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Details on Person UniProt:P04264 KRT1
| Class:Id | ReferenceGeneProduct:57741 |
|---|---|
| _chainChangeLog | initiator methionine:1 added on Fri February 6 2015;chain:2-644 added on Fri February 6 2015;initiator methionine:1 for 57741 removed on Fri Nov 03 2023;initiator methionine: for 57741 added on Fri Nov 03 2023;initiator methionine: for 57741 removed on Fri Aug 15 2025;initiator methionine:1 for 57741 added on Fri Aug 15 2025 |
| _displayName | UniProt:P04264 KRT1 |
| _timestamp | 2025-08-15 22:01:16 |
| chain | initiator methionine:1 chain:2-644 |
| checksum | CE5DDE97388F5017 |
| comment | FUNCTION May regulate the activity of kinases such as PKC and SRC via binding to integrin beta-1 (ITB1) and the receptor of activated protein C kinase 1 (RACK1). In complex with C1QBP is a high affinity receptor for kininogen-1/HMWK.SUBUNIT Heterotetramer of two type I and two type II keratins (PubMed:24940650, PubMed:27595935). Heterodimer with KRT10 (PubMed:24940650, PubMed:27595935). Two heterodimers of KRT1 and KRT10 form a heterotetramer (PubMed:27595935). Forms a heterodimer with KRT14; the interaction is more abundant in the absence of KRT5 (By similarity). Interacts with PLEC isoform 1C, when in a heterodimer with KRT10 (PubMed:24940650). Interacts with ITGB1 in the presence of RACK1 and SRC, and with RACK1 (PubMed:17956333). Interacts with C1QBP; the association represents a cell surface kininogen receptor (PubMed:21544310). Interacts with EPPK1; interaction is dependent of higher-order structure of intermediate filament (PubMed:16923132).INTERACTION The source of this protein is neonatal foreskin. The 67-kDa type II keratins are expressed in terminally differentiating epidermis.INDUCTION Repressed in keratinocytes by all-trans retinoic acid (ATRA), via reduction of mRNA stability.PTM Undergoes deimination of some arginine residues (citrullination).POLYMORPHISM There are two size variants of KRT1, termed allele 1A and allele 1B with allelic frequencies of 0.61 and 0.39. Allele 1B lacks 7 residues compared to allele 1A.DISEASE The disease is caused by variants affecting the gene represented in this entry.DISEASE The disease is caused by variants affecting the gene represented in this entry.DISEASE The disease is caused by variants affecting the gene represented in this entry.DISEASE The disease is caused by variants affecting the gene represented in this entry.DISEASE The disease is caused by variants affecting the gene represented in this entry.DISEASE The disease is caused by variants affecting the gene represented in this entry.MISCELLANEOUS There are two types of cytoskeletal and microfibrillar keratin: I (acidic; 40-55 kDa) and II (neutral to basic; 56-70 kDa).SIMILARITY Belongs to the intermediate filament family.CAUTION A peptide corresponding to residues 278 to 289 was isolated as part of plant proteomics studies and was originally thought to be of plant origin (PubMed:16529377, PubMed:18602030, PubMed:19412582). However, it was later shown that it is likely to be human type II keratin, a common contaminant in proteomic analyzes (PubMed:23895828).ONLINE INFORMATION Keratin-1 entry |
| description | recommendedName: Keratin, type II cytoskeletal 1 alternativeName: 67 kDa cytokeratin alternativeName: Cytokeratin-1 shortName: CK-1 alternativeName: Hair alpha protein alternativeName: Keratin-1 shortName: K1 alternativeName: Type-II keratin Kb1 |
| geneName | KRT1 KRTA |
| identifier | P04264 |
| isSequenceChanged | FALSE |
| keyword | 3D-structure Cell membrane Citrullination Coiled coil Cytoplasm Direct protein sequencing Disease variant Ichthyosis Intermediate filament Keratin Membrane Methylation Palmoplantar keratoderma Phosphoprotein Proteomics identification Reference proteome |
| modified | [InstanceEdit:9836292] Weiser, Joel, 2023-05-25 [InstanceEdit:9852000] Weiser, Joel, 2023-11-03 [InstanceEdit:9909836] Weiser, Joel, 2024-05-14 [InstanceEdit:9917590] Weiser, Joel, 2024-08-09 [InstanceEdit:9926675] Weiser, Joel, 2024-11-03 [InstanceEdit:9963647] Weiser, Joel, 2025-08-15 |
| name | KRT1 |
| referenceDatabase | [ReferenceDatabase:2] UniProt |
| referenceGene | [ReferenceDNASequence:8958003] ENSEMBL:ENSG00000167768 KRT1 [Homo sapiens] |
| secondaryIdentifier | K2C1_HUMAN B2RA01 P85925 P86104 Q14720 Q6GSJ0 Q9H298 |
| sequenceLength | 644 |
| species | [Species:48887] Homo sapiens |
| (referenceEntity) | [EntityWithAccessionedSequence:6800428] KRT1 [ficolin-1-rich granule lumen] [Homo sapiens] [EntityWithAccessionedSequence:6800471] KRT1 [extracellular region] [Homo sapiens] [EntityWithAccessionedSequence:6809649] KRT1 [cytosol] [Homo sapiens] [EntityWithAccessionedSequence:9857815] KRT1 [plasma membrane] [Homo sapiens] |
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No pathways have been reviewed or authored by UniProt:P04264 KRT1 (57741)
