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Details on Person UniProt:P08779 KRT16
| Class:Id | ReferenceGeneProduct:57707 |
|---|---|
| _chainChangeLog | chain:1-473 added on Fri February 6 2015 |
| _displayName | UniProt:P08779 KRT16 |
| _timestamp | 2024-11-03 19:41:29 |
| chain | chain:1-473 |
| checksum | BA8CE9F4716A88A4 |
| comment | FUNCTION Epidermis-specific type I keratin that plays a key role in skin. Acts as a regulator of innate immunity in response to skin barrier breach: required for some inflammatory checkpoint for the skin barrier maintenance.SUBUNIT Heterodimer of a type I and a type II keratin. KRT16 associates with KRT6 isomers (KRT6A or KRT6B) (By similarity). Interacts with TCHP (PubMed:15731013). Interacts with TRADD (By similarity).INTERACTION Expressed in the corneal epithelium (at protein level).MASS SPECTROMETRY The disease is caused by variants affecting the gene represented in this entry.DISEASE The disease is caused by variants affecting the gene represented in this entry.DISEASE KRT16 and KRT17 are coexpressed only in pathological situations such as metaplasias and carcinomas of the uterine cervix and in psoriasis vulgaris.MISCELLANEOUS There are two types of cytoskeletal and microfibrillar keratin, I (acidic) and II (neutral to basic) (40-55 and 56-70 kDa, respectively).SIMILARITY Belongs to the intermediate filament family. |
| description | recommendedName: Keratin, type I cytoskeletal 16 alternativeName: Cytokeratin-16 shortName: CK-16 alternativeName: Keratin-16 shortName: K16 |
| geneName | KRT16 KRT16A |
| identifier | P08779 |
| isSequenceChanged | FALSE |
| keyword | Coiled coil Direct protein sequencing Disease variant Ectodermal dysplasia Intermediate filament Keratin Palmoplantar keratoderma Proteomics identification Reference proteome |
| modified | [InstanceEdit:9836292] Weiser, Joel, 2023-05-25 [InstanceEdit:9852000] Weiser, Joel, 2023-11-03 [InstanceEdit:9926675] Weiser, Joel, 2024-11-03 |
| name | KRT16 |
| referenceDatabase | [ReferenceDatabase:2] UniProt |
| referenceGene | [ReferenceDNASequence:8997769] ENSEMBL:ENSG00000186832 KRT16 [Homo sapiens] |
| secondaryIdentifier | K1C16_HUMAN A8K488 P30654 Q16402 Q9UBG8 |
| sequenceLength | 473 |
| species | [Species:48887] Homo sapiens |
| (referenceEntity) | [EntityWithAccessionedSequence:201581] KRT16 [cytosol] [Homo sapiens] |
| [Change default viewing format] | |
No pathways have been reviewed or authored by UniProt:P08779 KRT16 (57707)
