Query author contributions in Reactome
Reactome depends on collaboration between our curation team and outside experts to assemble and peer-review its pathway modules. The integration of ORCID within Reactome enables us to meet a key challenge with authoring, curating and reviewing biological information by incentivizing and crediting the external experts that contribute their expertise and time to the Reactome curation process. More information is available at ORCID and Reactome.
If you have an ORCID ID that is not listed on this page, please forward this information to us and we will update your Reactome pathway records.
Details on Person UniProt:Q9UK32 RPS6KA6
| Class:Id | ReferenceGeneProduct:57801 |
|---|---|
| _chainChangeLog | chain:1-745 added on Fri February 6 2015 |
| _displayName | UniProt:Q9UK32 RPS6KA6 |
| _timestamp | 2025-02-21 20:00:29 |
| chain | chain:1-745 |
| checksum | 5EC5AB2FA1C19DE8 |
| comment | FUNCTION Constitutively active serine/threonine-protein kinase that exhibits growth-factor-independent kinase activity and that may participate in p53/TP53-dependent cell growth arrest signaling and play an inhibitory role during embryogenesis.CATALYTIC ACTIVITY L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+)CATALYTIC ACTIVITY L-threonyl-[protein] + ATP = O-phospho-L-threonyl-[protein] + ADP + H(+)COFACTOR Constitutively activated by phosphorylation at Ser-232, Ser-372, and Ser-389 in serum-starved cells. Does not require growth factor stimulation for significant kinase activity.SUBUNIT Forms a complex with MAPK3/ERK1 but not with MAPK9 or MAPK14 in serum-starved cells.INTERACTION Predominantly cytosolic.ALTERNATIVE PRODUCTS Phosphorylated at Ser-232, Ser-372, and Ser-389 in serum-starved cells.SIMILARITY Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. S6 kinase subfamily. |
| description | recommendedName: Ribosomal protein S6 kinase alpha-6 shortName: S6K-alpha-6 ecNumber: 2.7.11.1 alternativeName: 90 kDa ribosomal protein S6 kinase 6 shortName: p90-RSK 6 shortName: p90RSK6 alternativeName: Ribosomal S6 kinase 4 shortName: RSK-4 alternativeName: pp90RSK4 |
| geneName | RPS6KA6 RSK4 |
| identifier | Q9UK32 |
| isSequenceChanged | FALSE |
| keyword | 3D-structure Alternative splicing ATP-binding Cytoplasm Kinase Magnesium Metal-binding Nucleotide-binding Nucleus Phosphoprotein Proteomics identification Reference proteome Repeat Serine/threonine-protein kinase Transferase |
| modified | [InstanceEdit:9836292] Weiser, Joel, 2023-05-25 [InstanceEdit:9852000] Weiser, Joel, 2023-11-03 [InstanceEdit:9926675] Weiser, Joel, 2024-11-03 [InstanceEdit:9939033] Weiser, Joel, 2025-02-21 |
| name | RPS6KA6 |
| referenceDatabase | [ReferenceDatabase:2] UniProt |
| referenceGene | [ReferenceDNASequence:8991362] ENSEMBL:ENSG00000072133 RPS6KA6 [Homo sapiens] |
| secondaryIdentifier | KS6A6_HUMAN B2R854 B7ZL90 Q6FHX2 Q8WX28 Q9H4S6 |
| sequenceLength | 745 |
| species | [Species:48887] Homo sapiens |
| (isoformParent) | [ReferenceIsoform:8969725] UniProt:Q9UK32-1 RPS6KA6 [Homo sapiens] [ReferenceIsoform:8969726] UniProt:Q9UK32-2 RPS6KA6 [Homo sapiens] |
| (referenceEntity) | [EntityWithAccessionedSequence:444264] p-S372,S389,T581-RPS6KA6 [nucleoplasm] [Homo sapiens] [EntityWithAccessionedSequence:444266] RPS6KA6 [cytosol] [Homo sapiens] [EntityWithAccessionedSequence:444293] p-S232,T368,S372,S389,T581,S742-RPS6KA6 [nucleoplasm] [Homo sapiens] [EntityWithAccessionedSequence:444381] p-4S,T359,T573-RPS6KA6 [nucleoplasm] [Homo sapiens] [EntityWithAccessionedSequence:444385] RPS6KA6 [nucleoplasm] [Homo sapiens] [EntityWithAccessionedSequence:445402] p-S372,S389,T581-RPS6KA6 [cytosol] [Homo sapiens] [EntityWithAccessionedSequence:9619870] p-S232,T368,S372,S389,T581,S742-RPS6KA6 [cytosol] [Homo sapiens] [EntityWithAccessionedSequence:9619958] p-T368,S372,T581-RPS6KA6 [cytosol] [Homo sapiens] [EntityWithAccessionedSequence:9619985] p-T368,S372,S389,T581,S742-RPS6KA6 [cytosol] [Homo sapiens] |
| (referenceSequence) | [ModifiedResidue:444249] O-phospho-L-serine at 372 [ModifiedResidue:444254] O-phospho-L-serine at 389 [ModifiedResidue:444255] O-phospho-L-threonine at 581 [ModifiedResidue:444296] O-phospho-L-serine at 232 [ModifiedResidue:444380] O-phospho-L-serine at 732 [ModifiedResidue:444382] O-phospho-L-threonine at 359 [ModifiedResidue:9619974] O-phospho-L-threonine at 368 [ModifiedResidue:9619992] O-phospho-L-serine at 742 |
| [Change default viewing format] | |
No pathways have been reviewed or authored by UniProt:Q9UK32 RPS6KA6 (57801)
