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Details on Person UniProt:P03952 KLKB1

Class:Id	ReferenceGeneProduct:57835
_chainChangeLog	signal peptide:1-19 added on Sat February 7 2015;chain:20-390 added on Sat February 7 2015;chain:391-638 added on Sat February 7 2015
_displayName	UniProt:P03952 KLKB1
_timestamp	2024-11-03 19:37:14
chain	signal peptide:1-19 chain:20-390 chain:391-638
checksum	7756B8821AA71DF9
comment	FUNCTION Participates in the surface-dependent activation of blood coagulation. Activates, in a reciprocal reaction, coagulation factor XII/F12 after binding to negatively charged surfaces. Releases bradykinin from HMW kininogen and may also play a role in the renin-angiotensin system by converting prorenin into renin.CATALYTIC ACTIVITY Cleaves selectively Arg-\|-Xaa and Lys-\|-Xaa bonds, including Lys-\|-Arg and Arg-\|-Ser bonds in (human) kininogen to release bradykinin.ACTIVITY REGULATION Inhibited by SERPINA5.SUBUNIT Forms a heterodimer with SERPINA5. The zymogen is activated by factor XIIa, which cleaves the molecule into a light chain, which contains the active site, and a heavy chain, which associates with HMW kininogen. These chains are linked by one or more disulfide bonds. Interacts with iripin-3, a serine protease inhibitor from Ixodes ricinus saliva (PubMed:33732248). Interacts with iripin-1, a serine protease inhibitor from Ixodes ricinus saliva (PubMed:36756125).INTERACTION Found in plasma (at protein level).DISEASE The disease is caused by variants affecting the gene represented in this entry.SIMILARITY Belongs to the peptidase S1 family. Plasma kallikrein subfamily.
description	recommendedName: Plasma kallikrein ecNumber: 3.4.21.34 alternativeName: Fletcher factor alternativeName: Kininogenin alternativeName: Plasma prekallikrein shortName: PKK component recommendedName: Plasma kallikrein heavy chain /component component recommendedName: Plasma kallikrein light chain /component
geneName	KLKB1 KLK3
identifier	P03952
isSequenceChanged	FALSE
keyword	3D-structure Blood coagulation Direct protein sequencing Disease variant Disulfide bond Fibrinolysis Glycoprotein Hemostasis Hydrolase Inflammatory response Protease Proteomics identification Reference proteome Repeat Secreted Serine protease Signal Zymogen
modified	[InstanceEdit:9836292] Weiser, Joel, 2023-05-25 [InstanceEdit:9852000] Weiser, Joel, 2023-11-03 [InstanceEdit:9862192] Weiser, Joel, 2024-02-26 [InstanceEdit:9909836] Weiser, Joel, 2024-05-14 [InstanceEdit:9917590] Weiser, Joel, 2024-08-09 [InstanceEdit:9926675] Weiser, Joel, 2024-11-03
name	KLKB1
referenceDatabase	[ReferenceDatabase:2] UniProt
referenceGene	[ReferenceDNASequence:8994301] ENSEMBL:ENSG00000164344 KLKB1 [Homo sapiens]
secondaryIdentifier	KLKB1_HUMAN A6NH96 B2R8H9 Q17RE8 Q17RE9 Q4W5C3
sequenceLength	638
species	[Species:48887] Homo sapiens
(referenceEntity)	[EntityWithAccessionedSequence:158181] KLKB1(391-638) [extracellular region] [Homo sapiens] [EntityWithAccessionedSequence:158213] KLKB1(20-390) [plasma membrane] [Homo sapiens] [EntityWithAccessionedSequence:158239] KLKB1(20-390) [extracellular region] [Homo sapiens] [EntityWithAccessionedSequence:158277] KLKB1(391-638) [plasma membrane] [Homo sapiens] [EntityWithAccessionedSequence:158385] KLKB1(20-638) [plasma membrane] [Homo sapiens] [EntityWithAccessionedSequence:9857965] KLKB1(20-638) [extracellular region] [Homo sapiens]
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No pathways have been reviewed or authored by UniProt:P03952 KLKB1 (57835)