Query author contributions in Reactome
Reactome depends on collaboration between our curation team and outside experts to assemble and peer-review its pathway modules. The integration of ORCID within Reactome enables us to meet a key challenge with authoring, curating and reviewing biological information by incentivizing and crediting the external experts that contribute their expertise and time to the Reactome curation process. More information is available at ORCID and Reactome.
If you have an ORCID ID that is not listed on this page, please forward this information to us and we will update your Reactome pathway records.
Details on Person UniProt:Q04695 KRT17
| Class:Id | ReferenceGeneProduct:57709 |
|---|---|
| _chainChangeLog | chain:1-432 added on Sat February 7 2015 |
| _displayName | UniProt:Q04695 KRT17 |
| _timestamp | 2026-02-20 21:40:42 |
| chain | chain:1-432 |
| checksum | 35B429243F47EB5C |
| comment | FUNCTION Type I keratin involved in the formation and maintenance of various skin appendages, specifically in determining shape and orientation of hair (By similarity). Required for the correct growth of hair follicles, in particular for the persistence of the anagen (growth) state (By similarity). Modulates the function of TNF in the specific context of hair cycling. Regulates protein synthesis and epithelial cell growth through binding to the adapter protein SFN and by stimulating Akt/mTOR pathway (By similarity). Involved in tissue repair. May be a marker of basal cell differentiation in complex epithelia and therefore indicative of a certain type of epithelial 'stem cells'. Acts as a promoter of epithelial proliferation by acting a regulator of immune response in skin: promotes Th1/Th17-dominated immune environment contributing to the development of basaloid skin tumors (By similarity). May act as an autoantigen in the immunopathogenesis of psoriasis, with certain peptide regions being a major target for autoreactive T-cells and hence causing their proliferation.SUBUNIT Heterodimer of a type I and a type II keratin. KRT17 associates with KRT6 isomers (KRT6A or KRT6B). Interacts with TRADD and SFN (By similarity).INTERACTION Expressed in the outer root sheath and medulla region of hair follicle specifically from eyebrow and beard, digital pulp, nail matrix and nail bed epithelium, mucosal stratified squamous epithelia and in basal cells of oral epithelium, palmoplantar epidermis and sweat and mammary glands. Also expressed in myoepithelium of prostate, basal layer of urinary bladder, cambial cells of sebaceous gland and in exocervix (at protein level).INDUCTION Induced in damaged or stressed epidermis. Induced by the cytokines interferon-gamma (IFN-gamma), tumor necrosis factor alpha (TNF) and transforming growth factor-alpha (TGF-alpha), and by the potent NF-kappa B inhibitor compounds Bay 11-7082 and Bay 11-7085. Down-regulated by the drug Imatinib.PTM Phosphorylation at Ser-44 occurs in a growth- and stress-dependent fashion in skin keratinocytes, it has no effect on filament organization.DISEASE The disease is caused by variants affecting the gene represented in this entry.DISEASE The disease is caused by variants affecting the gene represented in this entry.DISEASE KRT16 and KRT17 are coexpressed only in pathological situations such as metaplasias and carcinomas of the uterine cervix and in psoriasis vulgaris.DISEASE Defects in KRT17 may be the cause of a keratinization disorder with associated thrombocytopenia characterized by generalized harlequin ichthyosis that progress into palmoplantar keratoderma.MISCELLANEOUS There are two types of cytoskeletal and microfibrillar keratin: I (acidic; 40-55 kDa) and II (neutral to basic; 56-70 kDa).SIMILARITY Belongs to the intermediate filament family.SEQUENCE CAUTION Keratin-17 entry |
| description | recommendedName: Keratin, type I cytoskeletal 17 alternativeName: 39.1 alternativeName: Cytokeratin-17 shortName: CK-17 alternativeName: Keratin-17 shortName: K17 |
| geneName | KRT17 |
| identifier | Q04695 |
| isSequenceChanged | FALSE |
| keyword | Coiled coil Cytoplasm Disease variant Ectodermal dysplasia Intermediate filament Isopeptide bond Keratin Palmoplantar keratoderma Phosphoprotein Proteomics identification Reference proteome Ubl conjugation |
| modified | [InstanceEdit:9836292] Weiser, Joel, 2023-05-25 [InstanceEdit:9852000] Weiser, Joel, 2023-11-03 [InstanceEdit:9917590] Weiser, Joel, 2024-08-09 [InstanceEdit:9926675] Weiser, Joel, 2024-11-03 [InstanceEdit:9983091] Weiser, Joel, 2026-02-20 |
| name | KRT17 |
| referenceDatabase | [ReferenceDatabase:2] UniProt |
| referenceGene | [ReferenceDNASequence:8997220] ENSEMBL:ENSG00000128422 KRT17 [Homo sapiens] |
| secondaryIdentifier | K1C17_HUMAN A5Z1M9 A5Z1N0 A5Z1N1 A5Z1N2 A6NDV6 A6NKQ2 Q6IP98 Q8N1P6 |
| sequenceLength | 432 |
| species | [Species:48887] Homo sapiens |
| (referenceEntity) | [EntityWithAccessionedSequence:201583] KRT17 [cytosol] [Homo sapiens] |
| [Change default viewing format] | |
No pathways have been reviewed or authored by UniProt:Q04695 KRT17 (57709)
