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Details on Person UniProt:Q99456 KRT12
Class:Id
ReferenceGeneProduct:57699
_chainChangeLog
chain:1-494 added on Fri February 6 2015
_displayName
UniProt:Q99456 KRT12
_timestamp
2024-11-03 20:19:38
chain
chain:1-494
checksum
75C981380532B682
comment
FUNCTION Involved in corneal epithelium organization, integrity and corneal keratin expression.SUBUNIT Heterotetramer of two type I and two type II keratins. Keratin-3 associates with keratin-12.TISSUE SPECIFICITY Expressed in the corneal epithelium (at protein level).DISEASE The disease is caused by variants affecting the gene represented in this entry.MISCELLANEOUS There are two types of cytoskeletal and microfibrillar keratin: I (acidic; 40-55 kDa) and II (neutral to basic; 56-70 kDa).SIMILARITY Belongs to the intermediate filament family.ONLINE INFORMATION Keratin-12 entry
description
recommendedName: Keratin, type I cytoskeletal 12 alternativeName: Cytokeratin-12 shortName: CK-12 alternativeName: Keratin-12 shortName: K12
geneName
KRT12
identifier
Q99456
isSequenceChanged
FALSE
keyword
Coiled coil Corneal dystrophy Direct protein sequencing Disease variant Intermediate filament Keratin Proteomics identification Reference proteome
