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Details on Person UniProt:P02533 KRT14
| Class:Id | ReferenceGeneProduct:57703 |
|---|---|
| _chainChangeLog | chain:1-472 added on Fri February 6 2015 |
| _displayName | UniProt:P02533 KRT14 |
| _timestamp | 2024-11-03 20:19:38 |
| chain | chain:1-472 |
| checksum | 120BA30BA2F8E397 |
| comment | FUNCTION The nonhelical tail domain is involved in promoting KRT5-KRT14 filaments to self-organize into large bundles and enhances the mechanical properties involved in resilience of keratin intermediate filaments in vitro.SUBUNIT Heterotetramer of two type I and two type II keratins (By similarity). Forms a disulfide-linked heterodimer (via 2B domains) with KRT5 (via 2B domains) (PubMed:22705788, PubMed:24940650). Forms a heterodimer with KRT1; the interaction is more abundant in the absence of KRT5 (By similarity). Interacts with PLEC isoform 1C, when in a heterodimer with KRT5 (PubMed:24940650). Interacts with TRADD and with keratin filaments (PubMed:11684708). Associates with other type I keratins (PubMed:11724817). Interacts with EPPK1 (By similarity). Interacts with KLHL24 (PubMed:27798626). Interacts with PKP1 (via N-terminus) and PKP2 (PubMed:10852826).INTERACTION Expressed in both as a filamentous pattern.TISSUE SPECIFICITY Expressed in the corneal epithelium (at protein level) (PubMed:26758872). Detected in the basal layer, lowered within the more apically located layers specifically in the stratum spinosum, stratum granulosum but is not detected in stratum corneum. Strongly expressed in the outer root sheath of anagen follicles but not in the germinative matrix, inner root sheath or hair (PubMed:9457912). Found in keratinocytes surrounding the club hair during telogen (PubMed:9457912).PTM A disulfide bond is formed between rather than within filaments and promotes the formation of a keratin filament cage around the nucleus.PTM Ubiquitinated by the BCR(KLHL24) E3 ubiquitin ligase complex.DISEASE The disease is caused by variants affecting the gene represented in this entry.DISEASE The disease is caused by variants affecting the gene represented in this entry.DISEASE The disease is caused by variants affecting the gene represented in this entry.DISEASE The disease is caused by variants affecting the gene represented in this entry.DISEASE The disease is caused by variants affecting the gene represented in this entry.DISEASE The disease is caused by variants affecting the gene represented in this entry.MISCELLANEOUS There are two types of cytoskeletal and microfibrillar keratin: I (acidic; 40-55 kDa) and II (neutral to basic; 56-70 kDa).SIMILARITY Belongs to the intermediate filament family. |
| description | recommendedName: Keratin, type I cytoskeletal 14 alternativeName: Cytokeratin-14 shortName: CK-14 alternativeName: Keratin-14 shortName: K14 |
| geneName | KRT14 |
| identifier | P02533 |
| isSequenceChanged | FALSE |
| keyword | 3D-structure Coiled coil Cytoplasm Disease variant Disulfide bond Ectodermal dysplasia Epidermolysis bullosa Intermediate filament Keratin Nucleus Palmoplantar keratoderma Phosphoprotein Proteomics identification Reference proteome Ubl conjugation |
| modified | [InstanceEdit:9836292] Weiser, Joel, 2023-05-25 [InstanceEdit:9852000] Weiser, Joel, 2023-11-03 [InstanceEdit:9917590] Weiser, Joel, 2024-08-09 [InstanceEdit:9926675] Weiser, Joel, 2024-11-03 |
| name | KRT14 |
| referenceDatabase | [ReferenceDatabase:2] UniProt |
| referenceGene | [ReferenceDNASequence:8993695] ENSEMBL:ENSG00000186847 KRT14 [Homo sapiens] |
| secondaryIdentifier | K1C14_HUMAN Q14715 Q53XY3 Q9BUE3 Q9UBN2 Q9UBN3 Q9UCY4 |
| sequenceLength | 472 |
| species | [Species:48887] Homo sapiens |
| (referenceEntity) | [EntityWithAccessionedSequence:446091] KRT14 [cytosol] [Homo sapiens] |
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No pathways have been reviewed or authored by UniProt:P02533 KRT14 (57703)
