1A1 to keratin filaments (PubMed:23902688).INTERACTION Localizes to the centrosome in interphase cells, and to kinetochore fibers during mitosis. Also recruited to the keratin cytoskeleton (PubMed:23902688).ALTERNATIVE PRODUCTS Phosphorylated by MTOR in response to mitogenic stimulation, leading to its activation.SIMILARITY Belongs to the protein kinase superfamily. CK1 Ser/Thr protein kinase family. Casein kinase I subfamily. |
| description | recommendedName: Casein kinase I isoform alpha shortName: CKI-alpha ecNumber evidence="5"2.7.11.1 alternativeName: CK1 |
| geneName | CSNK1A1 |
| identifier | P48729 |
| isSequenceChanged | FALSE |
| keyword | 3D-structure Acetylation Alternative splicing ATP-binding Cell cycle Cell division Cell projection Centromere Chromosome Cytoplasm Cytoskeleton Direct protein sequencing Kinase Kinetochore Mitosis Nucleotide-binding Nucleus Phosphoprotein Proteomics identification Reference proteome Serine/threonine-protein kinase Transferase Wnt signaling pathway |
| modified | [InstanceEdit:9836292] Weiser, Joel, 2023-05-25 [InstanceEdit:9852000] Weiser, Joel, 2023-11-03 [InstanceEdit:9862192] Weiser, Joel, 2024-02-26 [InstanceEdit:9917590] Weiser, Joel, 2024-08-09 [InstanceEdit:9926675] Weiser, Joel, 2024-11-03 [InstanceEdit:9939033] Weiser, Joel, 2025-02-21 [InstanceEdit:9963647] Weiser, Joel, 2025-08-15 |
| name | CSNK1A1 |
| referenceDatabase | [ReferenceDatabase:2] UniProt |
| referenceGene | [ReferenceDNASequence:8990785] ENSEMBL:ENSG00000113712 CSNK1A1 [Homo sapiens] |
| secondaryIdentifier | KC1A_HUMAN D3DQG0 D3DQG1 Q4JJA0 Q5U046 Q5U047 Q6FGA2 Q71TU5 Q96HD2 Q9UDK3 |
| sequenceLength | 337 |
| species | [Species:48887] Homo sapiens |
| (isoformParent) | [ReferenceIsoform:385411] UniProt:P48729-2 CSNK1A1 [Homo sapiens] [ReferenceIsoform:404152] UniProt:P48729-1 CSNK1A1 [Homo sapiens] [ReferenceIsoform:8970571] UniProt:P48729-3 CSNK1A1 [Homo sapiens] |
| (referenceEntity) | [EntityWithAccessionedSequence:195263] CSNK1A1 [cytosol] [Homo sapiens] [EntityWithAccessionedSequence:5632507] CSNK1A1 [cilium] [Homo sapiens] [EntityWithAccessionedSequence:9943726] CSNK1A1 [nucleoplasm] [Homo sapiens] |
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No pathways have been reviewed or authored by UniProt:P48729 CSNK1A1 (57867)
