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Details on Person UniProt:P05783 KRT18
| Class:Id | ReferenceGeneProduct:57711 |
|---|---|
| _chainChangeLog | initiator methionine:1 added on Sat February 7 2015;chain:2-430 added on Sat February 7 2015;initiator methionine:1 for 57711 removed on Fri Nov 03 2023;initiator methionine: for 57711 added on Fri Nov 03 2023;initiator methionine: for 57711 removed on Fri Aug 15 2025;initiator methionine:1 for 57711 added on Fri Aug 15 2025 |
| _displayName | UniProt:P05783 KRT18 |
| _timestamp | 2026-02-20 23:06:49 |
| chain | initiator methionine:1 chain:2-430 |
| checksum | 1E5604C6BCC7A17A |
| comment | FUNCTION Required for the formation of KRT8/KRT18 filaments that are involved in ARHGEF40-mediated actin stress fiber formation and tensional force-induced stress fiber formation and reinforcement (PubMed:26823019). Also acts downstream of ROCK kinase activation as part of a positive feedback mechanism in response to cellular mechanical stress loading (PubMed:26823019). Organization and orientation of KRT18 filaments are responsible for the properly elongated morphology of epithelial tubules (By similarity). Involved in the uptake of thrombin-antithrombin complexes by hepatic cells (By similarity). When phosphorylated, plays a role in filament reorganization. Involved in the delivery of mutated CFTR to the plasma membrane. Together with KRT8, is involved in interleukin-6 (IL-6)-mediated barrier protection.SUBUNIT Heterotetramer of two type I and two type II keratins. KRT18 associates with KRT8 (PubMed:10852826, PubMed:24940650, PubMed:26823019). Interacts with PLEC isoform 1C, when in a heterodimer with KRT8 (PubMed:24940650). Interacts with the thrombin-antithrombin complex (By similarity). Interacts with PNN and mutated CFTR. Interacts with YWHAE, YWHAH and YWHAZ only when phosphorylated. Interacts with DNAJB6, TCHP and TRADD. Interacts with FAM83H (PubMed:23902688). Interacts with EPPK1 (By similarity). Interacts with PKP1 and PKP2 (PubMed:10852826). KRT8/KRT18 heterodimers interact with ARHGEF40 (via N-terminal, central and C-terminal domains) (PubMed:26823019). The interaction facilitates actin stress fiber formation, force-induced stress fiber reinforcement and organization of KRT8/KRT18 networks (PubMed:30929300).SUBUNIT (Microbial infection) Interacts with hepatitis C virus/HCV core protein.INTERACTION Expressed in colon, placenta, liver and very weakly in exocervix. Increased expression observed in lymph nodes of breast carcinoma.INDUCTION By IL6/interleukin-6.PTM Phosphorylation at Ser-34 increases during mitosis. Hyperphosphorylated at Ser-53 in diseased cirrhosis liver. Phosphorylation increases by IL-6.PTM Proteolytically cleaved by caspases during epithelial cell apoptosis. Cleavage occurs at Asp-238 by either caspase-3, caspase-6 or caspase-7.PTM O-GlcNAcylation increases solubility, and decreases stability by inducing proteasomal degradation.DISEASE The disease is caused by variants affecting the gene represented in this entry.MISCELLANEOUS There are two types of cytoskeletal and microfibrillar keratin: I (acidic; 40-55 kDa) and II (neutral to basic; 56-70 kDa).SIMILARITY Belongs to the intermediate filament family. |
| description | recommendedName: fullName evidence="34"Keratin, type I cytoskeletal 18 alternativeName: Cell proliferation-inducing gene 46 protein alternativeName: fullName evidence="33"Cytokeratin-18 shortName evidence="33"CK-18 alternativeName: fullName evidence="35"Keratin-18 shortName: K18 |
| geneName | KRT18 CYK18 PIG46 |
| identifier | P05783 |
| isSequenceChanged | FALSE |
| keyword | Acetylation Cell cycle Coiled coil Cytoplasm Direct protein sequencing Disease variant Glycoprotein Host-virus interaction Intermediate filament Isopeptide bond Keratin Methylation Nucleus Phosphoprotein Proteomics identification Reference proteome Ubl conjugation |
| modified | [InstanceEdit:9836292] Weiser, Joel, 2023-05-25 [InstanceEdit:9852000] Weiser, Joel, 2023-11-03 [InstanceEdit:9926675] Weiser, Joel, 2024-11-03 [InstanceEdit:9963647] Weiser, Joel, 2025-08-15 [InstanceEdit:9983091] Weiser, Joel, 2026-02-20 |
| name | KRT18 |
| referenceDatabase | [ReferenceDatabase:2] UniProt |
| referenceGene | [ReferenceDNASequence:8996657] ENSEMBL:ENSG00000111057 KRT18 [Homo sapiens] |
| secondaryIdentifier | K1C18_HUMAN Q53G38 Q5U0N8 Q9BW26 |
| sequenceLength | 430 |
| species | [Species:48887] Homo sapiens |
| (referenceEntity) | [EntityWithAccessionedSequence:201582] KRT18 [cytosol] [Homo sapiens] |
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No pathways have been reviewed or authored by UniProt:P05783 KRT18 (57711)
